Výsledky vyhledávání - "Sergiy Krasutsky"

Isoprenoidbiosynthese in pathogenen Bakterien: Nukleare inelastische Streuung ermöglicht Einblicke in den ungewöhnlichen [4Fe-4S]-Cluster vomE.-coli-Protein LytB/IspH

Autor: Annegret Reinhard, C. Dale Poulter, Hans-Christian Wille, Myriam Seemann, Juliusz A. Wolny, Isabelle Faus, Volker Schünemann, S. Rackwitz, Kai Schlage, Philippe Chaignon, Aleksandr I. Chumakov, Sergiy Krasutsky

Publikováno v: Angewandte Chemie. 127:12771-12775

Das Protein LytB/ISPH katalysiert den letzten Schritt des Methylerythritolphosphat(MEP)-Wegs, der zur Terpenoidbiosynthese in vielen pathogenen Bakterien dient. Deswegen gilt der MEP-Weg als Angriffspunkt fur neue potentielle Antibiotika, da er essen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c22c292a13eb43ddcc0910949951ec7d
https://doi.org/10.1002/ange.201502494

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Isoprenoid Biosynthesis in Pathogenic Bacteria: Nuclear Resonance Vibrational Spectroscopy Provides Insight into the Unusual [4Fe-4S] Cluster of theE. coliLytB/IspH Protein

Autor: Isabelle Faus, Juliusz A. Wolny, S. Rackwitz, Kai Schlage, Hans-Christian Wille, Sergiy Krasutsky, C. Dale Poulter, Aleksandr I. Chumakov, Annegret Reinhard, Volker Schünemann, Philippe Chaignon, Myriam Seemann

Publikováno v: Angewandte Chemie International Edition. 54:12584-12587

The LytB/IspH protein catalyzes the last step of the methylerythritol phosphate (MEP) pathway which is used for the biosynthesis of essential terpenoids in most pathogenic bacteria. Therefore, the MEP pathway is a target for the development of new an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94deae195901661a89a421621440725
https://doi.org/10.1002/anie.201502494

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Synthesis of Methylerythritol Phosphate Analogues and Their Evaluation as Alternate Substrates for IspDF and IspE from Agrobacterium tumefaciens

Autor: Robert M. Coates, C. Dale Poulter, Marek Urbansky, Chad E. Davis, Christian Lherbet, Sergiy Krasutsky

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2014, 79 (19), pp.9170-9178. ⟨10.1021/jo501529k⟩
The Journal of Organic Chemistry

The methylerythritol phosphate biosynthetic pathway, found in most Bacteria, some parasitic protists, and plant chloroplasts, converts D-glyceraldehyde phosphate and pyruvate to isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cb167bed8fc9d324c756ed546d8b05
https://doi.org/10.1021/jo501529k

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Inhibition of IspH, a [4Fe–4S]2+ Enzyme Involved in the Biosynthesis of Isoprenoids via the Methylerythritol Phosphate Pathway

Autor: Myriam Seemann, Sergiy Krasutsky, Philippe Chaignon, C. Dale Poulter, Michel Rohmer, Karnjapan Janthawornpong

Publikováno v: Journal of the American Chemical Society. 135:1816-1822

The MEP pathway, which is absent in animals but present in most pathogenic bacteria, in the parasite responsible for malaria and in plant plastids, is a target for the development of antimicrobial drugs. IspH, an oxygen-sensitive [4Fe–4S] enzyme, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee49f2ce722f6c07f9f8361f718a7608
https://doi.org/10.1021/ja309557s

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