Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Sergiy Shtrygol"'
Autor:
Mariia Mishchenko, Sergiy Shtrygol’, Andrii Lozynskyi, Mykhailo Hoidyk, Dmytro Khyluk, Tatyana Gorbach, Roman Lesyk
Publikováno v:
Scientia Pharmaceutica, Vol 90, Iss 3, p 56 (2022)
It was determined that the studied 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) affects the cyclooxygenase pathway of the arachidonic acid cascade, the markers of damage to neurons on models of PTZ kindling. In the m
Externí odkaz:
https://doaj.org/article/82ddb42138e145f5b1f0feaf8f08196b
Autor:
Illya Podolsky, Sergiy Shtrygol’
Publikováno v:
Pharmacia, Vol 66, Iss 1, Pp 13-18 (2019)
The object of the present study, 2-methyl-3-(phenylaminomethyl)-1H-quinolin-4-one (Atristamine), has been deeply studied as a promising antidepressant with the unique spectrum of additional neuropharmacological properties. Previously, the memory-enha
Externí odkaz:
https://doaj.org/article/0fd80f5b902846dea75451b7f6961046
Autor:
Vadim Tsyvunin, Sergiy Shtrygol, Mariia Mishchenko, Iryna Ryzhenko, Diana Shtrygol, Denis Oklei
Publikováno v:
Research Journal of Pharmacy and Technology. :4241-4247
The aim of the study was to determine the effect of low doses of cardiac glycoside digoxin on the anticonvulsant effect of five classical antiepileptic drugs, sodium valproate, topiramate, levetiracetam, clonazepam and phenobarbital, under experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9da4320c45b6e559c310e95fb929f31
https://doi.org/10.52711/0974-360x.2022.00713
https://doi.org/10.52711/0974-360x.2022.00713
Autor:
Mariia Mishchenko, Sergiy Shtrygol’, Andrii Lozynskyi, Semen Khomyak, Volodymyr Novikov, Olexandr Karpenko, Serhii Holota, Roman Lesyk
Publikováno v:
Scientia Pharmaceutica, Vol 89, Iss 2, p 22 (2021)
Neuroinflammation is an integral part of epilepsy pathogenesis and other convulsive conditions, and non-steroidal anti-inflammatory drugs (NSAIDs) present a potent tool for the contemporary search and design of novel anticonvulsants. In the present p
Externí odkaz:
https://doaj.org/article/bd29597a15fa455eab44b7ff8b2a3496
Publikováno v:
ScienceRise: Pharmaceutical Science. :46-55
Inhibitors of the arachidonic acid cascade have significant potential as the agents for the prevention of severe cold injuries. The results of the previous studies have demonstrated the pronounced frigoprotective properties of certain non-steroidal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c0618eeb61ca846f2fe9c54873a10a
https://doi.org/10.15587/2519-4852.2022.255797
https://doi.org/10.15587/2519-4852.2022.255797
Publikováno v:
ScienceRise: Pharmaceutical Science. :10-17
The aim. The purpose of this review is to summarize data on the synthesis and structural modification of heterocyclic systems with triazole and thiadiazole fragments in molecules as promising objects in bioorganic and medicinal chemistry. Materials a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8514a99edaa908b969ea974d1bd26bc
https://doi.org/10.15587/2519-4852.2022.255276
https://doi.org/10.15587/2519-4852.2022.255276
Autor:
Wassim El Kayal, Hanna Severina, Vadim Tsyvunin, Sergiy Zalevskyi, Sergiy Shtrygol', Sergiy Vlasov, Olga Golovchenko, Sergiy Kovalenko, Victoriya Georgiyants
Publikováno v:
ScienceRise: Pharmaceutical Science. :58-69
The aim. Synthesis of 1-benzylsubstituted derivatives of N-[(2,4-dichlorophenyl)methyl]-2-(2,4-dioxo-1h-quinazolin-3-yl)acetamide, and determination of affinity to GABAergic biotargets with the following anticonvulsant activity estimation using PTZ-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3332868e70fa92ec4200a697c583e3
https://doi.org/10.15587/2519-4852.2022.253554
https://doi.org/10.15587/2519-4852.2022.253554
Publikováno v:
ScienceRise: Pharmaceutical Science, Iss 6 (34), Pp 58-65 (2021)
"Non-antiepileptic" drugs have a strong potential as adjuvants in multidrug-resistant epilepsy treatment. In previous study the influence of low doses of digoxin, which do not affect the myocardium, on the anticonvulsant potential of classical common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e643da49bab265dbe9d1cccd7a9ba883
http://journals.uran.ua/sr_pharm/article/view/249375
http://journals.uran.ua/sr_pharm/article/view/249375
Publikováno v:
Scientia Pharmaceutica, Vol 88, Iss 1, p 16 (2020)
Here, we describe the synthesis and anticonvulsant activity of thiazole-bearing hybrids based on 2-imino-4-thiazolidinone and 2,4-dioxothiazolidine-5-carboxylic acid cores. The structure of target compounds was based on the following: (i) A combinati
Externí odkaz:
https://doaj.org/article/b5c9947b9a8e4cfeb783517f7a055867
Autor:
Sergiy Shtrygol, Olga Tovchiga, Olesia Kudina, Olga Koiro, Tetiana Yudkevich, Tetiana Gorbach
Publikováno v:
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti. 71(5)
NSAIDs are promising agents for preventing cold injury (frigoprotectors). The influence of prophylactic administration of the non-selective COX inhibitor diclofenac sodium (7 mg/kg) and the highly selective COX-2 inhibitor etoricoxib (5 mg/kg) on cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c662fb70e2f39c1454fc335ce9201669
https://pubmed.ncbi.nlm.nih.gov/36443026
https://pubmed.ncbi.nlm.nih.gov/36443026