Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Sergiy M. Kovalenko"'
Autor:
Yevhenii Vaksler, Halyna V. Hryhoriv, Vladimir V. Ivanov, Sergiy M. Kovalenko, Victoriya A. Georgiyants, Thierry Langer
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 79, Iss 3, Pp 192-200 (2023)
The title compound, C30H33N4O2F, can be obtained via a two-step synthetic scheme involving 1-benzyl-6-fluoro-4-oxo-7-(piperidin-1-yl)-1,4-dihydroquinoline-3-carbonitrile as a starting compound that undergoes substitution with hydroxylamine and subseq
Externí odkaz:
https://doaj.org/article/1864c768f2e747788d4792d214d610ef
Autor:
Yevhenii Vaksler, Halyna V. Hryhoriv, Sergiy M. Kovalenko, Lina O. Perekhoda, Victoriya A. Georgiyants
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 78, Iss 9, Pp 890-896 (2022)
The title compound, C24H26N2O4S, can be obtained via two synthetic routes. According to our investigations, the most suitable way is by the reaction of ethyl 2-bromoacetate with sodium tosylsulfinate in dry DMF. It was crystallized from methanol into
Externí odkaz:
https://doaj.org/article/b4095b55adf04c54a1768c60c0957dcd
Autor:
Aleksey D. Kravchenko, Natalia V. Pyatigorskaya, Galina E. Brkich, Larysa V. Yevsieieva, Alexander V. Kyrychenko, Sergiy M. Kovalenko
Publikováno v:
Research Results in Pharmacology, Vol 8, Iss 1, Pp 1-11 (2022)
Introduction: The discovery of novel drugs that can block the transmission of pain signals for treating the pain of various etiologies is an urgent topic in pharmaceutics. The aim of this paper is to synthesize and to investigate in vitro and in sili
Externí odkaz:
https://doaj.org/article/08057f5198e34727b77fd1ac4d139e79
Autor:
Vitaliy S. Slyusarenko, Ivan S. Koklin, Sergiy M. Kovalenko, Vladimir P. Chuev, Alexey A. Shabalin, Vladimir V. Gureev, Mikhail V. Korokin
Publikováno v:
Research Results in Pharmacology, Vol 7, Iss 4, Pp 71-79 (2021)
Introduction: The aim of the present study was to research the analgesic activity and effect of new dipharmacophore compounds consisting of substances with proven therapeutic activity, namely nebracetam–ibuprofen (NRIP), nebracetam–dexibuprofen (
Externí odkaz:
https://doaj.org/article/f4ec3e5fdb6b40c6b370994d1a65854c
Autor:
Sergiy V. Vlasov, Oleksandr V. Borysov, Hanna I. Severina, Sergiy M. Kovalenko, Tetiana P. Osolodchenko, Vitaliy S. Vlasov, Victoriya A. Georgiyants
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 19, Iss 3, Pp 15-20 (2021)
Aim. To synthesize, study the antimicrobial activity and suggest antimicrobial activity mechanism for the novel derivatives of 6-(1H-benzimidazol-2-yl)-5-methylthieno[2,3-d]pyrimidin-4(3H)-one. Results and discussion. As the result of the targeted m
Externí odkaz:
https://doaj.org/article/c248549c64f247df8e09fe7bbe25133d
Autor:
Halyna Hryhoriv, Sergiy M. Kovalenko, Marine Georgiyants, Lyudmila Sidorenko, Victoriya Georgiyants
Publikováno v:
Antibiotics, Vol 12, Iss 3, p 625 (2023)
Fluoroquinolones have been studied for more than half a century. Since the 1960s, four generations of these synthetic antibiotics have been created and successfully introduced into clinical practice. However, they are still of interest for medicinal
Externí odkaz:
https://doaj.org/article/5d2fa77532c14506ae6eb797291e21c2
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 2, Pp 134-137 (2021)
The asymmetric unit of the title compound, sodium 2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetate dihydrate, Na+·C15H14NO3−·2H2O, contains two sodium cations, two organic anions (A and B) and two water molecules. The coordination geometry
Externí odkaz:
https://doaj.org/article/3bb7ba7403d14848b9f952d2aeb86193
Autor:
Svitlana V. Shishkina, Vyacheslav N. Baumer, Sergiy M. Kovalenko, Pavel V. Trostianko, Natalya D. Bunyatyan
Publikováno v:
ACS Omega, Vol 6, Iss 4, Pp 3120-3129 (2021)
Externí odkaz:
https://doaj.org/article/8b6bf505038f49ebba15ac77a5615a1c
Autor:
Sergiy M. Kovalenko, Irina S. Konovalova, Sergiy I. Merzlikin, Vladimir P. Chuev, Dmitry V. Kravchenko
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 76, Iss 9, Pp 1407-1411 (2020)
The chiral title compound, C16H20N2O2, which can be used for producing active pharmaceutical ingredients for treatment of type 2 pancreatic diabetes and other pathologies dependent on insulin resistance, was prepared from (1R,3S)-camphoric acid and o
Externí odkaz:
https://doaj.org/article/92c41bcd3f0a49a1a0bdd48911569eb7
Autor:
Hanna I. Severina, Olga O. Skupa, Natalya I. Voloshchuk, Narzullo Saidov, Vera A. Bunyatyan, Sergiy M. Kovalenko, Victoriya A. Georgiyants
Publikováno v:
Research Results in Pharmacology, Vol 6, Iss 2, Pp 27-41 (2020)
Introduction: The search for new anticonvulsants for epilepsy treatment with higher efficacy and better tolerability remains important. The aim of the present research was an in silico and in vivo pharmacological study of N-(3,4-dimethoxyphenyl)-2-((
Externí odkaz:
https://doaj.org/article/0f3a276a980146298b692b66baf700aa