Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sergiy Velychko"'
Autor:
Thorsten Schaefer, Nitish Mittal, Hui Wang, Meric Ataman, Silvia Candido, Jonas Lötscher, Sergiy Velychko, Lionel Tintignac, Thomas Bock, Anastasiya Börsch, Jochen Baßler, Tata Nageswara Rao, Jakub Zmajkovic, Sarah Roffeis, Jordan Löliger, Francis Jacob, Alain Dumlin, Christoph Schürch, Alexander Schmidt, Radek C. Skoda, Matthias P. Wymann, Christoph Hess, Hans R. Schöler, Holm Zaehres, Ed Hurt, Mihaela Zavolan, Claudia Lengerke
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114807- (2024)
Summary: Stemness and pluripotency are mediated by transcriptional master regulators that promote self-renewal and repress cell differentiation, among which is the high-mobility group (HMG) box transcription factor SOX2. Dysregulated SOX2 expression,
Externí odkaz:
https://doaj.org/article/3f4435c1df914aa5bdc0b2931130faf7
Autor:
Isabel Rosety, Alise Zagare, Claudia Saraiva, Sarah Nickels, Paul Antony, Catarina Almeida, Enrico Glaab, Rashi Halder, Sergiy Velychko, Thomas Rauen, Hans R. Schöler, Silvia Bolognin, Thomas Sauter, Javier Jarazo, Rejko Krüger, Jens C. Schwamborn
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract The mechanisms underlying Parkinson’s disease (PD) etiology are only partially understood despite intensive research conducted in the field. Recent evidence suggests that early neurodevelopmental defects might play a role in cellular susce
Externí odkaz:
https://doaj.org/article/c8a751fed40447b48458240c44c2fae3
Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells
Autor:
Le Xiong, Erik A Tolen, Jinmi Choi, Sergiy Velychko, Livia Caizzi, Taras Velychko, Kenjiro Adachi, Caitlin M MacCarthy, Michael Lidschreiber, Patrick Cramer, Hans R Schöler
Publikováno v:
eLife, Vol 11 (2022)
The transcription factor Oct4 is essential for the maintenance and induction of stem cell pluripotency, but its functional roles are not fully understood. Here, we investigate the functions of Oct4 by depleting and subsequently recovering it in mouse
Externí odkaz:
https://doaj.org/article/1d5965331e63415ea1891c5a5bf6e818
Autor:
Vikas Malik, Laura V. Glaser, Dennis Zimmer, Sergiy Velychko, Mingxi Weng, Markus Holzner, Marius Arend, Yanpu Chen, Yogesh Srivastava, Veeramohan Veerapandian, Zahir Shah, Miguel A. Esteban, Huating Wang, Jiekai Chen, Hans R. Schöler, Andrew P. Hutchins, Sebastiaan H. Meijsing, Sebastian Pott, Ralf Jauch
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Oct4, along with Sox2 and Klf4 can induce pluripotency, but structurally similar factors like Oct6 cannot. Here, using pluripotency competent and incompetent factors, the authors show that Sox2 plays a dominant role in facilitating chromatin opening
Externí odkaz:
https://doaj.org/article/5d839fd6128d4d118a7cbf72a69b4f17
Autor:
Sergiy Velychko, Kyuree Kang, Sung Min Kim, Tae Hwan Kwak, Kee-Pyo Kim, Chanhyeok Park, Kwonho Hong, ChiHye Chung, Jung Keun Hyun, Caitlin M. MacCarthy, Guangming Wu, Hans R. Schöler, Dong Wook Han
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 30-39.e4 (2019)
Summary: Simultaneous expression of Oct4, Klf4, Sox2, and cMyc induces pluripotency in somatic cells (iPSCs). Replacing Oct4 with the neuro-specific factor Brn4 leads to transdifferentiation of fibroblasts into induced neural stem cells (iNSCs). Howe
Externí odkaz:
https://doaj.org/article/ae90a700c247457aa7cef3a294166ccf
Autor:
Caitlin M. MacCarthy, Vikas Malik, Guangming Wu, Taras Velychko, Gal Keshet, Ralf Jauch, Vlad Cojocaru, Hans R. Schöler, Sergiy Velychko
The discovery of induced pluripotent stem cell (iPSC) technology by Shinya Yamanaka has truly enabled the stem cell field. After 16 years of intense research, the delivery methods and culture media have improved but the original factors—Oct4, Sox2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c34ea177b5561bcfb4addc8cf372d0e0
https://doi.org/10.1101/2022.09.23.509242
https://doi.org/10.1101/2022.09.23.509242
Autor:
Farina Windener, Odile Boespflug-Tanguy, Qiao Ling Cui, Sabah Mozafari, Benjamín Hernández-Rodríguez, Anne Baron-Van Evercooren, Christian Thomas, Tanja Kuhlmann, Hans R. Schöler, Jürgen Winkler, Yu Kang T. Xu, Martin Stehling, Linda Ottoboni, Gianvito Martino, Marc Ehrlich, Stefanie Albrecht, Konstantina Chanoumidou, Sergiy Velychko, Juan M. Vaquerizas, Jack P. Antel, Kee-Pyo Kim
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Elsevier, 2021, ⟨10.1016/j.stemcr.2021.03.001⟩
Stem Cell Reports, 2021, ⟨10.1016/j.stemcr.2021.03.001⟩
Stem Cell Reports, Elsevier, 2021, ⟨10.1016/j.stemcr.2021.03.001⟩
Stem Cell Reports, 2021, ⟨10.1016/j.stemcr.2021.03.001⟩
Summary Limited access to human oligodendrocytes impairs better understanding of oligodendrocyte pathology in myelin diseases. Here, we describe a method to robustly convert human fibroblasts directly into oligodendrocyte-like cells (dc-hiOLs), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf0d0735734348b24673ac23d4c684
https://doi.org/10.1016/j.stemcr.2021.03.001
https://doi.org/10.1016/j.stemcr.2021.03.001
Autor:
Mingxi Weng, Sik Y. Ho, Xiaoxiao Yang, Yanpu Chen, Derek Hoi Hang Ho, Ralf Jauch, Jian Yan, Hans R. Schöler, Johannes Graumann, Gary D. Stormo, Yogesh Srivastava, Anastasia Bednarz, Ya Gao, Yuanjie Wei, Sergiy Velychko, Thomas Braun, Daisylyn Senna Tan, Johnny Kim, Vikas Malik, Ligang Fan
Publikováno v:
Molecular Biology and Evolution
Transcription factor-driven cell fate engineering in pluripotency induction, transdifferentiation, and forward reprogramming requires efficiency, speed, and maturity for widespread adoption and clinical translation. Here, we used Oct4, Sox2, Klf4, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a59703c3bb3cce02eb205c63ea6683d
https://doi.org/10.1093/molbev/msab075
https://doi.org/10.1093/molbev/msab075
Autor:
Erik A Tolen, Le Xiong, Jinmi Choi, Sergiy Velychko, Livia Caizzi, Taras Velychko, Kenjiro Adachi, Caitlin M MacCarthy, Michael Lidschreiber, Patrick Cramer, Hans R Schöler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca9e19f99e30a5e867714e090f2dbfe3
https://doi.org/10.7554/elife.71533.sa2
https://doi.org/10.7554/elife.71533.sa2
Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells
Autor:
Erik A Tolen, Le Xiong, Jinmi Choi, Sergiy Velychko, Livia Caizzi, Taras Velychko, Kenjiro Adachi, Caitlin M MacCarthy, Michael Lidschreiber, Patrick Cramer, Hans R Schöler
Publikováno v:
eLife.
eLife
eLife
The transcription factor Oct4 is essential for the maintenance and induction of stem cell pluripotency, but its functional roles are not fully understood. Here, we investigate the functions of Oct4 by depleting and subsequently recovering it in mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eaac64b427e19cd7c4d74173e3c76aa