Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sergiy Libert"'
Autor:
Timothy M. Robinette, Justin W. Nicholatos, Adam B. Francisco, Kayla E. Brooks, Rachel Y. Diao, Sandro Sorbi, Valdo Ricca, Benedetta Nacmias, Miguel A. Brieño-Enríquez, Sergiy Libert
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Anorexia nervosa is an eating disorder characterized by fear of gaining weight that can lead to serious complications. Here the authors show that inhibition of SIRT1 is protective against the onset and progression of anorectic behavior in an activity
Externí odkaz:
https://doaj.org/article/e2920cd71a6c4de88a51804d31fe2360
Autor:
Justin W. Nicholatos, Adam B. Francisco, Carolyn A. Bender, Tiffany Yeh, Fraz J. Lugay, Jairo E. Salazar, Christin Glorioso, Sergiy Libert
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-18 (2018)
Abstract Parkinson’s disease is characterized by progressive death of dopaminergic neurons, leading to motor and cognitive dysfunction. Epidemiological studies consistently show that the use of tobacco reduces the risk of Parkinson’s. We report t
Externí odkaz:
https://doaj.org/article/6c8cb82a58ce4ca7a9af1c35a8dcc585
Why people age at different rates is a fundamental unsolved problem in biology. We created a model that predicts an individual’s age, taking as input physiological traits that change with age in the large UK Biobank dataset, such as blood pressure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cbc5e8af372062f6d135c7659196981
https://doi.org/10.1101/2022.04.14.488358
https://doi.org/10.1101/2022.04.14.488358
Autor:
Timothy M. Robinette, Sergiy Libert
Publikováno v:
Aging (Albany NY)
Autor:
Michael P. Murphy, James F. Nelson, Elizabeth Fernandez, Arlan Richardson, David E. Harrison, Richard A. Miller, Peter Reifsnyder, Molly A. Bogue, Adam B. Salmon, Martin A. Javors, Nicolas Musi, Randy Strong, Michael Petrascheck, Paul Anthony Marinez, Francesca Macchiarini, Sergiy Libert
Publikováno v:
Aging Cell
To see if variations in timing of rapamycin (Rapa), administered to middle aged mice starting at 20 months, would lead to different survival outcomes, we compared three dosing regimens. Initiation of Rapa at 42 ppm increased survival significantly in
Autor:
Adam B. Francisco, Rachel Y. Diao, Timothy M. Robinette, Sergiy Libert, Sandro Sorbi, Justin W. Nicholatos, Benedetta Nacmias, Valdo Ricca, Miguel A. Brieño-Enríquez, Kayla E. Brooks
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Food consumption is fundamental for life, and eating disorders often result in devastating or life-threatening conditions. Anorexia nervosa (AN) is characterized by a persistent restriction of energy intake, leading to lowered body weight, constant f
Autor:
Yehudit Zaltsman, Siu Sylvia Lee, Michael Platov, Sergiy Libert, Atan Gross, Antonella Ruggiero, Adam B. Francisco, Veerle Rottiers
Publikováno v:
Obesity. 25:616-625
Objective More than one-third of U.S. adults have obesity, causing an alarming increase in obesity-related comorbidities such as type 2 diabetes. The functional role of mitochondrial carrier homolog 2 (MTCH2), a human obesity-associated gene, in lipi
Autor:
Frank K. Huynh, Olga Ilkayeva, Matthew D. Hirschey, Richard A. Miller, Timothy M. Robinette, Igor M. Sokolov, Justin W. Nicholatos, Saurabh V.P. Tata, Sergiy Libert, Maxim Dokukin, Michael Platov, Michael A. Weinstein, Dmyro Volkov, Adam R. Boyko, Adam B. Francisco, Jennifer D. Yordy
Publikováno v:
SSRN Electronic Journal.
Among its many breeds, dogs exhibit exceptional variation in their rate of aging and average lifespan, which presents an opportunity to identify longevity-associated traits via comparative analysis. Using primary dermal fibroblasts, we investigated m
Apoptosis is essential for numerous processes, such as development, resistance to infections, and suppression of tumorigenesis. Here, we investigate the influence of the nutrient sensing and longevity-assuring enzyme SIRT6 on the dynamics of apoptosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89ed1902c25698c522d9e0a1e00e4d2
We describe a 3D percolation-type approach to modeling of the processes of aging and certain other properties of tissues analyzed as systems consisting of interacting cells. Lattice sites are designated as regular (healthy) cells, senescent cells, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7ff35243e73b141d37b6f78122f1b9