Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sergio De Munari"'
Autor:
Laura Gatti, Elisabetta Corna, Gianluca Pardi, Cecilia Allievi, Nicoli Paola, Franco Zunino, N. Carenini, Stefano Di Giovine, Jack W. Singer, Mario Grugni, Sergio De Munari, P Apostoli, Marco Natangelo, Gabriella Pezzoni, Paola Perego, Roberto Leone, Ulla Bastrup
Publikováno v:
Molecular Pharmaceutics. 7:207-216
Multinuclear platinum complexes are characterized by a peculiar DNA binding mode and higher cytotoxic potency than the mononuclear complexes, and efficacy against a wide range of preclinical tumor models. To reduce the high irreversible plasma protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66af44946ceb71b090dae74cef8a579
https://doi.org/10.1021/mp900211j
https://doi.org/10.1021/mp900211j
Autor:
Isabella Molinari, Paolo Barassi, Sergio De Munari, Nicoletta Almirante, Alberto Cerri, Piero Melloni, Giuseppe Marazzi, Alessandra Benicchio, Fulvio Serra
Publikováno v:
Journal of Medicinal Chemistry. 45:189-207
A series of 5-substituted (3aS,7aR)-7a-methylperhydroinden-3a-ol derivatives bearing a 1(S)-(omega-aminoalkoxy)iminoalkyl or -alkenyl substituent was synthesized, starting from the Hajos-Parrish ketol 47, as simplified analogues of very potent 17beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb7f4b886d7317e8a6e45c67d2d7670
https://doi.org/10.1021/jm011001k
https://doi.org/10.1021/jm011001k
Publikováno v:
The Journal of Organic Chemistry. 61:9272-9279
Alcohols and 1,2-diols oxidation by o-iodoxybenzoic acid (IBX) has been examined by 1H-NMR spectroscopy. Reversible formation of reactive intermediates, iodic esters 5, has been observed, and their structures in DMSO-d6 solution have been defined as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af7c681259b3793d988c1409394ef455
https://doi.org/10.1021/jo961044m
https://doi.org/10.1021/jo961044m
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1619-1624
The 6′- and 7′-(3-furylmethyl) derivatives of endo-1′,2′,3′,4′-tetrahydro-1′,4′-ethano-2′-naphthylethanol 1 have been synthesized as simplified analogues of digitoxigenin. The skeleton was built starting from 3,4-dihydro-1,4-ethanon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd7b6100e0ac5a6b0b63a5c9eac302ce
https://doi.org/10.1039/p19940001619
https://doi.org/10.1039/p19940001619
Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer
Autor:
Sankar Chatterjee, John P. Mallamo, Ambrogio Oliva, Germano D'arasmo, Ernesto Menta, Ferretti Edmondo, Alberto Bernareggi, Bruce D. Dorsey, Ivan Strepponi, Bruce Ruggeri, Cecilia Allievi, Michael Williams, Gabriella Pezzoni, Cassara Paolo G, Mohamed Iqbal, Mark A. Ator, Sergio De Munari, Raffaella Bernardini
Publikováno v:
Journal of medicinal chemistry. 51(4)
The ubiquitin-proteasome pathway plays a central role in regulation of the production and destruction of cellular proteins. These pathways mediate proliferation and cell survival, particularly in malignant cells. The successful development of the 20S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a51f3b9283ddcb107c87685ef00a2ca
https://pubmed.ncbi.nlm.nih.gov/18247547
https://pubmed.ncbi.nlm.nih.gov/18247547
Publikováno v:
Synlett. 1998:1234-1236
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c600c3ea4c045eb79f3c895b83391ef
https://doi.org/10.1055/s-1998-1902
https://doi.org/10.1055/s-1998-1902
Autor:
Simona Sputore, Banfi Leonardo, Giulio Carzana, Sergio De Munari, Alberto Cerri, Piero Melloni, Patrizia Ferrari, R. Micheletti, Nicoletta Almirante, Giuseppe Marazzi, Antonio Schiavone, Marco Torri, Zappavigna Maria Pia, Mauro Gobbini
Publikováno v:
Journal of medicinal chemistry. 46(17)
The design, synthesis, and biological properties of novel inhibitors of the Na(+),K(+)-ATPase as potential positive inotropic compounds are reported. Following our model of superposition between cassaine and digitoxigenin, digitalis-like activity has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9d99cb5c79ae1addefaf1eabdcdfaa
https://pubmed.ncbi.nlm.nih.gov/12904068
https://pubmed.ncbi.nlm.nih.gov/12904068
Publikováno v:
Chemistry Letters. 39:676-677
The 1H NMR characterization of the encapsulation of bisplatinum complex CT-3610 by cucurbit[7]uril is reported. The formation of the intermediate monoinclusion complex can be easily detected in the...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eb47dc1142a49d2b40187f3e3ce5047
https://doi.org/10.1246/cl.2010.676
https://doi.org/10.1246/cl.2010.676
Autor:
Ernesto Menta, Sergio De Munari, Ambrogio Oliva, Raffaella Bernardini, Alessandro Paganelli, Luca Goldoni, Mario Grugni
Publikováno v:
Chemistry Letters. 38:750-751
Boronic esters are key intermediates in the synthesis of biologically active compounds such as thrombin and proteasome inhibitors. However, they have low hydrolytic stability both during synthetic ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcb75da452151a57ff2aaf6404d57dc3
https://doi.org/10.1246/cl.2009.750
https://doi.org/10.1246/cl.2009.750
Autor:
Bruce D. Dorsey, Mohamed Iqbal, Sankar Chatterjee, Bruce Ruggeri, Mark A. Ator, Michael Williams, John P. Mallamo, Ernesto Menta, Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassarà, Germano D’Arasmo, Edmondo Ferretti, Sergio De Munari, Ambrogio Oliva, Gabriella Pezzoni, Cecilia Allievi, Ivan Strepponi
Publikováno v:
Journal of Medicinal Chemistry; Jan2008, Vol. 51 Issue 4, p1068-1072, 5p