Výsledky vyhledávání - "Sergiy M. Yarmoluk"

Akademický článek

Discovery of novel antituberculosis agents among 3-phenyl-5-(1-phenyl-1H-[1,2,3]triazol-4-yl)-[1,2,4]oxadiazole derivatives targeting aminoacyl-tRNA synthetases

Autor: Mariia Yu. Rybak, Anatoliy O. Balanda, Anna P. Yatsyshyna, Igor. M. Kotey, Sergiy A. Starosyla, Volodymyr G. Bdzhola, Lubov L. Lukash, Sergiy M. Yarmoluk, Michael A. Tukalo, Galyna P. Volynets

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Abstract Antibiotic resistance is a major problem of tuberculosis treatment. This provides the stimulus for the search of novel molecular targets and approaches to reduce or forestall resistance emergence in Mycobacterium tuberculosis. Earlier, we di

Externí odkaz: https://doaj.org/article/2895faeaf24341efba42a3825c6db018

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Akademický článek

Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor

Autor: Karsten Niefind, Nils Bischoff, Andriy G. Golub, Volodymyr G. Bdzhola, Anatoliy O. Balanda, Andriy O. Prykhod’ko, Sergiy M. Yarmoluk

Publikováno v: Pharmaceuticals, Vol 10, Iss 1, p 9 (2017)

Protein kinase CK2 is associated with a number of human diseases, among them cancer, and is therefore a target for inhibitor development in industry and academia. Six crystal structures of either CK2α, the catalytic subunit of human protein kinase C

Externí odkaz: https://doaj.org/article/ac6521b2a6bf47a397f7e9c6a82727ec

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Identification of novel small-molecular inhibitors of Staphylococcus aureus sortase A using hybrid virtual screening

Autor: Galyna P. Volynets, Fabian Barthels, Stefan J. Hammerschmidt, Olena V. Moshynets, Sergiy S. Lukashov, Sergiy A. Starosyla, Hanna V. Vyshniakova, Olga S. Iungin, Volodymyr G. Bdzhola, Andrii O. Prykhod’ko, Anatolii R. Syniugin, Vladislav M. Sapelkin, Sergiy M. Yarmoluk, Tanja Schirmeister

Publikováno v: The Journal of Antibiotics. 75:321-332

Staphylococcus aureus is one of the most dangerous pathogens commonly associated with high levels of morbidity and mortality. Sortase A is considered as a promising molecular target for the development of antistaphylococcal agents. Using hybrid virtu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9070f741f09bac54f92b8fed82646a1
https://doi.org/10.1038/s41429-022-00524-8

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Identification of Novel Indazole-based Inhibitors of Fibroblast Growth Factor Receptor 1 (FGFR1)

Autor: Anna Iatsyshyna, Yaroslav V. Bilokin, S. S. Lukashov, Galyna P. Volynets, Volodymyr G. Bdzhola, Oleksiy Borovykov, L. L. Lukash, Sergiy M. Yarmoluk, V. S. Vdovin, Iryna Borysenko, Andrii Gryshchenko

Publikováno v: Current Enzyme Inhibition. 17:161-165

Background: Overactivity of fibroblast growth factor receptor 1 (FGFR1) is associated with various tumors, particularly breast cancer, prostate cancer, non-small-cell lung carcinoma, myeloproliferative diseases, which makes this protein kinase a prom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29dc38369d9c2f6761b7ac7a64288199
https://doi.org/10.2174/1573408017666210809102227

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Probing interactions of aminoacyl-adenylate with

Autor: Galyna P, Volynets, Olga I, Gudzera, Mariia O, Usenko, Oksana B, Gorbatiuk, Sergiy M, Yarmoluk, Michael A, Tukalo

Publikováno v: Journal of biomolecular structuredynamics.

Methionyl-tRNA synthetase (MetRS) is an attractive molecular target for antibiotic discovery. Recently, we have developed several classes of small-molecular inhibitors of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fec053c264dbc12c4079df63079dec9
https://pubmed.ncbi.nlm.nih.gov/35930324

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A computational analysis of the binding free energies of apoptosis signal-regulating kinase 1 inhibitors from different chemotypes

Autor: Sergiy M. Yarmoluk, Vladislav M. Sapelkin, Galyna P. Volynets, O. V. Savytskyi, Larysa V. Pletnova

Publikováno v: Molecular Simulation. 47:1558-1568

Apoptosis signal-regulating kinase 1 (ASK1) has recently emerged as an attractive molecular target for pharmaceutical intervention. Several classes of small-molecular ASK1 inhibitors have been identified. In this article, we analysed the binding of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4494f5da69ba81ce6a6ebe35e7858dbf
https://doi.org/10.1080/08927022.2021.1922686

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