The Noradrenergic System in Parkinson’s Disease

Autor: Elena Paredes-Rodriguez, Sergio Vegas-Suarez, Teresa Morera-Herreras, Philippe De Deurwaerdere, Cristina Miguelez

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

Nowadays it is well accepted that in Parkinson’s disease (PD), the neurodegenerative process occurs in stages and that damage to other areas precedes the neuronal loss in the substantia nigra pars compacta, which is considered a pathophysiological

Externí odkaz: https://doaj.org/article/ad1c40c4f227448dbf5395d524510747

6-Hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in the substantia nigra pars reticulata

Autor: Clarissa Anna Pisanò, Harkaitz Bengoetxea, Catalina Requejo, Michele Morari, José Vicente Lafuente, Cristina Miguelez, Luisa Ugedo, Sergio Vegas-Suarez

Publikováno v: Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
British Journal of Pharmacology
Addi. Archivo Digital para la Docencia y la Investigación
instname

Background and Purpose l-DOPA-induced dyskinesia (LID) is considered a major complication in the treatment of Parkinson's disease (PD). Buspirone (5-HT(1A)partial agonist) have shown promising results in the treatment of PD and LID, however no 5-HT-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62193f03edfecb32d5e9376e90812d4
http://hdl.handle.net/11392/2471960

Dysfunction of serotonergic neurons in Parkinson's disease and dyskinesia

Autor: Luisa Ugedo, Asier Aristieta, José Vicente Lafuente, Elena Paredes-Rodriguez, Cristina Miguelez, Sergio Vegas-Suarez

Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra, the depletion of striatal dopamine and the presence of Lewy aggregates containing alpha-synuclein. Clinically, there are motor impairments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16d9ca24495719ee2fc05b4c31b55d9b
https://doi.org/10.1016/bs.irn.2019.06.013

Metabolic Diffusion in Neuropathologies: The Relevance of Brain-Liver Axis

Autor: Sergio Vegas-Suárez, Jorge Simón, María Luz Martínez-Chantar, Rosario Moratalla

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Chronic liver diseases include a broad group of hepatic disorders from different etiologies and with varying degrees of progression and severity. Among them, non-alcoholic fatty (NAFLD) and alcoholic (ALD) liver diseases are the most frequent forms o

Externí odkaz: https://doaj.org/article/330641f91fdd487ca0b9b237d3ac3135