Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sergio Mares"'
Autor:
Biraj B. Kayastha, Aya Kubo, Jacob Burch-Konda, Rosalie L. Dohmen, Jacee L. McCoy, Rendi R. Rogers, Sergio Mares, Justin Bevere, Annalisa Huckaby, William Witt, Shuxia Peng, Bharat Chaudhary, Smita Mohanty, Mariette Barbier, Gabriel Cook, Junpeng Deng, Marianna A. Patrauchan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Calcium (Ca2+) is well known as a second messenger in eukaryotes, where Ca2+ signaling controls life-sustaining cellular processes. Although bacteria produce the components required for Ca2+ signaling, little is known about the mechanisms of
Externí odkaz:
https://doaj.org/article/25b2537cac2b4b44875de3dcda394a67
Autor:
Linda Campos‐Fernández, Rocío Ortiz‐Muñiz, Edith Cortés‐Barberena, Sergio Mares‐Sámano, Ramón Garduño‐Juárez, Catalina Soriano‐Correa
Publikováno v:
Journal of Computational Chemistry. 43:1573-1595
Chagas disease is caused by Trypanosoma cruzi. Benznidazole and nifurtimox are drugs used for its therapy; nevertheless, they have collateral effects. NADH-fumarate (FUM) reductase is a potential pharmacological target since it is essential for survi
Publikováno v:
Journal of biomolecular structuredynamics.
Discrepin is a 38-residue α-toxin extracted from the venom of the Venezuelan scorpion Tityus discrepans, which inhibits ionic transit in the voltage-dependent potassium channels (Kv) of A-type current. The effect of specific residues on the IC50 bet
Publikováno v:
Journal of Chemical Information and Modeling. 61:2328-2340
Inhibition of the expression of the human ether-a-go-go (hEAG1 or hKV10.1) channel is associated with a dramatic reduction in the growth of several cancerous tumors. The modulation of this channel’...
Publikováno v:
Computación y Sistemas. 23
Unprecedented advancements have been achieved to understand the underlying mechanisms that sustain life. The modulation of these mechanisms, especially in disease conditions, could lead to the development of new medical applications. However, to atta
Publikováno v:
Computación y Sistemas. 22
Human serum albumin (HSA) is the most abundant protein in the circulatory system that shows a remarkable capacity to bind a wide range of drugs impacting their therapeutic effect. Therefore, the binding to HSA represents a fundamental factor to consi
Publikováno v:
Bioinformation
ABCC1 is a member of the ATP-binding Cassette super family of transporters, actively effluxes xenobiotics from cells. Clinically, ABCC1 expression is linked to cancer multidrug resistance. Substrate efflux is energised by ATP binding and hydrolysis a
Publikováno v:
Basic Toxicology. 97:122-124
With a mexican diet we have found that after a single oral dose of 800 mg of albendazole, maximum plasma levels and the area under the plasma concentration curve increased seven and eight times respectively, however the elimination rate was not alter
Publikováno v:
European journal of medicinal chemistry. 44(9)
Homology modelling was used to generate three-dimensional structures of the nucleotide-binding domains (NBDs) of human ABCB1 and ABCG2. Interactions between a series of steroidal ligands and transporter NBDs were investigated using an in silico docki