Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sergio M. Pontejo"'
Autor:
Caroline Andrews, Mairi H. McLean, Julie A. Hixon, Sergio M. Pontejo, Tregei Starr, Courtney Malo, Margaret Cam, Lisa Ridnour, Heather Hickman, Olivia Steele-Mortimer, David A. Wink, Howard A. Young, Daniel W. McVicar, Wenqing Li, Scott K. Durum
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mucosal delivery of IL-27 has been shown to have a therapeutic benefit in murine models of inflammatory bowel disease (IBD). The IL-27 effect was associated with phosphorylated STAT1 (pSTAT1), a product of IL27 receptor signaling, in bowel tissue. To
Externí odkaz:
https://doaj.org/article/63471c5b8e93457bbc461734fa452b98
Autor:
Sergio M. Pontejo, Philip M. Murphy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/b2752b0426ec47cca002bf7eb34246ef
Autor:
Alí Alejo, M. Begoña Ruiz-Argüello, Sergio M. Pontejo, María del Mar Fernández de Marco, Margarida Saraiva, Bruno Hernáez, Antonio Alcamí
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Cytokines play critical roles in the anti-viral response but their contribution in vivo remains unclear. Here the authors show that viral CrmD is a major virulence determinant and requires the SECRET and TNF binding domains to counter both the chemok
Externí odkaz:
https://doaj.org/article/0f471da0fe0f47cfb7468c4516c8b948
Autor:
Shamik Majumdar, Sergio M. Pontejo, Hemant Jaiswal, Ji-Liang Gao, Abigail Salancy, Elizabeth Stassenko, Hidehiro Yamane, David H. McDermott, Karl Balabanian, Françoise Bachelerie, Philip M. Murphy
Publikováno v:
The Journal of Immunology.
Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is an ultra-rare combined primary immunodeficiency disease caused by heterozygous gain-of-function mutations in the chemokine receptor CXCR4. WHIM patients typically present
Autor:
Shamik Majumdar, Ji-Liang Gao, Sergio M. Pontejo, Karl Balabanian, Françoise Bachelerie, Philip M. Murphy
Publikováno v:
ImmunoHorizons. 6(7)
Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome immunodeficiency is caused by autosomal dominant gain-of-function CXCR4 mutations that promote severe panleukopenia caused by bone marrow retention of mature leukocytes. Cons
Autor:
Nicolas Çuburu, Lukasz Bialkowski, Sergio M. Pontejo, Shiv K. Sethi, Alexander T. F. Bell, Rina Kim, Cynthia D. Thompson, Douglas R. Lowy, John T. Schiller
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(26)
Tumor infiltration by T cells profoundly affects cancer progression and responses to immunotherapy. However, the tumor immunosuppressive microenvironment can impair the induction, trafficking, and local activity of antitumor T cells. Here, we investi
Autor:
Heather D. Hickman, Chyi-Chia Richard Lee, Peter Olbrich, Jean K. Lim, Daniel Chauss, Vasileios Oikonomou, Daniel L. Barber, Philip M. Murphy, Monica M. Schmitt, Tilo Freiwald, Marc Swidergall, Stefania Pittaluga, Steven M. Holland, Daniel Martin, Luigi D. Notarangelo, Oliver J. Harrison, Scott G. Filler, Lindsey B. Rosen, Ian A. Myles, Wint Lwin, Sergio M. Pontejo, Behdad Afzali, Timothy J. Break, Niki M. Moutsopoulos, Vincent M. Bruno, Julie Alejo, Jigar V. Desai, Nicolas Bouladoux, Elise M. N. Ferré, Norma V. Solis, Mitsuru Matsumoto, David V. Serreze, Yasmine Belkaid, Andy Renteria, John P. Shannon, Nicolas Dutzan, Teresa Greenwell-Wild, Michail S. Lionakis, Drake W. Williams, Kevin W. Hoffman, Muthulekha Swamydas, Mark S. Anderson
Publikováno v:
Science
Puel and Casanova and Kisand et al . challenge our conclusions that interferonopathy and not IL-17/IL-22 autoantibodies promote candidiasis in autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy. We acknowledge that conclusive evidence
Autor:
Philip M. Murphy, Sergio M. Pontejo
Publikováno v:
PLoS Biology, Vol 19, Iss 5, p e3001259 (2021)
PLoS Biology
PLoS Biology
Removal of apoptotic cells is essential for maintenance of tissue homeostasis. Chemotactic cues termed “find-me” signals attract phagocytes toward apoptotic cells, which selectively expose the anionic phospholipid phosphatidylserine (PS) and othe
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Etanercept is a soluble form of the tumor necrosis factor receptor 2 (TNFR2) that inhibits pathological tumor necrosis factor (TNF) responses in rheumatoid arthritis and other inflammatory diseases. However, besides TNF, etanercept also blocks lympho
Autor:
Julie Alejo, Jigar V. Desai, Ian A. Myles, Niki M. Moutsopoulos, Peter Olbrich, Michail S. Lionakis, Vasileios Oikonomou, Philip M. Murphy, Norma V. Solis, Tilo Freiwald, Scott G. Filler, Heather D. Hickman, Steven M. Holland, Stefania Pittaluga, Sergio M. Pontejo, Teresa Greenwell-Wild, Marc Swidergall, Lindsey B. Rosen, Kevin W. Hoffman, Mark S. Anderson, Timothy J. Break, Vincent M. Bruno, Daniel Chauss, Wint Lwin, Muthulekha Swamydas, Behdad Afzali, Chyi-Chia Richard Lee, David V. Serreze, Daniel Martin, Oliver J. Harrison, Yasmine Belkaid, Jean K. Lim, Andy Renteria, John P. Shannon, Nicolas Dutzan, Monica M. Schmitt, Daniel L. Barber, Luigi D. Notarangelo, Drake W. Williams, Elise M. N. Ferré, Mitsuru Matsumoto, Nicolas Bouladoux
Publikováno v:
Science
Science (New York, N.Y.), vol 371, iss 6526
Science (New York, N.Y.), vol 371, iss 6526
INTRODUCTION: Studies of monogenic diseases have uncovered the importance of immune pathways in human tissue-specific immunity and antimicrobial defense. In particular, human inborn errors of the interleukin-17 (IL-17) receptor signaling pathway and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9858aefc910c2c232d75d169c1c48067
https://hdl.handle.net/11391/1537575
https://hdl.handle.net/11391/1537575