Imaging and Quantification of mRNA Molecules at Single-Cell Resolution in the Human Fungal Pathogen Candida albicans

Autor: Sergio D. Moreno-Velásquez, J. Christian Pérez

Publikováno v: mSphere, Vol 6, Iss 4 (2021)

Tools to visualize and quantify transcripts at single-cell resolution have enabled the dissection of spatiotemporal patterns of gene expression in animal cells and tissues. Yet the accurate quantification of transcripts at single-cell resolution rema

Externí odkaz: https://doaj.org/article/aaee277e451b4670a579e1972a807f86

The Regulatory Proteins Rtg1/3 Govern Sphingolipid Homeostasis in the Human-Associated Yeast Candida albicans

Autor: Sergio D. Moreno-Velásquez, Su Hlaing Tint, Valentina del Olmo Toledo, Sanda Torsin, Sonakshi De, J. Christian Pérez

Publikováno v: Cell Reports, Vol 30, Iss 3, Pp 620-629.e6 (2020)

Summary: Integrating nutrient sensing with the synthesis of complex molecules is a central feature of metabolism. Yet the regulatory mechanisms underlying such integration are often unknown. Here, we establish that the transcription regulators Rtg1/3

Externí odkaz: https://doaj.org/article/adc91683a3664d5b898fcd5e6ad26184

Phagolysosomal Survival Enables Non-lytic Hyphal Escape and Ramification Through Lung Epithelium During Aspergillus fumigatus Infection

Autor: Paul Bowyer, Constanze Seidel, Sara Gago, Nick D. Read, Nagwa Ben-Ghazzi, Sergio D. Moreno-Velásquez

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)
Seidel, C, Moreno Velásquez, S S, Ben Ghazzi, N, Gago, S, Bowyer, P & Read, N 2020, ' Phagolysosomal survival enables non-lytic hyphal escape and ramification through lung epithelium during Aspergillus fumigatus infection ', Frontiers in Microbiology, vol. 11, 1955, pp. 1-13 . https://doi.org/10.3389/fmicb.2020.01955

Aspergillus fumigatus is the most important mould pathogen in immunosuppressed patients. Suboptimal clearance of inhaled spores results in the colonisation of the lung airways by invasive hyphae. The first point of contact between A. fumigatus and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec4dd0c2c4405651fdf8a05902fe7b3
https://doi.org/10.3389/fmicb.2020.01955

The Regulatory Proteins Rtg1/3 Govern Sphingolipid Homeostasis in the Human-Associated Yeast Candida albicans

Autor: J. Christian Pérez, Sonakshi De, Sergio D. Moreno-Velásquez, Sanda Torsin, Su Hlaing Tint, Valentina del Olmo Toledo

Publikováno v: Cell Reports, Vol 30, Iss 3, Pp 620-629.e6 (2020)

Summary: Integrating nutrient sensing with the synthesis of complex molecules is a central feature of metabolism. Yet the regulatory mechanisms underlying such integration are often unknown. Here, we establish that the transcription regulators Rtg1/3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be4d018a21f60855fc27ce4ff8aad01
https://doi.org/10.1016/j.celrep.2019.12.022