Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sergio Valbuena"'
Autor:
Xinli Xu, Rui O. Beleza, Francisco Q. Gonçalves, Sergio Valbuena, Sofia Alçada-Morais, Nélio Gonçalves, Joana Magalhães, João M. M. Rocha, Sofia Ferreira, Ana S. G. Figueira, Juan Lerma, Rodrigo A. Cunha, Ricardo J. Rodrigues, Joana M. Marques
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber (MF) sprouting found in diseases such as temporal lobe epilepsy. T
Externí odkaz:
https://doaj.org/article/eb8f8fcddb564941b72eac2840610363
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Exaggerated synaptic inhibition is hypothesised to be a main cause of cognitive deficits in Down syndrome models. The authors identify triplication of the kainate receptor encoding gene Grik1 as the cause of memory deficits due to a reorganization of
Externí odkaz:
https://doaj.org/article/d263a07d71f248b588f195680de08d05
Autor:
Mercè Izquierdo-Serra, Antoni Bautista-Barrufet, Ana Trapero, Aida Garrido-Charles, Ariadna Díaz-Tahoces, Nuria Camarero, Silvia Pittolo, Sergio Valbuena, Ariadna Pérez-Jiménez, Marina Gay, Alejandro García-Moll, Carles Rodríguez-Escrich, Juan Lerma, Pedro de la Villa, Eduardo Fernández, Miquel À Pericàs, Amadeu Llebaria, Pau Gorostiza
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Biological activity can be photoswitched by light-regulated drugs, but so far only diffusible ligands have been shown to work on endogenous receptors. Here the authors develop targeted covalent photoswitches that couple to a protein target by ligand
Externí odkaz:
https://doaj.org/article/b0268ba0adfb40789719ddb649b48d0f
Autor:
Xinli, Xu, Rui O, Beleza, Francisco Q, Gonçalves, Sergio, Valbuena, Sofia, Alçada-Morais, Nélio, Gonçalves, Joana, Magalhães, João M M, Rocha, Sofia, Ferreira, Ana S G, Figueira, Juan, Lerma, Rodrigo A, Cunha, Ricardo J, Rodrigues, Joana M, Marques
Publikováno v:
Scientific reports. 12(1)
The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber (MF) sprouting found in diseases such as temporal lobe epilepsy. The molecu
Autor:
Sergio Valbuena, Juan Lerma
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
This article is part of a Special Issue entitled: Synaptic plasticity.
Extensive research over the past decades has characterized multiple forms of synaptic plasticity, identifying them as key processes that allow the brain to operate in a dynam
Extensive research over the past decades has characterized multiple forms of synaptic plasticity, identifying them as key processes that allow the brain to operate in a dynam
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Overinhibition is assumed one of the main causes of cognitive deficits (e.g. memory impairment) in mouse models of Down syndrome (DS). Yet the mechanisms that drive such exaggerated synaptic inhibition and their behavioral effects remain unclear. Her
Autor:
Sebastian Krüttner, Antonio Falasconi, Sergio Valbuena, Ivan Galimberti, Tewis Bouwmeester, Silvia Arber, Pico Caroni
Publikováno v:
Neuron
Autism spectrum disorder (ASD) involves genetic and environmental components. The underlying circuit mechanisms are unclear, but behaviorally, aversion toward unfamiliarity, a hallmark of autism, might be involved. Here, we show that in Shank3; ΔC/
Autor:
Sergio Valbuena, Juan Lerma
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Cognition and behavior are tightly linked to synaptic function. A growing body of evidence suggests that aberrant neurotransmission, caused by changes in synaptic protein expression levels, may be a major cause underlying different brain disorders. T
Publikováno v:
Ambiociencias. :22-32
La Astrobiología es la parte de la Astronomía que busca respuesta a preguntas tales como el origen de la vida o la posibilidad de encontrar seres vivos en otros lugares del Universo. Se trata de una ciencia interdisciplinar que se desarrolla aunand
Publikováno v:
IBRO Reports. 6:S29