Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Sergio Portal-Núñez"'
Autor:
Daniel Lozano, Beatriz Leiva, Inés S. Gómez-Escalonilla, Sergio Portal-Núñez, Arancha R. de Górtazar, Miguel Manzano, María Vallet-Regí
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 658 (2023)
Osteoporosis is the most common type of bone disease. Conventional treatments are based on the use of antiresorptive drugs and/or anabolic agents. However, these treatments have certain limitations, such as a lack of bioavailability or toxicity in no
Externí odkaz:
https://doaj.org/article/167d482b994945b98106dd5484cb4f7c
Autor:
Lourdes Rodríguez-de la Rosa, Ana López-Herradón, Sergio Portal-Núñez, Silvia Murillo-Cuesta, Daniel Lozano, Rafael Cediel, Isabel Varela-Nieto, Pedro Esbrit
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87536 (2014)
Insulin-like growth factor-I (IGF-I) deficiency causes growth delay, and IGF-I has been shown to partially mediate bone anabolism by parathyroid hormone (PTH). PTH-related protein (PTHrP) is abundant in bone, and has osteogenic features by poorly def
Externí odkaz:
https://doaj.org/article/9ddb7445ec904869a6710041e68abcea
Autor:
Ana Lamuedra, Paula Gratal, Lucía Calatrava, Víctor Luis Ruiz‐Perez, Adrián Palencia‐Campos, Sergio Portal‐Núñez, Aránzazu Mediero, Gabriel Herrero‐Beaumont, Raquel Largo
Publikováno v:
The FASEB Journal. 36
Chondrocytes in osteoarthritic (OA) cartilage acquire a hypertrophic-like phenotype, where Hedgehog (Hh) signaling is pivotal. Hh overexpression causes OA-like cartilage lesions, whereas its downregulation prevents articular destruction in mouse mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a5bb316b5adc9aa5f6df2bd2060e38
https://doi.org/10.1096/fj.202101791rr
https://doi.org/10.1096/fj.202101791rr
Autor:
Ana Lamuedra, Gabriel Herrero-Beaumont, Adrian Palencia-Campos, Aránzazu Mediero, P. Gratal, Raquel Largo, Sergio Portal-Núñez, Lucía Calatrava, Victor L. Ruiz-Perez
BackgroundChondrocytes in osteoarthritic (OA) cartilage acquire a hypertrophic-like phenotype, where Hedgehog (Hh) signaling is pivotal. Hh overexpression causes OA-like cartilage lesions, whereas its downregulation prevents articular destruction in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a49231a016a6605aa995ed6e4ec0fe84
https://doi.org/10.1101/2021.10.29.466392
https://doi.org/10.1101/2021.10.29.466392
Autor:
Óscar Lorenzo, Jesús Egido, Antonio Martín-Duce, Robert T. Jensen, Samuel A. Mantey, Raúl Sanz, Zaida Moreno-Villegas, Nieves González, César Aparicio, Sergio Portal-Núñez
Publikováno v:
Molecular and Cellular Endocrinology. 474:10-19
BRS-3 has an important role in glucose homeostasis. Its expression was reduced in skeletal muscle from obese and/or diabetic patients, and BRS-3 KO-mice developed obesity. In this work, focused on rat/human adipose tissue, BRS-3 gene-expression was l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57c32dc63841c95988ac59002ba0fc6d
https://doi.org/10.1016/j.mce.2018.01.028
https://doi.org/10.1016/j.mce.2018.01.028
Autor:
Marta Martínez-Pérez, C. Pérez-Jorge, Enrique Gómez-Barrena, Sergio Portal-Núñez, J.M. Hernández-López, Daniel Lozano, P. Esbrit, Ramón Pérez-Tanoira, J. de Damborenea, A. Conde, M. A. Arenas, Jaime Esteban
Publikováno v:
Bone & Joint Research. 6:315-322
Objectives Implant-related infection is one of the most devastating complications in orthopaedic surgery. Many surface and/or material modifications have been developed in order to minimise this problem; however, most of the in vitro studies did not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1893b67564d6a50afecc73cb0065f37f
https://doi.org/10.1302/2046-3758.65.bjr-2016-0226.r2
https://doi.org/10.1302/2046-3758.65.bjr-2016-0226.r2
Publikováno v:
Trends in endocrinology and metabolism: TEM. 30(10)
Musculoskeletal disorders represent an elevated socioeconomic burden for developed aging societies. Osteoporosis (OP) has been treated with antiresorptive therapies or with teriparatide that was until recently the only anabolic therapy. However, appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec58105a7ae07cba8f5ff55d674ab483
https://pubmed.ncbi.nlm.nih.gov/31409530
https://pubmed.ncbi.nlm.nih.gov/31409530
Autor:
Irene Martínez de Toda, Juan A. Ardura, Irantzu Castelbón-Calvo, Pedro Esbrit, Sergio Portal-Núñez, Mónica De la Fuente
Publikováno v:
Journal of Cellular Physiology. 232:785-796
Oxidative damage is an important contributor to the morphological and functional changes in osteoporotic bone. Aging increases the levels of reactive oxygen species (ROS) that cause oxidative stress and induce osteoblast apoptosis. ROS modify several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2887d6997bcf9eded8184a6a6b54b0c7
https://doi.org/10.1002/jcp.25473
https://doi.org/10.1002/jcp.25473
Publikováno v:
Biochemical Pharmacology. 108:1-10
Aging is a natural process characterized by the declining ability of the different organs and tissues to respond to stress, increasing homeostatic imbalance and risk of disease. Osteoarthritis (OA) is a multifactorial disease in which cartilage degra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7772c82fbd4f45f6c380c4bfac9cea
https://doi.org/10.1016/j.bcp.2015.12.012
https://doi.org/10.1016/j.bcp.2015.12.012
Autor:
M. De la Fuente, Sergio Portal-Núñez, I. Martínez de Toda, Gabriel Herrero-Beaumont, Daniel Lozano, Raquel Largo, P. Esbrit, Juan A. Ardura
Publikováno v:
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Bone & Joint Research
instname
Bone & Joint Research
Objectives: Oxidative stress plays a major role in the onset and progression of involutional osteoporosis. However, classical antioxidants fail to restore osteoblast function. Interestingly, the bone anabolism of parathyroid hormone (PTH) has been sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2088bbc8a0d5d51c63cd483d9888304c
https://hdl.handle.net/10486/681580
https://hdl.handle.net/10486/681580