Výsledky vyhledávání - "Sergio Pedraza Arevalo"

Akademický článek

Spliceosomic dysregulation in pancreatic cancer uncovers splicing factors PRPF8 and RBMX as novel candidate actionable targets

Publikováno v: Molecular Oncology, Vol 18, Iss 10, Pp 2524-2540 (2024)

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, characterized by late diagnosis and poor treatment response. Surgery is the only curative approach, only available to early‐diagnosed patients. Current therapies have limited effect

Externí odkaz: https://doaj.org/article/de947d6fca6d49f9911a2528b10949ca

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Akademický článek

Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery

Autor: Ricardo Blázquez-Encinas, Víctor García-Vioque, Teresa Caro-Cuenca, María Trinidad Moreno-Montilla, Federica Mangili, Emilia Alors-Pérez, Sebastian Ventura, Aura D. Herrera-Martínez, Paula Moreno-Casado, Marco A. Calzado, Ángel Salvatierra, María A. Gálvez-Moreno, Lynnette Fernandez-Cuesta, Matthieu Foll, Raúl M. Luque, Nicolas Alcala, Sergio Pedraza-Arevalo, Alejandro Ibáñez-Costa, Justo P. Castaño

Publikováno v: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)

Abstract Background Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of tumors ranging from indolent lesions with good prognosis to highly aggressive cancers. Carcinoids are the rarest LungNENs, display low to intermediate mali

Externí odkaz: https://doaj.org/article/d52791785b0348c3acabc1dd11422717

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Akademický článek

Altered CELF4 splicing factor enhances pancreatic neuroendocrine tumors aggressiveness influencing mTOR and everolimus response

Autor: Emilia Alors-Pérez, Sergio Pedraza-Arevalo, Ricardo Blázquez-Encinas, Víctor García-Vioque, Antonio Agraz-Doblas, Elena M. Yubero-Serrano, Marina E. Sánchez-Frías, Raquel Serrano-Blanch, María Ángeles Gálvez-Moreno, Francisco Gracia-Navarro, Manuel D. Gahete, Álvaro Arjona-Sánchez, Raúl M. Luque, Alejandro Ibáñez-Costa, Justo P. Castaño

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102090- (2024)

Pancreatic neuroendocrine tumors (PanNETs) comprise a heterogeneous group of tumors with growing incidence. Recent molecular analyses provided a precise picture of their genomic and epigenomic landscape. Splicing dysregulation is increasingly regarde

Externí odkaz: https://doaj.org/article/46b3eb5e3ec743c68155cde95dd29e80

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Akademický článek

Splicing alterations in pancreatic ductal adenocarcinoma: a new molecular landscape with translational potential

Autor: Emilia Alors-Pérez, Sergio Pedraza-Arevalo, Ricardo Blázquez-Encinas, María Trinidad Moreno-Montilla, Víctor García-Vioque, Inmaculada Berbel, Raúl M. Luque, Bruno Sainz, Alejandro Ibáñez-Costa, Justo P. Castaño

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)

Abstract Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers worldwide, mainly due to its late diagnosis and lack of effective therapies, translating into a low 5-year 12% survival rate, despite extensive clinical efforts t

Externí odkaz: https://doaj.org/article/a84214f7f90144bfaa84a7594e4529bf

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Akademický článek

Epigenetic and post‐transcriptional regulation of somatostatin receptor subtype 5 (SST5) in pituitary and pancreatic neuroendocrine tumors

Autor: Sergio Pedraza‐Arevalo, Alejandro Ibáñez‐Costa, Ricardo Blázquez‐Encinas, Miguel R. Branco, Mari C. Vázquez‐Borrego, Aura D. Herrera‐Martínez, Eva Venegas‐Moreno, Raquel Serrano‐Blanch, Álvaro Arjona‐Sánchez, María A. Gálvez‐Moreno, Marta Korbonits, Alfonso Soto‐Moreno, Manuel D. Gahete, Marika Charalambous, Raúl M. Luque, Justo P. Castaño

Publikováno v: Molecular Oncology, Vol 16, Iss 3, Pp 764-779 (2022)

Somatostatin receptor subtype 5 (SST5) is an emerging biomarker and actionable target in pituitary (PitNETs) and pancreatic (PanNETs) neuroendocrine tumors. Transcriptional and epigenetic regulation of SSTR5 gene expression and mRNA biogenesis is poo

Externí odkaz: https://doaj.org/article/b32f6c1bca5844c5a89dc0ab9f39ab12

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Akademický článek

Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-21 (2021)

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring novel treatments to target both cancer cells and cancer stem cells (CSCs). Altered splicing is emerging as both a novel cancer hallmark and an attractive

Externí odkaz: https://doaj.org/article/2e57a0d7fd7f42d6a9f88e1c0cae6aca

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Akademický článek

Differentiation of beta-like cells from human induced pluripotent stem cell-derived pancreatic progenitor organoids

Autor: Sergio Pedraza-Arevalo, Ana-Maria Cujba, Mario Enrique Alvarez-Fallas, Rocio Sancho

Publikováno v: STAR Protocols, Vol 3, Iss 3, Pp 101656- (2022)

Summary: Human induced pluripotent stem cells (hiPSCs) and organoids are important for modeling human development and disease in vitro. In this study, we describe a protocol to differentiate hiPSC toward pancreatic progenitor (PP) organoids and beta-

Externí odkaz: https://doaj.org/article/6e78da5a9a6242bfaa92ef7748d07f91

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