Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Sergiy M, Nadtochiy"'
Autor:
Caio Tabata Fukushima, Ian-Shika Dancil, Hannah Clary, Nidhi Shah, Sergiy M. Nadtochiy, Paul S. Brookes
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103047- (2024)
Ischemic tissues accumulate succinate, which is rapidly oxidized upon reperfusion, driving a burst of mitochondrial reactive oxygen species (ROS) generation that triggers cell death. In isolated mitochondria with succinate as the sole metabolic subst
Externí odkaz:
https://doaj.org/article/a660219d5cd04eae9638469880173663
Autor:
Gisela Beutner, Jonathan Ryan Burris, Michael P. Collins, Chaitanya A. Kulkarni, Sergiy M. Nadtochiy, Karen L. de Mesy Bentley, Ethan D. Cohen, Paul S. Brookes, George A. Porter, Jr.
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109157- (2024)
Summary: In the embryonic heart, the activation of the mitochondrial electron transport chain (ETC) coincides with the closure of the cyclophilin D (CypD) regulated mitochondrial permeability transition pore (mPTP). However, it remains to be establis
Externí odkaz:
https://doaj.org/article/a462e368f5ea459999c5d9156d652a7f
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 13 (2022)
Background The metabolite succinate accumulates during cardiac ischemia. Within 5 minutes of reperfusion, succinate returns to baseline levels via both its release from cells and oxidation by mitochondrial complex II. The latter drives reactive oxyge
Externí odkaz:
https://doaj.org/article/9215f15c122a41b89f7364e581557029
Autor:
Sergiy M. Nadtochiy, Tatsiana Stefanos, Ronald E. Angona, Nathan Darrow, C.C.P., Karen Jones, Changyong Feng, Mohamed Algahim, Dana LeMoine, Robin Westcott, Brian Anderson, Michael F. Swartz, Michael P. Eaton
Publikováno v:
Anesthesiology. 138:523-532
Background Heparin anticoagulation has been used successfully for cardiopulmonary bypass (CPB). However, an alternative anticoagulant approach is desirable due to the cases of heparin-induced thrombocytopenia. Dabigatran provides anticoagulation for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd9753e789e66b180f3a4b9b8c251f98
https://doi.org/10.1097/aln.0000000000004537
https://doi.org/10.1097/aln.0000000000004537
Publikováno v:
Journal of Molecular and Cellular Cardiology. 174:101-114
Tissue ischemia results in intracellular pH (pHIN) acidification, and while accumulation of metabolites such as lactate is a known driver of acidic pHIN, less is known about how acidic pHIN regulates metabolism. Furthermore, acidic extracellular (pHE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d442ee7a304cd1945940ef2f4df9da
https://doi.org/10.1016/j.yjmcc.2022.11.008
https://doi.org/10.1016/j.yjmcc.2022.11.008
Autor:
Chaitanya A Kulkarni, Sergiy M Nadtochiy, Leslie Kennedy, Jimmy Zhang, Sophea Chhim, Hanan Alwaseem, Elizabeth Murphy, Dragony Fu, Paul S Brookes
Publikováno v:
eLife, Vol 9 (2020)
Alkb homolog 7 (ALKBH7) is a mitochondrial α-ketoglutarate dioxygenase required for DNA alkylation-induced necrosis, but its function and substrates remain unclear. Herein, we show ALKBH7 regulates dialdehyde metabolism, which impacts the cardiac re
Externí odkaz:
https://doaj.org/article/0dc515db99d74ef0bd80e3abdb1bbe69
Publikováno v:
Pediatric Anesthesia. 32:1113-1120
Dabigatran is an anticoagulant with potential use during cardiopulmonary bypass in children and adults. The pharmacokinetic-pharmacodynamic relationship for dabigatran anticoagulation effect was investigated in an intact animal model using rabbits.Te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9419f8a47bcaf427678822cc9240f101
https://doi.org/10.1111/pan.14511
https://doi.org/10.1111/pan.14511
Autor:
Sergiy M. Nadtochiy, Tatsiana Stefanos, Ronald E. Angona, Natalie Lebedko, Aksana Baldzizhar, Changyong Feng, Michael P. Eaton
Publikováno v:
Anesthesia and analgesia. 135(1)
Heparin is the standard anticoagulant for cardiopulmonary bypass (CPB); however, there are problems with its use that make the development of suitable alternatives desirable. Currently, no ideal alternative exists. We have previously reported that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caec35d73ffa5a38b16417a288aa4cee
https://pubmed.ncbi.nlm.nih.gov/35709444
https://pubmed.ncbi.nlm.nih.gov/35709444
Autor:
Laura C Shum, Noelle S White, Sergiy M Nadtochiy, Karen L de Mesy Bentley, Paul S Brookes, Jennifer H Jonason, Roman A Eliseev
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155709 (2016)
Pathogenic factors associated with aging, such as oxidative stress and hormone depletion converge on mitochondria and impair their function via opening of the mitochondrial permeability transition pore (MPTP). The MPTP is a large non-selective pore r
Externí odkaz:
https://doaj.org/article/8cf59e506817440ebb6201ddb3ce1570
Publikováno v:
Circulation Research. 129
Succinate is a metabolite that plays a central role in ischemia-reperfusion (IR) injury,which is relevant to myocardial infarction (heart attack) and stroke. Succinateaccumulates during ischemia and is rapidly consumed at reperfusion driving reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0ab7a37f725465004191ac2adc192c4
https://doi.org/10.1161/res.129.suppl_1.p311
https://doi.org/10.1161/res.129.suppl_1.p311