Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Serhan Unlu"'
Autor:
Jaymeson Gordon, Carlos Bravo-Perez, Luca Guarnera, Serhan Unlu, Naomi Kawashima, Arooj Ahmed, Christopher Haddad, Yasuo Kubota, Ishani Nautiyal, Fauzia Ullah, Danai Dima, Nakisha D. Williams, Tariq Kewan, Waled Bahaj, Hetty E. Carraway, Chao-Yie Yang, Carmelo Gurnari, Valeria Visconte, Jaroslaw P. Maciejewski
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/5ac3055fb4da4ce3afb8ec78e891a1df
Autor:
Juan Joseph Young, Hong-Jai Park, Minhyung Kim, Jennefer Par-Young, Hugh Bartlett, Hye Sun Kim, Serhan Unlu, Lais Osmani, Min Sun Shin, Richard Bucala, Christopher H. van Dyck, Heather Allore, Adam P. Mecca, Sungyong You, Insoo Kang
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Background Memory CD8+ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8+ T cells expressing low levels of IL-7 receptor alpha (IL-7Rαlow) and the presence of its gene signature (i.e
Externí odkaz:
https://doaj.org/article/cfa2d915209747c0a4d52c103cb96478
Autor:
Mariam Markouli, Fauzia Ullah, Serhan Unlu, Najiullah Omar, Nerea Lopetegui-Lia, Marissa Duco, Faiz Anwer, Shahzad Raza, Danai Dima
Publikováno v:
Current Oncology, Vol 30, Iss 7, Pp 6330-6352 (2023)
Multiple myeloma is the second-most common hematologic malignancy in adults worldwide. Despite ongoing advancement in therapeutic modalities, it remains an incurable disease with a 5-year survival rate of approximately 50%. The recent development and
Externí odkaz:
https://doaj.org/article/d1e0716ee8924a55b9221dd4d2fcd197
Publikováno v:
International Journal of Cardiology Congenital Heart Disease, Vol 8, Iss , Pp 100359- (2022)
Introduction: T cells developed in the thymus play a key role in vaccine immunity. Thymectomy occurs during infant congenital heart surgery and results in an altered T cell distribution. We investigated if adults with congenital heart disease (ACHD)
Externí odkaz:
https://doaj.org/article/86f64c323e24447ab3baa4b9291ca164
Autor:
Olisaemeka Ogbue, Serhan Unlu, Gogo-Ogute Ibodeng, Abhay Singh, Arda Durmaz, Valeria Visconte, John C. Molina
Publikováno v:
Cancers, Vol 15, Iss 9, p 2477 (2023)
Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) are genetically complex and diverse diseases. Such complexity makes challenging the monitoring of response to treatment. Measurable residual disease (MRD) assessment is a powerful tool f
Externí odkaz:
https://doaj.org/article/0cc0078ec35547f28d21aca974b8353f
Autor:
Serhan Unlu, Joseph W. Kim
Publikováno v:
Current Oncology Reports. 24:1619-1631
We highlight the clinical development of Poly (ADP-Ribose) polymerase (PARP) inhibitors in prostate cancer.Approximately 10 to 30% of metastatic prostate cancer patients carry germline or somatic mutations in DNA repair pathways. BRCA2 is the most co
Autor:
Juan Young, Hong-Jai Park, Minhyung Kim, Jennefer Par-Young, Hugh Bartlett, Hye Sun Kim, Serhan Unlu, Lais Osmani, Min Sun Shin, Richard Bucala, Christopher van Dyck, Heather Allore, Adam Mecca, Sungyong You, Insoo Kang
CD45RA+ effector memory (EM) CD8+ T cell expansion was reported in Alzheimer’s disease (AD). Such cells are IL-7 receptor alpha (IL-7Rα)low EM CD8+ T cells, which expand with age and have a unique aging gene signature (i.e., IL-7Rαlow aging genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::518cb522d36126771d62ccc0e93e612a
https://doi.org/10.21203/rs.3.rs-2736771/v1
https://doi.org/10.21203/rs.3.rs-2736771/v1
Autor:
Joseph W. Kim, Rana R. McKay, Marc R. Radke, Shilin Zhao, Mary-Ellen Taplin, Nancy B. Davis, Paul Monk, Leonard J. Appleman, Primo N. Lara, Ulka N. Vaishampayan, Jingsong Zhang, Asit K. Paul, Glenn Bubley, Eliezer M. Van Allen, Serhan Unlu, Ying Huang, Massimo Loda, Geoffrey I. Shapiro, Peter M. Glazer, Patricia M. LoRusso, S. Percy Ivy, Yu Shyr, Elizabeth M. Swisher, Daniel P. Petrylak
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
PURPOSE Cediranib, a pan-vascular endothelial growth factor receptor inhibitor, suppresses expression of homologous recombination repair (HRR) genes and increases sensitivity to poly-(ADP-ribose) polymerase inhibition in preclinical models. We invest
Autor:
Juan J. Young, Hong-Jai Park, Minhyung Kim, Jennefer Par-Young, Hugh H. Bartlett, Hye Sun Kim, Min Sun Shin, Serhan Unlu, Richard Bucala, Christopher H. Van Dyck, Heather G. Allore, Adam P. Mecca, Sungyong You, Insoo Kang
INTRODUCTIONEffector memory (EM) CD8+ T cells have been associated with poor cognition in Alzheimer’s disease (AD). Our lab recently discovered an age-associated gene expression signature of IL-7 receptor alpha (IL-7Rα)low EM CD8+ T cells. We hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::066b6c3d30ad8eab9acea6933948ef53
https://doi.org/10.1101/2022.09.29.510171
https://doi.org/10.1101/2022.09.29.510171
Autor:
Olisaemeka Ogbue, Serhan Unlu, Sharmeen Sorathia, Abdel Rahman Nanah, Abdo S. Haddad, Hamed Daw
Publikováno v:
Journal of Clinical Oncology. 41:801-801
801 Background: Immune checkpoint inhibitors (ICIs) have several approved indications in the treatment of gastrointestinal (GI) malignancies including metastatic disease. The adverse events related to ICI use or Immune related adverse events (irAEs)