Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors

Autor: Clément Anfray, Carmen Fernández Varela, Aldo Ummarino, Akihiro Maeda, Marina Sironi, Sara Gandoy, Jose Brea, María Isabel Loza, Sergio León, Alfonso Calvo, Juan Correa, Eduardo Fernandez-Megia, María José Alonso, Paola Allavena, José Crecente-Campo, Fernando Torres Andón

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

BackgroundIn the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod (R8

Externí odkaz: https://doaj.org/article/6cca62f205fd47608a66754ddd717c91

Experiencia en colectas de sangre móviles en una comunidad estudiantil universitaria Experience on mobile blood collection in university student

Autor: Marcela Vásquez Rojas, Sergio León González, Mónica Maldonado Rojas, Carla Toro Opazo

Publikováno v: Revista Cubana de Hematología, Inmunología y Hemoterapia, Vol 25, Iss 3, p 0 (2009)

Uno de los pilares fundamentales de la seguridad transfusional es la obtención de sangre a partir de donantes altruistas. Las colectas de sangre con equipos móviles es una estrategia que favorece este tipo de donaciones. En este artículo se descri

Externí odkaz: https://doaj.org/article/9e05d2587fc2464dbaef224a2658a0db

G9a/DNMT1 co-targeting inhibits non-small cell lung cancer growth and reprograms tumor cells to respond to cancer-drugs through SCARA5 and AOX1

Autor: Francisco Exposito, Miriam Redrado, Diego Serrano, Silvia Calabuig-Fariñas, Aida Bao-Caamano, Sandra Gallach, Eloisa Jantus-Lewintre, Angel Diaz-Lagares, Aitor Rodriguez-Casanova, Juan Sandoval, Edurne San Jose-Eneriz, Javier Garcia, Esther Redin, Yaiza Senent, Sergio Leon, Ruben Pio, Rafael Lopez, Julen Oyarzabal, Antonio Pineda-Lucena, Xabier Agirre, Luis M. Montuenga, Felipe Prosper, Alfonso Calvo

Publikováno v: Cell Death and Disease, Vol 15, Iss 11, Pp 1-16 (2024)

Abstract The treatment of non-small cell lung cancer (NSCLC) patients has significantly improved with recent therapeutic strategies; however, many patients still do not benefit from them. As a result, new treatment approaches are urgently needed. In

Externí odkaz: https://doaj.org/article/6e85bcef9c6c4041a19b62d5fdc24ce3

A new gas detection technique through cross-correlation with a complex aperiodic FBG

Autor: Matthew Rahme, Peter Tuthill, Christopher Betters, Maryanne Large, Sergio Leon-Saval

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Abstract Optical cross-correlation is a technique that can achieve both high specificity and high sensitivity when deployed as the basis for a sensing technology. Offering significant gains in cost, size and complexity, it can also deliver significan

Externí odkaz: https://doaj.org/article/a81b2e4ba3a74a7cae092a8658f639c3

3D Local Earthquake Tomography of the Ecuadorian Margin in the Source Area of the 2016 Mw 7.8 Pedernales Earthquake

Autor: Anne Meltzer, Mireille Laigle, Alexandra Alvarado, Mario Ruiz, Sergio León-Ríos, Silvana Hidalgo, A. Galve, Davide Oregioni, Jack Woollam, Hans Agurto-Detzel, Lidong Bie, Mariah Hoskins, Andreas Rietbrock, Susan L. Beck, Yvonne Font, Philippe Charvis

Publikováno v: Journal of Geophysical Research : Solid Earth
Journal of Geophysical Research : Solid Earth, American Geophysical Union, 2021, 126, ⟨10.1029/2020jb020701⟩
Journal of Geophysical Research : Solid Earth, 2021, 126, ⟨10.1029/2020jb020701⟩
Journal of Geophysical Research: Solid Earth, 126 (3), e2020JB020701

Based on manually analyzed waveforms recorded by the permanent Ecuadorian network and our large aftershock deployment installed after the Pedernales earthquake, we derive three‐dimensional Vp and Vp/Vs structures and earthquake locations for centra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fd58e13a4dcd1ec8b41e706b159b83
https://hal.archives-ouvertes.fr/hal-03291504