Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sergio Trillo-Muyo"'
Autor:
Christian V. Recktenwald, Göran Karlsson, Maria-Jose Garcia-Bonete, Gergely Katona, Maja Jensen, Richard Lymer, Malin Bäckström, Malin E.V. Johansson, Gunnar C. Hansson, Sergio Trillo-Muyo
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114207- (2024)
Summary: The MUC2 mucin protects the colonic epithelium by a two-layered mucus with an inner attached bacteria-free layer and an outer layer harboring commensal bacteria. CysD domains are 100 amino-acid-long sequences containing 10 cysteines that sep
Externí odkaz:
https://doaj.org/article/9cf85ba6d78a4dee8ce486d5c3a77539
Autor:
Pablo Gallego, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Christian V. Recktenwald, Malin E. V. Johansson, Gunnar C. Hansson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
The MUC2 mucin is a large, highly glycosylated polymer that builds the intestinal mucus. Here, the authors generate a high-resolution structural model of the 800 amino acid C-terminal dimer including its glycans. Stabilization is achieved by interdim
Externí odkaz:
https://doaj.org/article/9ee9726a35af4a11b7c5bc17fa87abe1
Autor:
Weixiao Yuan Wahlgren, Elin Claesson, Iida Tuure, Sergio Trillo-Muyo, Szabolcs Bódizs, Janne A. Ihalainen, Heikki Takala, Sebastian Westenhoff
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
In this study, authors have solved cryo-EM structures of a bacteriophytochrome in its dark-adapted and illuminated states. The structures reveal the structural mechanism for photoactivation of the phytochrome.
Externí odkaz:
https://doaj.org/article/693c598e76024a2d9df201f103fc3a8c
Autor:
Erik Ehrencrona, Christian V. Recktenwald, Sergio Trillo-Muyo, Malin Bäckström, Pablo Gallego, Malin Johansson, Maria-Jose Garcia-Bonete, Ana M. Rodríguez-Piñeiro, Sjoerd van der Post, Gunnar C. Hansson
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry
Mucus forms an important protective barrier that minimizes bacterial contact with the colonic epithelium. Intestinal mucus is organized in a complex network with several specific proteins, including the mucin-2 (MUC2) and the abundant IgGFc-binding p
Autor:
Ana M. Rodríguez-Piñeiro, Christopher M. Evans, Dalia Fakih, Anna Ermund, Sergio Trillo-Muyo, Gunnar C. Hansson
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology
Am J Physiol Lung Cell Mol Physiol
Am J Physiol Lung Cell Mol Physiol
The organization of the normal airway mucus system differs in small experimental animals from that in humans and large mammals. To address normal murine airway mucociliary clearance, Alcian blue-stained mucus transport was measured ex vivo on trachea
The respiratory system is protected from inhaled particles and microbes by the mucociliary system. This system differs between animal species, where pigs and humans have numerous submucosal glands. The polymer-forming mucin, MUC5B, is packed in a hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9f79f6befbd0175bdb37dee4a8900a
https://europepmc.org/articles/PMC6855098/
https://europepmc.org/articles/PMC6855098/
Autor:
Sergio, Trillo-Muyo, Harriet E, Nilsson, Christian V, Recktenwald, Anna, Ermund, Caroline, Ridley, Lauren N, Meiss, Andrea, Bähr, Nikolai, Klymiuk, Jeffrey J, Wine, Philip J B, Koeck, David J, Thornton, Hans, Hebert, Gunnar C, Hansson
Publikováno v:
The Journal of Biological Chemistry
Most MUC5B mucin polymers in the upper airways of humans and pigs are produced by submucosal glands. MUC5B forms N-terminal covalent dimers that are further packed into larger assemblies because of low pH and high Ca2+ in the secretory granule of the
Autor:
Anna, Ermund, Lauren N, Meiss, Ana M, Rodriguez-Pineiro, Andrea, Bähr, Harriet E, Nilsson, Sergio, Trillo-Muyo, Caroline, Ridley, David J, Thornton, Jeffrey J, Wine, Hans, Hebert, Nikolai, Klymiuk, Gunnar C, Hansson
Publikováno v:
Biochemical and Biophysical Research Communications
To understand the mucociliary clearance system, mucins were visualized by light, confocal and electron microscopy, and mucus was stained by Alcian blue and tracked by video microscopy on tracheal explants of newborn piglets. We observed long linear m