Origins of context-dependent gene repression by capicua.

Autor: Marta Forés, Leiore Ajuria, Núria Samper, Sergio Astigarraga, Claudia Nieva, Rona Grossman, Sergio González-Crespo, Ze'ev Paroush, Gerardo Jiménez

Publikováno v: PLoS Genetics, Vol 11, Iss 1, p e1004902 (2015)

Receptor Tyrosine Kinase (RTK) signaling pathways induce multiple biological responses, often by regulating the expression of downstream genes. The HMG-box protein Capicua (Cic) is a transcriptional repressor that is downregulated in response to RTK

Externí odkaz: https://doaj.org/article/df9a41c48481449fa41a6cb4b62a5d3f

Noncanonical function of Capicua as a growth termination signal in Drosophila oogenesis

Autor: Laura Rodríguez-Muñoz, Clàudia Lagares, Sergio González-Crespo, Pau Castel, Alexey Veraksa, Gerardo Jiménez

Capicua (Cic) proteins are conserved HMG-box transcriptional repressors that control receptor tyrosine kinase (RTK) signaling responses and are implicated in human neurological syndromes and cancer. While Cic is known to exist as short (Cic-S) and lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba3da8ce84ce5ad09fc7f92bc485d77
http://hdl.handle.net/10261/285493

A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer

Autor: Mariano Barbacid, Matthias Drosten, Sergio González-Crespo, Gerardo Jiménez, Leiore Ajuria, Núria Samper, Lucía Simón-Carrasco, Marta Forés

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS Genetics, Vol 13, Iss 3, p e1006622 (2017)
PLoS Genetics
Digital.CSIC. Repositorio Institucional del CSIC
instname

HMG-box proteins, including Sox/SRY (Sox) and TCF/LEF1 (TCF) family members, bind DNA via their HMG-box. This binding, however, is relatively weak and both Sox and TCF factors employ distinct mechanisms for enhancing their affinity and specificity fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0094e3a09e55c9184268abdc4d535b8
http://hdl.handle.net/20.500.12105/7232

Differential splicing of the growth hormone-releasing hormone gene in rat placenta generates a novel pre-proGHRH mRNA that encodes a different C-terminal flanking peptide 1

Autor: Sergio González-Crespo, Albert Boronat, Mercè Pérez-Riba

Publikováno v: FEBS Letters. 402:273-276

We have isolated and characterized a novel rat placental pre-proGHRH mRNA (pre-proGHRH-2 mRNA). This mRNA is generated by an alternative splicing process which results in the presence of an additional exon of 156 bp (designated exon 4.5) located betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca82cd7106c29cb9d0ba6f037a1aee75
https://doi.org/10.1016/s0014-5793(97)00003-3

EGFR-dependent downregulation of Capicua and the establishment of Drosophila dorsoventral polarity

Autor: María José Andreu, Núria Samper, Gerardo Jiménez, Sergio González-Crespo, Esther González-Pérez, Leiore Ajuria, Sonsoles Campuzano

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Dorsoventral (DV) axis formation in Drosophila begins during oogenesis through the graded activation of the EGF receptor (EGFR)-Ras-MAPK signaling pathway in the follicle cell layer of the egg chamber. EGFR signaling, which is higher in dorsal follic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bddfad5d8bfea3865d587c8a9c2dcd
http://hdl.handle.net/10261/87860