T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis

Autor: Rita C Bittar, Ricardo S Nogueira, Ricardo Vieira-Gonçalves, Vanessa Pinho-Ribeiro, Marise S Mattos, Manoel Paes Oliveira-Neto, Sergio G Coutinho, Alda M Da-Cruz

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 102, Iss 5, Pp 625-630 (2007)

Subclinical or asymptomatic infection is documented in individuals living in endemic areas for leishmaniasis suggesting that the development of an appropriate immune response can control parasite replication and maintain tissue integrity. A low morbi

Externí odkaz: https://doaj.org/article/1ea093600b3c42cb834511bd1e3fbe48

Tumor necrosis factor-α in human American tegumentary leishmaniasis

Autor: Alda Maria Da-Cruz, Márcia Pereira de Oliveira, Paula Mello De Luca, Sergio CF Mendonça, Sergio G Coutinho

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 91, Iss 2, Pp 225-229 (1996)

Tumor necrosis factor-alpha (TNF-α) is a cytokine produced by activated macrophages and other cells. In order to verify whether the serum levels of TNF-α in American tegumentary leishmaniasis patients are associated with the process of cure or aggr

Externí odkaz: https://doaj.org/article/f8716001c46c42d4827a8bab1deb6885

Antigen-triggered interferon-γ and interleukin-10 pattern in cured mucosal leishmaniasis patients is shaped during the active phase of disease

Autor: Valdir Sabbaga Amato, Adriano Gomes-Silva, Sergio G. Coutinho, Rita de Cássia Bittar, Alda Maria Da-Cruz, R. S. Nogueira, D. Silva Mendonça, M. da Silva Mattos, M. P. Oliveira-Neto

Publikováno v: Clinical and Experimental Immunology

Summary An exacerbated type 1 response to leishmanial antigens is the basis of tissue destruction observed in mucosal leishmaniasis (ML). After therapy, a persistent production of high levels of inflammatory cytokines can confer a poor prognosis. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219af734227015179ddb6da2aae7fd73
http://europepmc.org/articles/PMC4137852

T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis

Autor: Alda Maria Da-Cruz, Manoel P. Oliveira-Neto, Marise Mattos, Rita de Cássia Bittar, R. S. Nogueira, Sergio G. Coutinho, Ricardo Vieira-Gonçalves, Vanessa Pinho-Ribeiro

Publikováno v: Memórias do Instituto Oswaldo Cruz., Vol 102, Iss 5, Pp 625-630 (2007)
Memórias do Instituto Oswaldo Cruz, Volume: 102, Issue: 5, Pages: 625-630, Published: 12 JUL 2007

Subclinical or asymptomatic infection is documented in individuals living in endemic areas for leishmaniasis suggesting that the development of an appropriate immune response can control parasite replication and maintain tissue integrity. A low morbi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe38d6f9a2e349cc4cb289644ccf0827
https://doi.org/10.1590/s0074-02762007005000069

Study of the safety, immunogenicity and efficacy of attenuated and killed Leishmania (Leishmania) major vaccines in a rhesus monkey (Macaca mulatta) model of the human disease

Autor: Gabriel Grimaldi, Antonio Teva, Renato Porrozzi, Stephen M. Beverley, Elisa Cupolillo, Sergio G. Coutinho, V. F. Amaral, A. J. Silva, Claude Pirmez, M. S. Pereira, M. P. Oliveira-Neto

Publikováno v: Memórias do Instituto Oswaldo Cruz., Vol 97, Iss 7, Pp 1041-1048 (2002)
Memórias do Instituto Oswaldo Cruz, Volume: 97, Issue: 7, Pages: 1041-1048, Published: OCT 2002
Scopus-Elsevier

We have compared the efficacy of two Leishmania (Leishmania) major vaccines, one genetically attenuated (DHFR-TS deficient organisms), the other inactivated [autoclaved promastigotes (ALM) with bacillus Calmete-Guérin (BCG)], in protecting rhesus ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c27131bdf458793df9b88ea46748903
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000700019