Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sergio G, Peisajovich"'
Autor:
Amy Huei-Yi Lee, D. Patrick Bastedo, Ji-Young Youn, Timothy Lo, Maggie A. Middleton, Inga Kireeva, Jee Yeon Lee, Sara Sharifpoor, Anastasia Baryshnikova, Jianfeng Zhang, Pauline W. Wang, Sergio G. Peisajovich, Michael Constanzo, Brenda J. Andrews, Charles M. Boone, Darrell Desveaux, David S. Guttman
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 2, Pp 535-547 (2019)
Gram-negative bacterial pathogens inject type III secreted effectors (T3SEs) directly into host cells to promote pathogen fitness by manipulating host cellular processes. Despite their crucial role in promoting virulence, relatively few T3SEs have we
Externí odkaz:
https://doaj.org/article/1b9e884404934edc985db608a85c9aac
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Co-evolution of a new receptor-ligand pair will affect the downstream signal transduction network. Here, the authors use experimental evolution of yeast mating receptor Ste2 to show the effect of enhanced binding affinity and weakened interactions wi
Externí odkaz:
https://doaj.org/article/9ab4275031444dcfa4916e9056cc45fb
Autor:
Francisco J. Quintana, Agustin Plasencia, Zhaorong Li, Steven K Chen, Sergio G. Peisajovich, Benjamin M. Scott, Patrick Hewson, Pedro M. Moraes-Vieira, Laura M. Cox, Madelynn O'Brien, Jessica A da Silva Pereira, Cristina Gutiérrez-Vázquez, Belinda S. W. Chang, Liliana Maria Sanmarco
Publikováno v:
Nature Medicine. 27:1212-1222
Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal tract. Extracellular adenosine triphosphate (eATP) produced by the commensal microbiota and host cells activates purinergic signaling, promoting intes
Autor:
Trina Faye Osothprarop, Maybelle K. Go, Wen Shan Yew, Saurabh Nirantar, Alexander G Karabadzhak, Sergio G. Peisajovich, Jasmine Puay Suan Chua, Mcdonald Seth
Publikováno v:
ACS Synthetic Biology. 9:1725-1735
Terminal deoxynucleotidyl transferase (TdT) catalyzes template free incorporation of arbitrary nucleotides onto single-stranded DNA. Due to this unique feature, TdT is widely used in biotechnology and clinical applications. One particularly tantalizi
Publikováno v:
PLoS Biology, Vol 12, Iss 12, p e1002012 (2014)
The rearrangement of protein domains is known to have key roles in the evolution of signaling networks and, consequently, is a major tool used to synthetically rewire networks. However, natural mutational events leading to the creation of proteins wi
Externí odkaz:
https://doaj.org/article/ab4e4da02d9941469804c9b4fe0cd5df
Autor:
Benjamin M, Scott, Cristina, Gutiérrez-Vázquez, Liliana M, Sanmarco, Jessica A, da Silva Pereira, Zhaorong, Li, Agustín, Plasencia, Patrick, Hewson, Laura M, Cox, Madelynn, O'Brien, Steven K, Chen, Pedro M, Moraes-Vieira, Belinda S W, Chang, Sergio G, Peisajovich, Francisco J, Quintana
Publikováno v:
Nature medicine. 27(7)
Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal tract. Extracellular adenosine triphosphate (eATP) produced by the commensal microbiota and host cells activates purinergic signaling, promoting intes
Autor:
Elena Evdokimova, Olga Egorova, Alexander F. Yakunin, Sergio G. Peisajovich, Boguslaw Nocek, Alexei Savchenko, Purnima S. Kompella, Andrew T. Quaile, Alexander W. Ensminger, Dylan Valleau, Peter J. Stogios
Publikováno v:
Journal of Biological Chemistry. 293:3307-3320
Host colonization by Gram-negative pathogens often involves delivery of bacterial proteins called “effectors” into the host cell. The pneumonia-causing pathogen Legionella pneumophila delivers more than 330 effectors into the host cell via its ty
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports
G protein-coupled receptors (GPCRs) must discriminate between hundreds of related signal molecules. In order to better understand how GPCR specificity can arise from a common promiscuous ancestor, we used laboratory evolution to invert the specificit
Autor:
Benjamin M. Scott, Elise Heon, Belinda S. W. Chang, Leanne E. Wybenga-Groot, Sergio G. Peisajovich, C. Jane McGlade
Publikováno v:
SLAS discovery : advancing life sciences RD. 24(10)
Retinitis pigmentosa (RP) is a degenerative retinal disease, often caused by mutations in the G-protein-coupled receptor rhodopsin. The majority of pathogenic rhodopsin mutations cause rhodopsin to misfold, including P23H, disrupting its crucial abil
Autor:
Amy Huei-Yi, Lee, D Patrick, Bastedo, Ji-Young, Youn, Timothy, Lo, Maggie A, Middleton, Inga, Kireeva, Jee Yeon, Lee, Sara, Sharifpoor, Anastasia, Baryshnikova, Jianfeng, Zhang, Pauline W, Wang, Sergio G, Peisajovich, Michael, Constanzo, Brenda J, Andrews, Charles M, Boone, Darrell, Desveaux, David S, Guttman
Publikováno v:
G3: Genes|Genomes|Genetics
Gram-negative bacterial pathogens inject type III secreted effectors (T3SEs) directly into host cells to promote pathogen fitness by manipulating host cellular processes. Despite their crucial role in promoting virulence, relatively few T3SEs have we