Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Sergio Verjovski-Almeida"'
Autor:
Daisy Woellner-Santos, Ana C. Tahira, João V. M. Malvezzi, Vinicius Mesel, David A. Morales-Vicente, Monalisa M. Trentini, Lázaro M. Marques-Neto, Isaac A. Matos, Alex I. Kanno, Adriana S. A. Pereira, André A. R. Teixeira, Ricardo J. Giordano, Luciana C. C. Leite, Carlos A. B. Pereira, Ricardo DeMarco, Murilo S. Amaral, Sergio Verjovski-Almeida
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-19 (2024)
Abstract Schistosomiasis, a challenging neglected tropical disease, affects millions of people worldwide. Developing a prophylactic vaccine against Schistosoma mansoni has been hindered by the parasite’s biological complexity. In this study, we uti
Externí odkaz:
https://doaj.org/article/3538479b2fca4d06b0fefa7e31cf9fdf
Autor:
Pedro Jardim Poli, Agatha Fischer-Carvalho, Ana Carolina Tahira, John D. Chan, Sergio Verjovski-Almeida, Murilo Sena Amaral
Publikováno v:
Non-Coding RNA, Vol 10, Iss 2, p 27 (2024)
Schistosomiasis is a disease caused by trematodes of the genus Schistosoma that affects over 200 million people worldwide. For decades, praziquantel (PZQ) has been the only available drug to treat the disease. Despite recent discoveries that identifi
Externí odkaz:
https://doaj.org/article/e4d90930352f4298be7d5c82e5802381
Autor:
Gilbert O Silveira, Helena S Coelho, Adriana S A Pereira, Patrícia A Miyasato, Daisy W Santos, Lucas F Maciel, Giovanna G G Olberg, Ana C Tahira, Eliana Nakano, Maria Leonor S Oliveira, Murilo S Amaral, Sergio Verjovski-Almeida
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011369 (2023)
The trematode parasite Schistosoma mansoni causes schistosomiasis, which affects over 200 million people worldwide. Schistosomes are dioecious, with egg laying depending on the females' obligatory pairing with males. Long non-coding RNAs (lncRNAs) ar
Externí odkaz:
https://doaj.org/article/cbe44d662e964f55a99e953fb09f94cc
Autor:
Ednilson Hilário Lopes-Junior, Claudio Romero Bertevello, Gilbert de Oliveira Silveira, Camila Banca Guedes, Gratchela Dutra Rodrigues, Viviane Sousa Ribeiro, Murilo Sena Amaral, Cristina Takami Kanamura, Pedro Luiz Silva Pinto, Rodrigo Ferreira Krüger, Sergio Verjovski-Almeida, Katia Cristina Oliveira
Publikováno v:
Parasites & Vectors, Vol 15, Iss 1, Pp 1-9 (2022)
Abstract Several studies have described the effects of human tumor necrosis factor alpha (hTNF-α) on Schistosoma mansoni. hTNF-α affects the worm’s development, metabolism, egg-laying, gene expression and protein phosphorylation. The available da
Externí odkaz:
https://doaj.org/article/7577d25de66c4be7bc7a2d67e78505ee
Autor:
Gisele Fernanda Assine Picchi-Constante, Eloise Pavão Guerra-Slompo, Ana Carolina Tahira, Monica Visnieski Alcantara, Murilo Sena Amaral, Arthur Schveitzer Ferreira, Michel Batista, Cassiano Martin Batista, Samuel Goldenberg, Sergio Verjovski-Almeida, Nilson Ivo Tonin Zanchin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Trypanosoma cruzi—the causative agent of Chagas disease—like other kinetoplastids, relies mostly on post-transcriptional mechanisms for regulation of gene expression. However, trypanosomatids undergo drastic changes in nuclear architectu
Externí odkaz:
https://doaj.org/article/096465a371e64559b0aaba9b89558b88
Autor:
Murilo Sena Amaral, Daisy Woellner Santos, Adriana S. A. Pereira, Ana Carolina Tahira, João V. M. Malvezzi, Patrícia Aoki Miyasato, Rafaela de Paula Freitas, Jorge Kalil, Elisa M. Tjon Kon Fat, Claudia J. de Dood, Paul L. A. M. Corstjens, Govert J. van Dam, Eliana Nakano, Simone de Oliveira Castro, Vânia Gomes de Moura Mattaraia, Ronaldo de Carvalho Augusto, Christoph Grunau, R. Alan Wilson, Sergio Verjovski-Almeida
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
To date there is only one single drug with modest efficacy and no vaccine available to protect from schistosomiasis. Here, Amaral et al. characterize the self-cure process of rhesus macaques following primary infection and secondary challenge with Sc
Externí odkaz:
https://doaj.org/article/e9d55c826fc24303807d391082e54ddd
Autor:
David A. Morales-Vicente, Lu Zhao, Gilbert O. Silveira, Ana C. Tahira, Murilo S. Amaral, James J. Collins, Sergio Verjovski-Almeida
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Schistosoma mansoni is a flatworm that causes schistosomiasis, a neglected tropical disease that affects over 200 million people worldwide. New therapeutic targets are needed with only one drug available for treatment and no vaccine. Long non-coding
Externí odkaz:
https://doaj.org/article/eb6cbefa830a40d781f8371bbaea9b7a
Autor:
Gilbert O. Silveira, Murilo S. Amaral, Helena S. Coelho, Lucas F. Maciel, Adriana S. A. Pereira, Giovanna G. O. Olberg, Patricia A. Miyasato, Eliana Nakano, Sergio Verjovski-Almeida
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) is the most used, fast, and reproducible method to confirm large-scale gene expression data. The use of stable reference genes for the normalization of RT-qPCR
Externí odkaz:
https://doaj.org/article/e3e22ccbe69e4880829662ea5ea2957f
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-16 (2021)
Abstract Background Androgen receptor (AR) and polycomb repressive complex 2 (PRC2) are known to co-occupy the loci of genes that are downregulated by androgen-stimulus. Long intergenic non-coding RNA (lincRNA) PVT1 is an overexpressed oncogene that
Externí odkaz:
https://doaj.org/article/cbe5607e2dae41c188def6d7f3a89a15
Autor:
Murilo S. Amaral, Lucas F. Maciel, Gilbert O. Silveira, Giovanna G. O. Olberg, João V. P. Leite, Lucas K. Imamura, Adriana S. A. Pereira, Patricia A. Miyasato, Eliana Nakano, Sergio Verjovski-Almeida
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Schistosoma mansoni is a flatworm that causes schistosomiasis, a neglected tropical disease that affects more than 200 million people worldwide. There is only one drug indicated for treatment, praziquantel, which may lead to parasite resista
Externí odkaz:
https://doaj.org/article/d5c3edb898084192917b2e847a1a6d94