Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Sergio Schenkman"'
Autor:
Veronica A. deLima, João P. S. Nunes, Daniela S. Rosa, Rodrigo Ferreira, Maria L. V. Oliva, Robert Andreata‐Santos, Marcia Duarte‐Barbosa, Luiz M. R. Janini, Juliana T. Maricato, Milena A. Akamatsu, Paulo L. Ho, Sergio Schenkman
Publikováno v:
Immunity, Inflammation and Disease, Vol 12, Iss 7, Pp n/a-n/a (2024)
Abstract Background SARS‐CoV2 virus, responsible for the COVID‐19 pandemic, has four structural proteins and 16 nonstructural proteins. S‐protein is one of the structural proteins exposed on the virus surface and is the main target for producin
Externí odkaz:
https://doaj.org/article/c5bf8a9eaf304fe0a2abdca12193c4c9
Autor:
Bijay Kumar Jha, Sanjay Varikuti, Chaitenya Verma, Rahul Shivahare, Nicholas Bishop, Gregory P. Dos Santos, Jacquelyn McDonald, Aakash Sur, Peter J. Myler, Sergio Schenkman, Abhay R. Satoskar, Bradford S. McGwire
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract Human infection with the protozoan parasite Trypanosoma cruzi causes Chagas disease for which there are no prophylactic vaccines. Cyclophilin 19 is a secreted cis-trans peptidyl isomerase expressed in all life stages of Trypanosoma cruzi. Th
Externí odkaz:
https://doaj.org/article/1367d015c44242d79c6a96b086f14752
Autor:
Carmen Fernandez‐Becerra, Patrícia Xander, Daniel Alfandari, George Dong, Iris Aparici‐Herraiz, Irit Rosenhek‐Goldian, Mehrdad Shokouhy, Melisa Gualdron‐Lopez, Nicholy Lozano, Nuria Cortes‐Serra, Paula Abou Karam, Paula Meneghetti, Rafael Pedro Madeira, Ziv Porat, Rodrigo Pedro Soares, Adriana Oliveira Costa, Sima Rafati, Anabela‐Cordeiro da Silva, Nuno Santarém, Christopher Fernandez‐Prada, Marcel I. Ramirez, Dolores Bernal, Antonio Marcilla, Vera Lucia Pereira‐Chioccola, Lysangela Ronalte Alves, Hernando Del Portillo, Neta Regev‐Rudzki, Igor Correia deAlmeida, Sergio Schenkman, Martin Olivier, Ana Claudia Torrecilhas
Publikováno v:
Journal of Extracellular Biology, Vol 2, Iss 10, Pp n/a-n/a (2023)
Abstract Parasites are responsible for the most neglected tropical diseases, affecting over a billion people worldwide (WHO, 2015) and accounting for billions of cases a year and responsible for several millions of deaths. Research on extracellular v
Externí odkaz:
https://doaj.org/article/abb07027d5734768a2837438788e98db
Autor:
Gabriela Venturini, Juliana M. Alvim, Kallyandra Padilha, Christopher N. Toepfer, Joshua M. Gorham, Lauren K. Wasson, Diogo Biagi, Sergio Schenkman, Valdemir M. Carvalho, Jessica S. Salgueiro, Karina H. M. Cardozo, Jose E. Krieger, Alexandre C. Pereira, Jonathan G. Seidman, Christine E. Seidman
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionChagas cardiomyopathy, a disease caused by Trypanosoma cruzi (T. cruzi) infection, is a major contributor to heart failure in Latin America. There are significant gaps in our understanding of the mechanism for infection of human cardiomyo
Externí odkaz:
https://doaj.org/article/dd5e4d9e31404b4a8296661ca7c6392c
Autor:
Gabriela de A. Burle-Caldas, Nailma S. A. dos Santos, Júlia T. de Castro, Fernanda L. B. Mugge, Viviane Grazielle-Silva, Antônio Edson R. Oliveira, Milton C. A. Pereira, João Luís Reis-Cunha, Anderson Coqueiro dos Santos, Dawidson Assis Gomes, Daniella C. Bartholomeu, Nilmar S. Moretti, Sergio Schenkman, Ricardo T. Gazzinelli, Santuza M. R. Teixeira
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Trans-sialidases (TS) are unusual enzymes present on the surface of Trypanosoma cruzi, the causative agent of Chagas disease. Encoded by the largest gene family in the T. cruzi genome, only few members of the TS family have catalytic activit
Externí odkaz:
https://doaj.org/article/726ccde2ca8642a08b521362024bc308
Autor:
Caio H. Franco, David C. Warhurst, Tapan Bhattacharyya, Ho Y.A. Au, Hai Le, Miriam A. Giardini, Bruno S. Pascoalino, Ana Claudia Torrecilhas, Lavinia M.D. Romera, Rafael Pedro Madeira, Sergio Schenkman, Lucio H. Freitas-Junior, Eric Chatelain, Michael A. Miles, Carolina B. Moraes
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss , Pp 107-120 (2020)
Ergosterol biosynthesis inhibitors, such as posaconazole and ravuconazole, have been proposed as drug candidates for Chagas disease, a neglected infectious tropical disease caused by the protozoan parasite Trypanosoma cruzi. To understand better the
Externí odkaz:
https://doaj.org/article/401d5796b83843e0ab37d5b3dcd25a14
Autor:
Leila dos Santos Moura, Vinícius Santana Nunes, Antoniel A. S. Gomes, Ana Caroline de Castro Nascimento Sousa, Marcos R. M. Fontes, Sergio Schenkman, Nilmar Silvio Moretti
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Trypanosoma cruzi faces a variety of environmental scenarios during its life cycle, which include changes in the redox environment that requires a fine regulation of a complex antioxidant arsenal of enzymes. Reversible posttranslational modifications
Externí odkaz:
https://doaj.org/article/b2184ffb836c407d84b96031dc53e401
Autor:
Camilla Ioshida Vasconcelos, A Cronemberger-Andrade, Normanda Souza-Melo, Juliana Terzi Maricato, Patrícia Xander, Wagner Luiz Batista, Rodrigo Pedro Soares, Sergio Schenkman, Ana Claudia Torrecilhas
Publikováno v:
Journal of Immunology Research, Vol 2021 (2021)
All extracellular forms of Trypanosoma cruzi, the causative agent of Chagas disease, release extracellular vesicles (EVs) containing major surface molecules of the parasite. EV release depends on several mechanisms (internal and external). However, m
Externí odkaz:
https://doaj.org/article/4ccb2f28e5df424aaafcb2d90d6471ae
Autor:
Ana Claudia Torrecilhas, Rodrigo Pedro Soares, Sergio Schenkman, Christopher Fernández-Prada, Martin Olivier
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Trypanosoma cruzi, Trypanosoma brucei and Leishmania (Trypanosomatidae: Kinetoplastida) are parasitic protozoan causing Chagas disease, African Trypanosomiasis and Leishmaniases worldwide. They are vector borne diseases transmitted by triatomine bugs
Externí odkaz:
https://doaj.org/article/4d53f234f9da414391178e350013f1b3
Autor:
Amaranta Muniz Malvezzi, Mirella Aricó, Normanda Souza-Melo, Gregory Pedroso dos Santos, Paula Bittencourt-Cunha, Fabiola Barbieri Holetz, Sergio Schenkman
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
The integrated stress response in eukaryotic cells is an orchestrated pathway that leads to eukaryotic Initiation Factor 2 alpha subunit (eIF2α) phosphorylation at ser51 and ultimately activates pathways to mitigate cellular damages. Three putative
Externí odkaz:
https://doaj.org/article/7ce7349a97ca49638898691d871db2fc