Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Sergio Lilla"'
Autor:
Christian Marx, Jürgen Sonnemann, Mandy Beyer, Oliver D. K. Maddocks, Sergio Lilla, Irene Hauzenberger, Andrea Piée‐Staffa, Kanstantsin Siniuk, Suneetha Nunna, Lisa Marx‐Blümel, Martin Westermann, Tobias Wagner, Felix B. Meyer, René Thierbach, Christina S. Mullins, Said Kdimati, Michael Linnebacher, Francesco Neri, Thorsten Heinzel, Zhao‐Qi Wang, Oliver H. Krämer
Publikováno v:
Molecular Oncology, Vol 15, Iss 12, Pp 3404-3429 (2021)
Late‐stage colorectal cancer (CRC) is still a clinically challenging problem. The activity of the tumor suppressor p53 is regulated via post‐translational modifications (PTMs). While the relevance of p53 C‐terminal acetylation for transcription
Externí odkaz:
https://doaj.org/article/0b74c48fb69942fab1d217753fe500f2
Autor:
Sergi Marco, Matthew Neilson, Madeleine Moore, Arantxa Perez-Garcia, Holly Hall, Louise Mitchell, Sergio Lilla, Giovani R. Blanco, Ann Hedley, Sara Zanivan, Jim C. Norman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Effective delivery of signals from the cell surface to the nucleus is a key to activate gene transcription. Here, the authors show how endosomes containing EphA2 are transported and captured at the nuclear surface, triggering depletion of G-actin fro
Externí odkaz:
https://doaj.org/article/5026a0dde67b478d8be77b8ddb4c8629
Autor:
David J. McGarry, Giovanni Castino, Sergio Lilla, Alexandre Carnet, Loughlin Kelly, Katarina Micovic, Sara Zanivan, Michael F. Olson
Publikováno v:
Cell Reports, Vol 41, Iss 1, Pp 111442- (2022)
Summary: The MICAL1 monooxygenase is an important regulator of filamentous actin (F-actin) structures. Although MICAL1 has been shown to be regulated via protein-protein interactions at the autoinhibitory carboxyl terminus, a link between actin-regul
Externí odkaz:
https://doaj.org/article/0dc737e63c4e447d911c2e48fde6180a
Autor:
Elisa Närvä, Maria E. Taskinen, Sergio Lilla, Aleksi Isomursu, Mika Pietilä, Jere Weltner, Jorma Isola, Harri Sihto, Heikki Joensuu, Sara Zanivan, Jim Norman, Johanna Ivaska
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104459- (2022)
Summary: MASTL is a mitotic accelerator with an emerging role in breast cancer progression. However, the mechanisms behind its oncogenicity remain largely unknown. Here, we identify a previously unknown role and eminent expression of MASTL in stem ce
Externí odkaz:
https://doaj.org/article/49fc6d2d2b354fafb82f10b872696eca
Autor:
Marisa Nacke, Emma Sandilands, Konstantina Nikolatou, Álvaro Román-Fernández, Susan Mason, Rachana Patel, Sergio Lilla, Tamas Yelland, Laura C. A. Galbraith, Eva C. Freckmann, Lynn McGarry, Jennifer P. Morton, Emma Shanks, Hing Y. Leung, Elke Markert, Shehab Ismail, Sara Zanivan, Karen Blyth, David M. Bryant
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
The signalling pathways underpinning cell growth and invasion use overlapping components, yet how mutually exclusive responses occur is unclear. Here, the authors show that alternate isoforms of the ARF GTPase exchange factor IQSEC1 direct phosphoino
Externí odkaz:
https://doaj.org/article/5313ed90f36c4817a2437ea2428b588c
Autor:
Mark J. Salji, Arnaud Blomme, J. Henry M. Däbritz, Peter Repiscak, Sergio Lilla, Rachana Patel, David Sumpton, Niels J.F. van den Broek, Ronan Daly, Sara Zanivan, Hing Y. Leung
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104056- (2022)
Summary: Castration-resistant prostate cancer (CRPC) is incurable and remains a significant worldwide challenge (Oakes and Papa, 2015). Matched untargeted multi-level omic datasets may reveal biological changes driving CRPC, identifying novel biomark
Externí odkaz:
https://doaj.org/article/3805fc748f104f7ba51eabf9fb2117d5
Autor:
Arnaud Blomme, Coralie Peter, Ernest Mui, Giovanny Rodriguez Blanco, Ning An, Louise M Mason, Lauren E Jamieson, Grace H McGregor, Sergio Lilla, Chara Ntala, Rachana Patel, Marc Thiry, Sonia H Y Kung, Marine Leclercq, Catriona A Ford, Linda K Rushworth, David J McGarry, Susan Mason, Peter Repiscak, Colin Nixon, Mark J Salji, Elke Markert, Gillian M MacKay, Jurre J Kamphorst, Duncan Graham, Karen Faulds, Ladan Fazli, Martin E Gleave, Edward Avezov, Joanne Edwards, Huabing Yin, David Sumpton, Karen Blyth, Pierre Close, Daniel J Murphy, Sara Zanivan, Hing Y Leung
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 3, Pp n/a-n/a (2022)
Abstract Despite the clinical benefit of androgen‐deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal castration‐resistant prostate cancer (CRPC). In this study, we identified thioeste
Externí odkaz:
https://doaj.org/article/0b32d6de175042e18b789240104f3924
Autor:
Arnaud Blomme, Catriona A. Ford, Ernest Mui, Rachana Patel, Chara Ntala, Lauren E. Jamieson, Mélanie Planque, Grace H. McGregor, Paul Peixoto, Eric Hervouet, Colin Nixon, Mark Salji, Luke Gaughan, Elke Markert, Peter Repiscak, David Sumpton, Giovanny Rodriguez Blanco, Sergio Lilla, Jurre J. Kamphorst, Duncan Graham, Karen Faulds, Gillian M. MacKay, Sarah-Maria Fendt, Sara Zanivan, Hing Y. Leung
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Androgen receptor (AR) signalling regulates cellular metabolism in prostate cancer. Here, the authors perform a proteomics and metabolomics characterisation of prostate cancer cells adapted to long-term resistance to AR inhibition and show rewiring o
Externí odkaz:
https://doaj.org/article/2a468699bc1a4fa682a39a1ff7c055bc
Publikováno v:
Communicative & Integrative Biology, Vol 12, Iss 1, Pp 112-118 (2019)
Fam49 proteins, now referred to as CYRI (CYFIP-related Rac Interactor), are evolutionarily conserved across many phyla. Their closest relative by amino acid sequence is CYFIP, as both proteins contain a domain of unknown function DUF1394. We recently
Externí odkaz:
https://doaj.org/article/4e335c0280cb4f61b8e27df60a3e402a
Autor:
Shashi Prakash Singh, Peter A Thomason, Sergio Lilla, Matthias Schaks, Qing Tang, Bruce L Goode, Laura M Machesky, Klemens Rottner, Robert H Insall
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000774 (2020)
The Scar/WAVE complex is the principal catalyst of pseudopod and lamellipod formation. Here we show that Scar/WAVE's proline-rich domain is polyphosphorylated after the complex is activated. Blocking Scar/WAVE activation stops phosphorylation in both
Externí odkaz:
https://doaj.org/article/bdfc9a7e62504de482bc8b2512da123b