Výsledky vyhledávání - "Sergio Villordo"

Zika Virus Subgenomic Flavivirus RNA Generation Requires Cooperativity between Duplicated RNA Structures That Are Essential for Productive Infection in Human Cells

Autor: Maria-Carla Saleh, Sergio Villordo, Maria A. Morales, Cintia Fabri, Horacio M. Pallarés, Annabelle Henrion-Lacritick, Luana de Borba, Fernando Merwaiss, Guadalupe S. Costa Navarro, María Mora González López Ledesma, Andrea V. Gamarnik, Diego Sebastian Ojeda

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2020, 94 (18), ⟨10.1128/JVI.00343-20⟩
J Virol
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Journal of Virology, 2020, 94 (18), ⟨10.1128/JVI.00343-20⟩

Zika virus (ZIKV) is an emerging flavivirus, mainly transmitted by mosquitoes, which represents a global health threat. A common feature of flavivirus-infected cells is the accumulation of viral noncoding subgenomic RNAs by partial degradation of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d5d4298c257d68c0290b8dae1af308
https://hal-pasteur.archives-ouvertes.fr/pasteur-03260681

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RNA Structure Duplication in the Dengue Virus 3 ' UTR: Redundancy or Host Specificity?

Autor: Leopoldo German Gebhard, Sergio Villordo, Juan Manuel Carballeda, Louis Lambrechts, Franco Leonel Marsico, Andrea V. Gamarnik, Claudia Veronica Filomatori, Sebastian Lequime, Carol D. Blair, Horacio M. Pallarés, Luana de Borba, Irma Sanchez Vargas

Publikováno v: mBio
mBio, 2019, 10 (1), pp.e02506-18. ⟨10.1128/mBio.02506-18⟩
mBio, Vol 10, Iss 1 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
mBio, American Society for Microbiology, 2019, 10 (1), pp.e02506-18. ⟨10.1128/mBio.02506-18⟩
mBio, Vol 10, Iss 1, p e02506-18 (2019)

Flaviviruses constitute the most relevant group of arthropod-transmitted viruses, including important human pathogens such as the dengue, Zika, yellow fever, and West Nile viruses. The natural alternation of these viruses between vertebrate and inver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9020e25da46165b778c9e046200a19
https://lirias.kuleuven.be/handle/123456789/633029

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Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells

Autor: Horacio M. Pallarés, Sebastian Aguirre, Cintia Fabri, Claudia Veronica Filomatori, Juan Manuel Carballeda, Andrea V. Gamarnik, Maria A. Morales, Ana M. Maestre, Irma Sanchez-Vargas, Sergio Villordo, Carol D. Blair, Ana Fernandez-Sesma

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 3, p e1006265 (2017)

The Flavivirus genus includes a large number of medically relevant pathogens that cycle between humans and arthropods. This host alternation imposes a selective pressure on the viral population. Here, we found that dengue virus, the most important vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569afc5eb368fbe103659f5a7d1f98a6
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006265

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Differential RNA Sequence Requirement for Dengue Virus Replication in Mosquito and Mammalian Cells

Autor: Andrea V. Gamarnik, Sergio Villordo

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Dengue virus cycles between mosquitoes and humans. Each host provides a different environment for viral replication, imposing different selective pressures. We identified a sequence in the dengue virus genome that is essential for viral replication i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f032ad5224c9dddafdc524c78d191a
https://doi.org/10.1128/jvi.00567-13

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RNA Structure Duplications and Flavivirus Host Adaptation

Autor: Claudia Veronica Filomatori, Sergio Villordo, Andrea V. Gamarnik, Juan Manuel Carballeda

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Flaviviruses include a highly diverse group of arboviruses with a global distribution and a high human disease burden. Most flaviviruses cycle between insects and vertebrate hosts; thus, they are obligated to use different cellular machinery for thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6e308eb9d3093b17beed7cd8853e7b
http://www.sciencedirect.com/science/article/pii/S0966842X16000147

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RNA Sequences and Structures Required for the Recruitment and Activity of the Dengue Virus Polymerase

Autor: Diego E. Alvarez, Andrea V. Gamarnik, Sergio Villordo, Claudia Veronica Filomatori, Nestor Gabriel Iglesias

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Dengue virus RNA-dependent RNA polymerase specifically binds to the viral genome by interacting with a promoter element known as stem-loop A (SLA). Although a great deal has been learned in recent years about the function of this promoter in dengue v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdc089a8f40fd391098f2a99e91104a
https://doi.org/10.1074/jbc.m110.162289

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A balance between circular and linear forms of the dengue virus genome is crucial for viral replication

Autor: Diego E. Alvarez, Andrea V. Gamarnik, Sergio Villordo

Publikováno v: RNA

The plasticity of viral plus strand RNA genomes is fundamental for the multiple functions of these molecules. Local and long-range RNA - RNA interactions provide the scaffold for interacting proteins of the translation, replication, and encapsidation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bc9c4b953fafd8e3822466b0794494

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Overlapping local and long-range RNA-RNA interactions modulate dengue virus genome cyclization and replication

Autor: Leopoldo German Gebhard, Sergio Villordo, Andrea V. Gamarnik, Claudia Veronica Filomatori, Luana de Borba, Nestor Gabriel Iglesias

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The dengue virus genome is a dynamic molecule that adopts different conformations in the infected cell. Here, using RNA folding predictions, chemical probing analysis, RNA binding assays, and functional studies, we identified new cis-acting elements

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fdf855165b4286aca442699af6b038
http://jvi.asm.org/content/89/6/3430

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Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality

Autor: Sergio Villordo, Laura Morelli, Maria Celeste Leal, Natalia Magnani, Eduardo M. Castaño, Pablo Evelson, Cristina Marino Buslje

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Studies of post-mortem brains from Alzheimer disease patients suggest that oxidative damage induced by mitochondrial amyloid β (mitAβ) accumulation is associated with mitochondrial dysfunction. However, the regulation of mitAβ metabolism is unknow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad3665ae5021e2109f29d51d66acf3a
http://www.jbc.org/content/288/18/12920.long

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Genome Cyclization as Strategy for Flavivirus RNA Replication

Autor: Andrea V. Gamarnik, Sergio Villordo

Long-range and local RNA-RNA contacts in viral RNA genomes result in tertiary structures that modulate the function of enhancers, promoters, and silencers during translation, RNA replication, and encapsidation. In the case of flaviviruses, the presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e40593d7d9540df8e6424f2d2cc6e4
https://europepmc.org/articles/PMC5440119/

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