Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Sergio Di-Marco"'
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 932 (2024)
Translation is one of the main gene expression steps targeted by cellular stress, commonly referred to as translational stress, which includes treatment with anticancer drugs. While translational stress blocks the translation initiation of bulk mRNAs
Externí odkaz:
https://doaj.org/article/4b8f1902f8ea43bc884154ca48b1ba66
Autor:
Amr Omer, Monica Cruz Barrera, Julian L. Moran, Xian J. Lian, Sergio Di Marco, Christian Beausejour, Imed-Eddine Gallouzi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The mechanisms that control the deleterious behaviour of senescent cells is unclear. Here, the authors show that G3BP1 is required for the induction of the senescence-associated secretory phenotype (SASP), without affecting senescence, and that SASP
Externí odkaz:
https://doaj.org/article/02292b1787c3465190c76cee31b72257
Autor:
Brenda Janice Sánchez, Anne-Marie K. Tremblay, Jean-Philippe Leduc-Gaudet, Derek T. Hall, Erzsebet Kovacs, Jennifer F. Ma, Souad Mubaid, Patricia L. Hallauer, Brittany L. Phillips, Katherine E. Vest, Anita H. Corbett, Dimitris L. Kontoyiannis, Sabah N. A. Hussain, Kenneth E. M. Hastings, Sergio Di Marco, Imed-Eddine Gallouzi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
HuR is an RNA-binding protein that regulates myotube differentiation in vitro. Here, the authors show that the muscle-specific ablation of HuR in mice leads to enhanced endurance capacity and an increase in oxidative fibres by destabilising PGC1α-mR
Externí odkaz:
https://doaj.org/article/abbd8d839dcd49f5a47e7010f27a777f
Autor:
Derek T Hall, Takla Griss, Jennifer F Ma, Brenda Janice Sanchez, Jason Sadek, Anne Marie K Tremblay, Souad Mubaid, Amr Omer, Rebecca J Ford, Nathalie Bedard, Arnim Pause, Simon S Wing, Sergio Di Marco, Gregory R Steinberg, Russell G Jones, Imed‐Eddine Gallouzi
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 7, Pp 1-23 (2018)
Abstract Activation of AMPK has been associated with pro‐atrophic signaling in muscle. However, AMPK also has anti‐inflammatory effects, suggesting that in cachexia, a syndrome of inflammatory‐driven muscle wasting, AMPK activation could be ben
Externí odkaz:
https://doaj.org/article/a8b3c211642c4712934b7dbd386af718
Autor:
Brenda Janice Sánchez, Souad Mubaid, Sandrine Busque, Yossef Lopez de los Santos, Kholoud Ashour, Jason Sadek, Xian Jin Lian, Shahryar Khattak, Sergio Di Marco, Imed-Eddine Gallouzi
Publikováno v:
Nucleic Acids Research. 51:1375-1392
mRNA stability is the mechanism by which cells protect transcripts allowing their expression to execute various functions that affect cell metabolism and fate. It is well-established that RNA binding proteins (RBPs) such as HuR use their ability to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba49860b504f8eeba004d8d2b40a6246
https://doi.org/10.1093/nar/gkac1245
https://doi.org/10.1093/nar/gkac1245
Autor:
Noof Aloufi, Zahraa Haidar, Jun Ding, Parameswaran Nair, Andrea Benedetti, David H. Eidelman, Imed-Eddine Gallouzi, Sergio Di Marco, Sabah N. Hussain, Carolyn J. Baglole
Publikováno v:
Cells, Vol 11, Iss 1, p 22 (2021)
Patients with COPD may be at an increased risk for severe illness from COVID-19 because of ACE2 upregulation, the entry receptor for SARS-CoV-2. Chronic exposure to cigarette smoke, the main risk factor for COPD, increases pulmonary ACE2. How ACE2 ex
Externí odkaz:
https://doaj.org/article/33dc676cb1ae40e49b68efeea96f443e
Autor:
Xian J. Lian, Amr Omer, Imed-Eddine Gallouzi, Sergio Di Marco, Julian Lucas Moran, Monica Cruz Barrera, Christian Beauséjour
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Cellular senescence is a known driver of carcinogenesis and age-related diseases, yet senescence is required for various physiological processes. However, the mechanisms and factors that control the negative effects of senescence while retaining its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a01ffeff312e25f58cfceb3ed534adb
http://link.springer.com/article/10.1038/s41467-020-18734-9
http://link.springer.com/article/10.1038/s41467-020-18734-9
Autor:
Sergio Di Marco, Jean-Philippe Leduc-Gaudet, Jennifer F. Ma, Imed-Eddine Gallouzi, Erzsébet Nagy Kovács, Brittany L. Phillips, Anne-Marie K. Tremblay, Patricia L. Hallauer, Kenneth E. M. Hastings, Dimitris L. Kontoyiannis, Souad Mubaid, Derek T Hall, Brenda Janice Sanchez, Sabah N. A. Hussain, Katherine E. Vest, Anita H. Corbett
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
The master posttranscriptional regulator HuR promotes muscle fiber formation in cultured muscle cells. However, its impact on muscle physiology and function in vivo is still unclear. Here, we show that muscle-specific HuR knockout (muHuR-KO) mice hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215c2cbd621f6d91ed16c6cb8a4fb812
http://link.springer.com/article/10.1038/s41467-019-12186-6
http://link.springer.com/article/10.1038/s41467-019-12186-6
Autor:
Marco Bianchi, Bianca Colalillo, Amr Omer, Sergio Di Marco, William J. Muller, Jason Sadek, Imed-Eddine Gallouzi, Anne-Marie K. Tremblay, Virginie Sanguin-Gendreau, Derek T Hall
Publikováno v:
EMBO Molecular Medicine
Cachexia syndrome develops in patients with diseases such as cancer and sepsis and is characterized by progressive muscle wasting. While iNOS is one of the main effectors of cachexia, its mechanism of action and whether it could be targeted for thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a195e48ec4ebe0cc9cc9b657340896b3
https://doi.org/10.15252/emmm.202013591
https://doi.org/10.15252/emmm.202013591
Autor:
Imed E Gallouzi, Eric S. White, Ilan Azuelos, Carolyn J. Baglole, Noof Aloufi, Xingxing Liu, Sergio Di Marco, Hussein Traboulsi, Steven K. Huang, Parameswaran Nair, Christina K. Haston, David H. Eidelman, Fatmah Al-Habeeb
Publikováno v:
J Cell Physiol
Idiopathic pulmonary fibrosis (IPF) is a disease of progressive scarring caused by excessive extracellular matrix (ECM) deposition and activation of α-SMA-expressing myofibroblasts. Human antigen R (HuR) is an RNA binding protein that promotes prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e790b2e62f8ccf761cc798af2c3e7947
https://pubmed.ncbi.nlm.nih.gov/33855709
https://pubmed.ncbi.nlm.nih.gov/33855709