Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Sergio E. Baranzini"'
Autor:
Tanuja Chitnis, Ferhan Qureshi, Victor M. Gehman, Michael Becich, Riley Bove, Bruce A. C. Cree, Refujia Gomez, Stephen L. Hauser, Roland G. Henry, Amal Katrib, Hrishikesh Lokhande, Anu Paul, Stacy J. Caillier, Adam Santaniello, Neda Sattarnezhad, Shrishti Saxena, Howard Weiner, Hajime Yano, Sergio E. Baranzini
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The multifaceted nature of multiple sclerosis requires quantitative biomarkers that can provide insights related to diverse physiological pathways. To this end, proteomic analysis of deeply-phenotyped serum samples, biological pathway modeli
Externí odkaz:
https://doaj.org/article/833d8dd5aeba4eed913b4c923942db14
Autor:
Qin Ma, Hengameh Shams, Alessandro Didonna, Sergio E. Baranzini, Bruce A. C. Cree, Stephen L. Hauser, Roland G. Henry, Jorge R. Oksenberg
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
The combined analysis of single cell and bulk epigenetic datasets and multiple sclerosis GWAS reveals the enrichment of genetic susceptibility signals in B cells and monocyte-microglia cell types.
Externí odkaz:
https://doaj.org/article/675d0cabbd474edfbffe9c5abc5657bf
Autor:
Karamarie Fecho, Anne E. Thessen, Sergio E. Baranzini, Chris Bizon, Jennifer J. Hadlock, Sui Huang, Ryan T. Roper, Noel Southall, Casey Ta, Paul B. Watkins, Mark D. Williams, Hao Xu, William Byrd, Vlado Dančík, Marc P. Duby, Michel Dumontier, Gustavo Glusman, Nomi L. Harris, Eugene W. Hinderer, Greg Hyde, Adam Johs, Andrew I. Su, Guangrong Qin, Qian Zhu, The Biomedical Data Translator Consortium
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 8, Pp 1838-1847 (2022)
Abstract Clinical, biomedical, and translational science has reached an inflection point in the breadth and diversity of available data and the potential impact of such data to improve human health and well‐being. However, the data are often siloed
Externí odkaz:
https://doaj.org/article/e60f6adb4b8840dba0f6a5708823c0c0
Autor:
Karthik Soman, Charlotte A. Nelson, Gabriel Cerono, Samuel M. Goldman, Sergio E. Baranzini, Ethan G. Brown
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionEarly diagnosis of Parkinson’s disease (PD) is important to identify treatments to slow neurodegeneration. People who develop PD often have symptoms before the disease manifests and may be coded as diagnoses in the electronic health rec
Externí odkaz:
https://doaj.org/article/814bed3af30e4b41b23cf6ab26fbd7ec
Autor:
Karamarie Fecho, Chris Bizon, Tursynay Issabekova, Sierra Moxon, Anne E. Thessen, Shervin Abdollahi, Sergio E. Baranzini, Basazin Belhu, William E. Byrd, Lawrence Chung, Andrew Crouse, Marc P. Duby, Stephen Ferguson, Aleksandra Foksinska, Laura Forero, Jennifer Friedman, Vicki Gardner, Gwênlyn Glusman, Jennifer Hadlock, Kristina Hanspers, Eugene Hinderer, Charlotte Hobbs, Gregory Hyde, Sui Huang, David Koslicki, Philip Mease, Sandrine Muller, Christopher J. Mungall, Stephen A. Ramsey, Jared Roach, Irit Rubin, Shepherd H. Schurman, Anath Shalev, Brett Smith, Karthik Soman, Sarah Stemann, Andrew I. Su, Casey Ta, Paul B. Watkins, Mark D. Williams, Chunlei Wu, Colleen H. Xu, The Biomedical Data Translator Consortium
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
Knowledge graphs have become a common approach for knowledge representation. Yet, the application of graph methodology is elusive due to the sheer number and complexity of knowledge sources. In addition, semantic incompatibilities hinder efforts to h
Externí odkaz:
https://doaj.org/article/8d108ce3ebbb408b85a7a73670319e07
Autor:
Andrés Cruz-Herranz, Frederike C. Oertel, Kicheol Kim, Ester Cantó, Garrett Timmons, Jung H. Sin, Michael Devereux, Nicholas Baker, Brady Michel, Ryan D. Schubert, Lakshmisahithi Rani, Christian Cordano, Sergio E. Baranzini, Ari J. Green
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
Neurodegeneration mediates neurological disability in inflammatory demyelinating diseases of the CNS. The role of innate immune cells in mediating this damage has remained controversial with evidence for destructive and protective effects. This has c
Externí odkaz:
https://doaj.org/article/01c7e3c7a8404c0582e553222861c0db
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The Scalable Precision Medicine Oriented Knowledge Engine (SPOKE) is a heterogeneous knowledge network that integrates information from 29 public databases. Here, Nelson et al. extend SPOKE to embed clinical data from electronic health records to cre
Externí odkaz:
https://doaj.org/article/ec5f2e03ddca4481a742ae0cece62da4
Autor:
Gianmarco Bellucci, Chiara Ballerini, Rosella Mechelli, Rachele Bigi, Virginia Rinaldi, Roberta Reniè, Maria Chiara Buscarinu, Sergio E. Baranzini, Lohith Madireddy, Giuseppe Matarese, Marco Salvetti, Giovanni Ristori
Publikováno v:
F1000Research, Vol 9 (2020)
Background: Severe coronavirus disease 2019 (COVID-19) is associated with multiple comorbidities and is characterized by an auto-aggressive inflammatory state leading to massive collateral damage. To identify preventive and therapeutic strategies aga
Externí odkaz:
https://doaj.org/article/2f1c5e6d666b4cdaab16cb5ae2b48fdf
Autor:
Charlotte A. Nelson, Ana Uriarte Acuna, Amber M. Paul, Ryan T. Scott, Atul J. Butte, Egle Cekanaviciute, Sergio E. Baranzini, Sylvain V. Costes
Publikováno v:
Life, Vol 11, Iss 1, p 42 (2021)
There has long been an interest in understanding how the hazards from spaceflight may trigger or exacerbate human diseases. With the goal of advancing our knowledge on physiological changes during space travel, NASA GeneLab provides an open-source re
Externí odkaz:
https://doaj.org/article/de327389693b4a0681912ce532aa710d
Autor:
Egle Cekanaviciute, Anne-Katrin Pröbstel, Anna Thomann, Tessel F. Runia, Patrizia Casaccia, Ilana Katz Sand, Elizabeth Crabtree, Sneha Singh, John Morrissey, Patrick Barba, Refujia Gomez, Rob Knight, Sarkis Mazmanian, Jennifer Graves, Bruce A. C. Cree, Scott S. Zamvil, Sergio E. Baranzini
Publikováno v:
mSystems, Vol 3, Iss 6 (2018)
ABSTRACT Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by adaptive and innate immune system dysregulation. Recent work has revealed moderate alteration of gut microbial communities in subjects with MS an
Externí odkaz:
https://doaj.org/article/07223417309e46cd82acc9f777fac98c