Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Sergio Lociuro"'
Autor:
Vincent Trebosc, Valentina Lucchini, Mohit Narwal, Basil Wicki, Sarah Gartenmann, Birgit Schellhorn, Julian Schill, Marilyne Bourotte, Daniel Frey, Jürgen Grünberg, Andrej Trauner, Livia Ferrari, Antonio Felici, Olivia L. Champion, Marc Gitzinger, Sergio Lociuro, Richard A. Kammerer, Christian Kemmer, Michel Pieren
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 1868-1883 (2022)
The development of anti-virulence drug therapy against Acinetobacter baumannii infections would provide an alternative to traditional antibacterial therapy that are increasingly failing. Here, we demonstrate that the OmpR transcriptional regulator pl
Externí odkaz:
https://doaj.org/article/15918578828b477baf8ad5a55dd06209
Autor:
Alysha G. Elliott, Johnny X. Huang, Søren Neve, Johannes Zuegg, Ingrid A. Edwards, Amy K. Cain, Christine J. Boinett, Lars Barquist, Carina Vingsbo Lundberg, Jason Steen, Mark S. Butler, Mehdi Mobli, Kaela M. Porter, Mark A. T. Blaskovich, Sergio Lociuro, Magnus Strandh, Matthew A. Cooper
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Peptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negativ
Externí odkaz:
https://doaj.org/article/c52da634b87d440cbbc0c10a3c254c56
Autor:
Valentina Lucchini, Adeline Sivignon, Michel Pieren, Marc Gitzinger, Sergio Lociuro, Nicolas Barnich, Christian Kemmer, Vincent Trebosc
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Gut microbiota dysbiosis toward adherent-invasive Escherichia coli (AIEC) plays an important role in Crohn’s disease (CD). The OmpR transcriptional regulator is required for the AIEC LF82 prototype strain to adhere and invade intestinal epithelial
Externí odkaz:
https://doaj.org/article/03e663cc3e85469bb13c1b7603dad794
Autor:
Vincent Trebosc, Sarah Gartenmann, Marcus Tötzl, Valentina Lucchini, Birgit Schellhorn, Michel Pieren, Sergio Lociuro, Marc Gitzinger, Marcel Tigges, Dirk Bumann, Christian Kemmer
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Nosocomial infections with Acinetobacter baumannii are a global problem in intensive care units with high mortality rates. Increasing resistance to first- and second-line antibiotics has forced the use of colistin as last-resort treatment, a
Externí odkaz:
https://doaj.org/article/91810f005a4447e3bedcd876f3281f97
Autor:
Alexander Lederer, John A. Robinson, Kerstin Moehle, Thomas Klimkait, François Hamy, Vincent Brondani, Sergio Lociuro, Jean-Pierre Obrecht, Jan Willem Vrijbloed, Christian Ludin, Frank O. Gombert, Federico Brianza, Jürg Zumbrunn, Reshmi Mukherjee, Barbara Romagnoli, Heiko Henze, Steven J. DeMarco, Daniel Obrecht
Publikováno v:
CHIMIA, Vol 61, Iss 4 (2007)
Novel, highly potent CXCR4 inhibitors with good pharmacokinetic properties were obtained by applying PEM technology starting from the naturally occurring ?-hairpin peptide polyphemusin II. The design involved incorporation of key residues from polyph
Externí odkaz:
https://doaj.org/article/8217e99491f84874af190a472277fb21
Autor:
Marion Flipo, Rosangela Frita, Marilyne Bourotte, María S. Martínez-Martínez, Markus Boesche, Gary W. Boyle, Geo Derimanov, Gerard Drewes, Pablo Gamallo, Sonja Ghidelli-Disse, Stephanie Gresham, Elena Jiménez, Jaime de Mercado, Esther Pérez-Herrán, Esther Porras-De Francisco, Joaquín Rullas, Patricia Casado, Florence Leroux, Catherine Piveteau, Mehdi Kiass, Vanessa Mathys, Karine Soetaert, Véronique Megalizzi, Abdalkarim Tanina, René Wintjens, Rudy Antoine, Priscille Brodin, Vincent Delorme, Martin Moune, Kamel Djaout, Stéphanie Slupek, Christian Kemmer, Marc Gitzinger, Lluis Ballell, Alfonso Mendoza-Losana, Sergio Lociuro, Benoit Deprez, David Barros-Aguirre, Modesto J. Remuiñán, Nicolas Willand, Alain R. Baulard
Publikováno v:
Science Translational Medicine. 14
The sensitivity of Mycobacterium tuberculosis , the pathogen that causes tuberculosis (TB), to antibiotic prodrugs is dependent on the efficacy of the activation process that transforms the prodrugs into their active antibacterial moieties. Various o
Publikováno v:
Drug discovery today. 26(9)
Rifamycin antibiotics were discovered during the 1950s, and their main representative, rifampicin, remains a cornerstone treatment for TB. The clinical use of rifamycin is restricted to mycobacteria and Gram-positive infections because of its poor ab
Autor:
Mark E. Cooper, Alysha G. Elliott, Amy K. Cain, Ingrid A. Edwards, Mehdi Mobli, Carina Vingsbo Lundberg, Johnny X. Huang, Sergio Lociuro, Søren Neve, Magnus Strandh, Mark A. T. Blaskovich, Jason A. Steen, Kaela M. Porter, Mark S. Butler, Lars Barquist, Christine J. Boinett, Johannes Zuegg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature communications
United Kingdom
England
Nature Communications
Nature communications
United Kingdom
England
Peptide antibiotics are an abundant and synthetically tractable source of molecular diversity, but they are often cationic and can be cytotoxic, nephrotoxic and/or ototoxic, which has limited their clinical development. Here we report structure-guide
Autor:
Marcel Tigges, Birgit Schellhorn, Marc Gitzinger, Sarah Gartenmann, Vincent Trebosc, Marcus Tötzl, Michel Pieren, Dirk Bumann, Christian Kemmer, Valentina Lucchini, Sergio Lociuro
Publikováno v:
mBio, Vol 10, Iss 4, p e01083-19 (2019)
mBio
mBio, Vol 10, Iss 4 (2019)
mBio
mBio, Vol 10, Iss 4 (2019)
The discovery of antibiotics revolutionized modern medicine and enabled us to cure previously deadly bacterial infections. However, a progressive increase in antibiotic resistance rates is a major and global threat for our health care system. Colisti
Autor:
Daniele Donati, Stefano Biondi, Alfredo Paio, Stjepan Mutak, Sergio Lociuro, Elisa Piga, Francesca Cardullo, Dražen Pavlović, Daniele Andreotti
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1133-1137
An efficient synthesis of α-amino-γ-lactone ketolide (3) was developed, which provided a versatile intermediate for the incorporation of a variety of aryl and heteroaryl groups onto the C-21 position of clarithromycin via HBTU-mediated amidation. T