Výsledky vyhledávání - "Sergiy Zalevskyi"

Synthesis and anticonvulsant activity evaluation of n-[(2,4-dichlorophenyl)methyl]-2-(2,4-dioxo-1h-quinazolin-3-yl)acetamide novel 1-benzylsubstituted derivatives

Autor: Wassim El Kayal, Hanna Severina, Vadim Tsyvunin, Sergiy Zalevskyi, Sergiy Shtrygol', Sergiy Vlasov, Olga Golovchenko, Sergiy Kovalenko, Victoriya Georgiyants

Publikováno v: ScienceRise: Pharmaceutical Science. :58-69

The aim. Synthesis of 1-benzylsubstituted derivatives of N-[(2,4-dichlorophenyl)methyl]-2-(2,4-dioxo-1h-quinazolin-3-yl)acetamide, and determination of affinity to GABAergic biotargets with the following anticonvulsant activity estimation using PTZ-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3332868e70fa92ec4200a697c583e3
https://doi.org/10.15587/2519-4852.2022.253554

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Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico

Autor: Sergiy Shtrygol, Sergiy Zalevskyi, Mariia Mishchenko, Diana Shtrygol, Hanna Severina, Wassim El Kayal, Victoriya Georgiyants

Publikováno v: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti. 71(5)

The anticonvulsant spectrum of the original promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide was studied. The compound had a pronounced anticonvulsant effect, significantly reducing the mortality of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed09d46b58224517dd22e0ac1e76256
https://pubmed.ncbi.nlm.nih.gov/36443027

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