Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Sergio T. Ferreira"'
Autor:
Alinny R. Isaac, Mariana G. Chauvet, Ricardo Lima-Filho, Beatriz de A. Wagner, Bruno G. Caroli, Renata E. P. Leite, Claudia K. Suemoto, Paula Villela Nunes, Fernanda G. De Felice, Sergio T. Ferreira, Mychael V. Lourenco
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Major depressive disorder (MDD) is a significant cause of disability in adults worldwide. However, the underlying causes and mechanisms of MDD are not fully understood, and many patients are refractory to available therapeutic options. Impai
Externí odkaz:
https://doaj.org/article/00a284daaf5a498985eae3582d1517e8
Autor:
Felipe C. Ribeiro, Danielle Cozachenco, Luana Heimfarth, Juliana T. S. Fortuna, Guilherme B. de Freitas, Jorge M. de Sousa, Soniza V. Alves-Leon, Renata E. P. Leite, Claudia K. Suemoto, Lea T. Grinberg, Fernanda G. De Felice, Mychael V. Lourenco, Sergio T. Ferreira
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract The proteasome plays key roles in synaptic plasticity and memory by regulating protein turnover, quality control, and elimination of oxidized/misfolded proteins. Here, we investigate proteasome function and localization at synapses in Alzhei
Externí odkaz:
https://doaj.org/article/bdf4804051b140dd9c552fb96120595a
Autor:
Patrick R. Suman, Lisiane S. Souza, Grasielle C. Kincheski, Helen M. Melo, Mariana N. Machado, Giovanna M. C. Carvalho, Fernanda G. De Felice, Walter A. Zin, Sergio T. Ferreira
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Background Considerable evidence indicates that a signaling crosstalk between the brain and periphery plays important roles in neurological disorders, and that both acute and chronic peripheral inflammation can produce brain changes leading
Externí odkaz:
https://doaj.org/article/8d24b117abc04820ace94365f0d86b69
Autor:
Fabricio A. Pamplona, Gabriela Vitória, Felipe K. Sudo, Felipe C. Ribeiro, Alinny R. Isaac, Carolina A. Moraes, Mariana G. Chauvet, Pitia Flores Ledur, Karina Karmirian, Isis M. Ornelas, Luciana M. Leo, Bruna Paulsen, Gabriel Coutinho, Claudia Drummond, Naima Assunção, Bart Vanderborght, Claudio A. Canetti, Hugo C. Castro-Faria-Neto, Paulo Mattos, Sergio T. Ferreira, Stevens K. Rehen, Fernando A. Bozza, Mychael V. Lourenco, Fernanda Tovar-Moll
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Age increases the risk for cognitive impairment and is the single major risk factor for Alzheimer’s disease (AD), the most prevalent form of dementia in the elderly. The pathophysiological processes triggered by aging that render the brain
Externí odkaz:
https://doaj.org/article/223c09f5661f4ecea1670a848dcc0279
Autor:
Maria Clara Selles, Juliana T.S. Fortuna, Yasmin P.R. de Faria, Luciana Domett Siqueira, Ricardo Lima-Filho, Beatriz M. Longo, Robert C. Froemke, Moses V. Chao, Sergio T. Ferreira
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106545- (2023)
Summary: Alzheimer’s disease (AD) is characterized by neurodegeneration, memory loss, and social withdrawal. Brain inflammation has emerged as a key pathogenic mechanism in AD. We hypothesized that oxytocin, a pro-social hypothalamic neuropeptide w
Externí odkaz:
https://doaj.org/article/ee4e2421c80a46379724f195de1a91bd
Autor:
Mychael V. Lourenco, Guilherme B. de Freitas, Ícaro Raony, Sergio T. Ferreira, Fernanda G. De Felice
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Physical exercise stimulates neuroprotective pathways, has pro-cognitive actions, and alleviates memory impairment in Alzheimer’s disease (AD). Irisin is an exercise-linked hormone produced by cleavage of fibronectin type III domain containing prot
Externí odkaz:
https://doaj.org/article/5dbc1562f2734bb48a28bef392bfba9c
Autor:
Natalia M. Lyra e Silva, Rafaella A. Gonçalves, Tharick A. Pascoal, Ricardo A. S. Lima-Filho, Elisa de Paula França Resende, Erica L. M. Vieira, Antonio L. Teixeira, Leonardo C. de Souza, Julyanna A. Peny, Juliana T. S. Fortuna, Isadora C. Furigo, Debora Hashiguchi, Vivian S. Miya-Coreixas, Julia R. Clarke, Jose F. Abisambra, Beatriz M. Longo, Jose Donato, Paul E. Fraser, Pedro Rosa-Neto, Paulo Caramelli, Sergio T. Ferreira, Fernanda G. De Felice
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Alzheimer’s disease (AD) is associated with memory impairment and altered peripheral metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery metabolic axis plays a role in AD pathophysiology. The activation of
Externí odkaz:
https://doaj.org/article/17556201da0949e79e2b1a92c14e9d0c
Autor:
Andre F. Batista, Tayná Rody, Leticia Forny-Germano, Suzana Cerdeiro, Maria Bellio, Sergio T. Ferreira, Douglas P. Munoz, Fernanda G. De Felice
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background The lack of effective treatments for Alzheimer’s disease (AD) reflects an incomplete understanding of disease mechanisms. Alterations in proteins involved in mitochondrial dynamics, an essential process for mitochondrial integri
Externí odkaz:
https://doaj.org/article/cc6c1c09fc184286be9a8c2af099ddb3
Autor:
Victor Bodart-Santos, Luiza R. P. de Carvalho, Mariana A. de Godoy, André F. Batista, Leonardo M. Saraiva, Luize G. Lima, Carla Andreia Abreu, Fernanda G. De Felice, Antonio Galina, Rosalia Mendez-Otero, Sergio T. Ferreira
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-13 (2019)
Abstract Background Mesenchymal stem cells (MSCs) have been explored as promising tools for treatment of several neurological and neurodegenerative diseases. MSCs release abundant extracellular vesicles (EVs) containing a variety of biomolecules, inc
Externí odkaz:
https://doaj.org/article/6fd8843a30e946229814dae1d5a03890
Autor:
Claudia P. Figueiredo, Fernanda G. Q. Barros-Aragão, Rômulo L. S. Neris, Paula S. Frost, Carolina Soares, Isis N. O. Souza, Julianna D. Zeidler, Daniele C. Zamberlan, Virginia L. de Sousa, Amanda S. Souza, André Luis A. Guimarães, Maria Bellio, Jorge Marcondes de Souza, Soniza V. Alves-Leon, Gilda A. Neves, Heitor A. Paula-Neto, Newton G. Castro, Fernanda G. De Felice, Iranaia Assunção-Miranda, Julia R. Clarke, Andrea T. Da Poian, Sergio T. Ferreira
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Here, using ex-vivo human adult cortical tissue and a mouse model, the authors investigate the functional consequences of Zika virus (ZIKV) infection in the adult brain, and show that ZIKV causes synapse damage and altered brain function that impacts
Externí odkaz:
https://doaj.org/article/0bac999998154571acca058da9d921c8