Zobrazeno 1 - 10
of 607
pro vyhledávání: '"Sergio Grinstein"'
Autor:
Hongxian Zhu, Andrew M. Sydor, Kirsten C. Boddy, Etienne Coyaud, Estelle M. N. Laurent, Aaron Au, Joel M. J. Tan, Bing-Ru Yan, Jason Moffat, Aleixo M. Muise, Christopher M. Yip, Sergio Grinstein, Brian Raught, John H. Brumell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Salmonella utilizes a type 3 secretion system to translocate virulence proteins (effectors) into host cells during infection1. The effectors modulate host cell machinery to drive uptake of the bacteria into vacuoles, where they can establish
Externí odkaz:
https://doaj.org/article/cb972bdf39654deca965043e86fecd62
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 1, Pp 151382- (2024)
The ongoing phagocytic activity of macrophages necessitates an extraordinary capacity to digest and resolve incoming material. While the initial steps leading to the formation of a terminal phagolysosome are well studied, much less is known about the
Externí odkaz:
https://doaj.org/article/f07f20a17f20420595cd112d07adbcb7
Autor:
Nicola T. Case, Johannes Westman, Michael T. Hallett, Jonathan Plumb, Aiman Farheen, Michelle E. Maxson, Jessie MacAlpine, Sean D. Liston, Bernhard Hube, Nicole Robbins, Luke Whitesell, Sergio Grinstein, Leah E. Cowen
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTFor the human fungal pathogen Candida albicans, metabolic flexibility and the ability to transition between yeast and filamentous growth states are key virulence traits that enable disease in the host. These traits are particularly important
Externí odkaz:
https://doaj.org/article/9701e5721a294187994ac9a51a0381cf
Autor:
Vikrant K Bhosle, Chunxiang Sun, Sajedabanu Patel, Tse Wing Winnie Ho, Johannes Westman, Dustin A Ammendolia, Fatemeh Mirshafiei Langari, Noah Fine, Nicole Toepfner, Zhubing Li, Manraj Sharma, Judah Glogauer, Mariana I Capurro, Nicola L Jones, Jason T Maynes, Warren L Lee, Michael Glogauer, Sergio Grinstein, Lisa A Robinson
Publikováno v:
eLife, Vol 12 (2023)
Neutrophils are essential for host defense against Staphylococcus aureus (S. aureus). The neuro-repellent, SLIT2, potently inhibits neutrophil chemotaxis, and might, therefore, be expected to impair antibacterial responses. We report here that, unexp
Externí odkaz:
https://doaj.org/article/eca449b6b5224e2b93b1b9e25a20e44b
Autor:
Jennifer L. Johnson, Elsa Meneses-Salas, Mahalakshmi Ramadass, Jlenia Monfregola, Farhana Rahman, Raquel Carvalho Gontijo, William B. Kiosses, Kersi Pestonjamasp, Dale Allen, Jinzhong Zhang, Douglas G. Osborne, Yanfang Peipei Zhu, Nathan Wineinger, Kasra Askari, Danni Chen, Juan Yu, Scott C. Henderson, Catherine C. Hedrick, Matilde Valeria Ursini, Sergio Grinstein, Daniel D. Billadeau, Sergio D. Catz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
Responsive exocytosis in neutrophil leukocytes involves actin depolymerisation-dependent sequential release of gelatinase granules, then strongly pro-inflammatory azurophilic granules. Here authors show that the actin nucleator protein WASH facilitat
Externí odkaz:
https://doaj.org/article/9638c498eebb49f28ed25260528bc5a9
Autor:
Joel M. J. Tan, Monica E. Garner, James M. Regeimbal, Catherine J. Greene, Jorge D. Rojas Márquez, Dustin A. Ammendolia, Adam R. R. McCluggage, Taoyingnan Li, Katherine J. Wu, Marija Cemma, Philip P. Ostrowski, Brian Raught, Michael S. Diamond, Sergio Grinstein, Robin M. Yates, Darren E. Higgins, John H. Brumell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Interferon (IFN) is an important component of antiviral immunity, but can also be exploited by bacteria for immune evasion. Here the authors show that Listeria monocytogenes (Lm) induces type I IFN to suppress the degradation of Lm virulence proteins
Externí odkaz:
https://doaj.org/article/ec11a9708c984975be93768c9db2c7f1
Autor:
Kirsten C. Boddy, Hongxian Zhu, Vanessa M. D’Costa, Caishuang Xu, Ksenia Beyrakhova, Miroslaw Cygler, Sergio Grinstein, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Brian Raught, John H. Brumell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Salmonella secretes the effector protein SopD into the host cell cytoplasm, leading to scission of the plasma membrane through unclear mechanisms. Here, Boddy et al. show that SopD binds to and inhibits the small GTPase Rab10, thus promoting removal
Externí odkaz:
https://doaj.org/article/c637d11be435406898ecf3fc34ead099
Autor:
Vikrant K. Bhosle, Tapas Mukherjee, Yi-Wei Huang, Sajedabanu Patel, Bo Wen (Frank) Pang, Guang-Ying Liu, Michael Glogauer, Jane Y. Wu, Dana J. Philpott, Sergio Grinstein, Lisa A. Robinson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Macrophages survey their surroundings using macropinocytosis, but its regulation is unclear. Here, the authors report that SLIT2, a known inhibitor of Rac GTPases, is an endogenous inhibitor of macropinocytosis, and that SLIT2 limits the uptake of NO
Externí odkaz:
https://doaj.org/article/155a4ff4159741ce9f07b911d6e0af13
Autor:
Saskia Heybrock, Kristiina Kanerva, Ying Meng, Chris Ing, Anna Liang, Zi-Jian Xiong, Xialian Weng, Young Ah Kim, Richard Collins, William Trimble, Régis Pomès, Gilbert G. Privé, Wim Annaert, Michael Schwake, Joerg Heeren, Renate Lüllmann-Rauch, Sergio Grinstein, Elina Ikonen, Paul Saftig, Dante Neculai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Cholesterol transport is tightly regulated in the cell and in lysosomes is regulated by NPC1/2. Here, Heybrock et al. use molecular modeling, knockout mice and cell based studies to show that LIMP-2 also mediates lysosomal cholesterol transport.
Externí odkaz:
https://doaj.org/article/7ad18a0cfcb742e09b108e2916ba4cfd
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The dynamic re-organization of cellular membranes in response to extracellular stimuli is fundamental to the cell physiology of myeloid and lymphoid cells of the immune system. In addition to maintaining cellular homeostatic functions, remodeling of
Externí odkaz:
https://doaj.org/article/eb5816d9f36a435db0d7c559b582933d