Extraction, purification and biochemical characterization of a peroxidase from Copaifera langsdorffii leaves

Autor: Hermelinda Penha Freire Maciel, Cibele Marli Cação Paiva Gouvêa, Marcos Toyama, Marcus Smolka, Sergio Marangoni, Gláucia Maria Pastore

Publikováno v: Química Nova, Vol 30, Iss 5, Pp 1067-1071 (2007)

The aim of this work is to obtain, purify and characterize biochemically a peroxidase from Copaifera langsdorffii leaves (COP). COP was obtained by acetone precipitation followed by ion-exchange chromatography. Purification yielded 3.5% of peroxidase

Externí odkaz: https://doaj.org/article/744b66e0613f4e4b8753329f57718743

Structural, enzymatic and pharmacological profiles of AplTX-II - A basic sPLA2 (D49) isolated from the Agkistrodon piscivorus leucostoma snake venom

Autor: L.M. Resende, Andreimar Martins Soares, Pedro A. Fernandes, Sergio Marangoni, Saulo L. da Silva, José R. Almeida, Tatiana A. Guaraca-Medina, Matilde F. Viegas, Maria J. Ramos

Publikováno v: International Journal of Biological Macromolecules. 175:572-585

A basic sPLA2 (D49) from the venom of snake Agkistrodon piscivorus leucostoma (AplTX-II) was isolated, purified and characterized. We determined the enzymatic and pharmacological profiles of this toxin. AplTX-II was isolated with a high level of puri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88d17e5fcba9765f15dbddb273622ac5
https://doi.org/10.1016/j.ijbiomac.2021.01.187

Snake Venom Extracellular vesicles (SVEVs) reveal wide molecular and functional proteome diversity

Autor: Sergio Marangoni, Paulo A. Baldasso, Martin R. Larsen, Victor Corassolla Carregari, Sérgio Paulo Bydlowski, Livia Rosa-Fernandes, Giuseppe Palmisano

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports
Carregari, V C, Rosa-Fernandes, L, Baldasso, P, Bydlowski, S P, Marangoni, S, Larsen, M R & Palmisano, G 2018, ' Snake Venom Extracellular vesicles (SVEVs) reveal wide molecular and functional proteome diversity ', Scientific Reports, vol. 8, no. 1, 12067, pp. 1-16 . https://doi.org/10.1038/s41598-018-30578-4
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Proteins constitute almost 95% of snake venom’s dry weight and are produced and released by venom glands in a solubilized form during a snake bite. These proteins are responsible for inducing several pharmacological effects aiming to immobilize and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca4a4abffb1e5277ec7d59a880cecfb
http://link.springer.com/article/10.1038/s41598-018-30578-4

Exploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A2, AplTx-I, purified from Agkistrodon piscivorus leucostoma snake venom

Autor: Leonardo A. Calderon, Lea Rodrigues Simioni, S. L. Da Silva, Sergio Marangoni, Raphael Schezaro-Ramos, L.M. Resende, Andreimar M. Soares, David Ramírez, R.C.O. Collaço, Wendy González, José R. Almeida

Publikováno v: Toxicon. 127:22-36

Phospholipases A 2 (PLA 2 s) constitute a class of extensively studied toxins, isolated from snake venoms. Basic PLA 2 isoforms mediate various toxicological effects, while the acidic isoforms generally have higher enzymatic activities, but do not pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef9ba233ead31f3c2ff1784242a353fa
https://doi.org/10.1016/j.toxicon.2017.01.002

Anticarcinogenic potential of BbTX-II on large lung cell carcinoma (NCI-H460)

Autor: Sergio Marangoni, Luciana Maria de Hollanda, Edda Evnet Newball-Noriega, Salomón Huancahuire-Vega

Publikováno v: Toxicon. 177:S48

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::425c174436f499e4709ccecd1451b944
https://doi.org/10.1016/j.toxicon.2019.12.098