Tumor Necrosis Factor Receptor-1 (p55) Deficiency Attenuates Tumor Growth and Intratumoral Angiogenesis and Stimulates CD8+ T Cell Function in Melanoma

Autor: Yamila I. Rodriguez, Ludmila E. Campos, Melina G. Castro, Nadia Bannoud, Ada G. Blidner, Verónica P. Filippa, Diego O. Croci, Gabriel A. Rabinovich, Sergio E. Alvarez

Publikováno v: Cells, Vol 9, Iss 11, p 2469 (2020)

The role of tumor necrosis factor-α (TNF-α) in shaping the tumor microenvironment is ambiguous. Consistent with its uncertain role in melanoma, TNF-α plays a dual role, either acting as a cytotoxic cytokine or favoring a tumorigenic inflammatory m

Externí odkaz: https://doaj.org/article/0624a3162ac64691a87d4bdecedb176a

Tumor necrosis Factor Receptor-1 (p55) deficiency attenuates tumor growth and intratumoral angiogenesis and stimulates CD8+ T cell function in melanoma

Autor: Ludmila Estefanía Campos, Veronica Palmira Filippa, Gabriel A. Rabinovich, Nadia Bannoud, Yamila I. Rodriguez, Sergio E. Alvarez, Melina Gabriela Castro, Diego O. Croci, Ada G. Blidner

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cells
Volume 9
Issue 11
Cells, Vol 9, Iss 2469, p 2469 (2020)

The role of tumor necrosis factor-&alpha
(TNF-&alpha
) in shaping the tumor microenvironment is ambiguous. Consistent with its uncertain role in melanoma, TNF-&alpha
plays a dual role, either acting as a cytotoxic cytokine or favoring

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a981a6f12c05b19c2ac7ff622603ab7
https://www.mdpi.com/2073-4409/9/11/2469

Searching new structural scaffolds for BRAF inhibitors. An integrative study using theoretical and experimental techniques

Autor: Jiri Kos, Pavlina Marvanova, Josef Jampilek, Petr Mokry, Nace Zidar, Danijel Kikelj, Emilio Angelina, Ludmila Estefanía Campos, Tihomir Tomašič, Tomas Gonec, Francisco Matías Garibotto, Sergio E. Alvarez, Ricardo D. Enriz

The identification of the V600E activating mutation in the protein kinase BRAF in around 50% of melanoma patients has driven the development of highly potent small inhibitors (BRAFi) of the mutated protein. To date, Dabrafenib and Vemurafenib, two sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175d7ad075e36c26cd8168750bd91519
https://www.sciencedirect.com/science/article/abs/pii/S0045206819305322

Synthesis and biological evaluation of sphingosine kinase 2 inhibitors with anti-inflammatory activity

Autor: Jan Tengler, Santiago Lima, Lina María Vélez Acosta, Ivan Malík, Josef Jampilek, María José Sanz, Sarah Spiegel, Sergio E. Alvarez, Felipe Yépes, Nuria Cabedo, Justo Cobo, Marcela Cristina Vettorazzi, Patrice Marques, Alirio Palma, Laura Vila, Ricardo D. Enriz

Publikováno v: Archiv der Pharmazie. 352(3)

The synthesis of inhibitors of SphK2 with novel structural scaffolds is reported. These compounds were designed from a molecular modeling study, in which the molecular interactions stabilizing the different complexes were taken into account. Particul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1796d3a44cacebbb305ca1e91c841364
https://pubmed.ncbi.nlm.nih.gov/30648282

In Vitro Methods to Study the Modulation of Migration and Invasion by Sphingosine-1-Phosphate

Autor: Melina G, Castro, Ludmila E, Campos, Yamila I, Rodriguez, Sergio E, Alvarez

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1697

Sphingosine-1-phosphate (S1P) is a bioactive lipid that modulates migratory behavior of cells during embryonic development. In addition, S1P might promote tumor progression by enhancing migratory ability and invasiveness of tumor cells. Migration is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::194a0b9381757f168bf58d4f35867cd3
https://pubmed.ncbi.nlm.nih.gov/28755279