Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Sergio D Catz"'
Autor:
Gennaro Napolitano, Jennifer L Johnson, Jing He, Celine J Rocca, Jlenia Monfregola, Kersi Pestonjamasp, Stephanie Cherqui, Sergio D Catz
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 2, Pp 158-174 (2015)
Abstract Metabolite accumulation in lysosomal storage disorders (LSDs) results in impaired cell function and multi‐systemic disease. Although substrate reduction and lysosomal overload‐decreasing therapies can ameliorate disease progression, the
Externí odkaz:
https://doaj.org/article/df59719d2a204dc38c232652c20f5d27
Autor:
Tomoyuki Sasaki, Shanshan Lian, Jie Qi, Peter E Bayliss, Christopher E Carr, Jennifer L Johnson, Sujay Guha, Patrick Kobler, Sergio D Catz, Matthew Gill, Kailiang Jia, Daniel J Klionsky, Shuji Kishi
Publikováno v:
PLoS Genetics, Vol 10, Iss 6, p e1004409 (2014)
Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H+-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces aberrant autolysosome formation that leads to
Externí odkaz:
https://doaj.org/article/5401032689964a0d9bdd1ddd249a4334
Autor:
Jennifer L. Johnson, Elsa Meneses-Salas, Mahalakshmi Ramadass, Jlenia Monfregola, Farhana Rahman, Raquel Carvalho Gontijo, William B. Kiosses, Kersi Pestonjamasp, Dale Allen, Jinzhong Zhang, Douglas G. Osborne, Yanfang Peipei Zhu, Nathan Wineinger, Kasra Askari, Danni Chen, Juan Yu, Scott C. Henderson, Catherine C. Hedrick, Matilde Valeria Ursini, Sergio Grinstein, Daniel D. Billadeau, Sergio D. Catz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
Responsive exocytosis in neutrophil leukocytes involves actin depolymerisation-dependent sequential release of gelatinase granules, then strongly pro-inflammatory azurophilic granules. Here authors show that the actin nucleator protein WASH facilitat
Externí odkaz:
https://doaj.org/article/9638c498eebb49f28ed25260528bc5a9
Autor:
Mausita Karmakar, Martin Minns, Elyse N. Greenberg, Jose Diaz-Aponte, Kersi Pestonjamasp, Jennifer L. Johnson, Joseph K. Rathkey, Derek W. Abbott, Kun Wang, Feng Shao, Sergio D. Catz, George R. Dubyak, Eric Pearlman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
In macrophages, IL-1β secretion is mediated by N-GSDMD pores in the plasma membrane (PM). Here the authors show that in neutrophils, IL-1β secretion occurs in the absence of PM pores, via autophagosomes; N-GSDMD does not traffic to PM but to azurop
Externí odkaz:
https://doaj.org/article/e8657a099f0941af8558ca645f8e6b29
Autor:
Kersi Pestonjamasp, Stephanie Cherqui, Jennifer L. Johnson, Jing He, Farhana Rahman, Jinzhong Zhang, Sergio D. Catz
Publikováno v:
Autophagy, vol 18, iss 5
The dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated and the importance of individual subunits in maintaining cellular homeosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4805ad5e8183a450444bb9c5e7b46600
https://doi.org/10.1080/15548627.2021.1971937
https://doi.org/10.1080/15548627.2021.1971937
Autor:
Jennifer L. Johnson, Mahalakshmi Ramadass, Ariela Haimovich, Matthew D. McGeough, Jinzhong Zhang, Hal M. Hoffman, Sergio D. Catz
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Heterozygous mutations in the NLRP3 gene in patients with cryopyrin associated periodic syndrome (CAPS) lead to hyper-responsive inflammasome function. CAPS is a systemic auto-inflammatory syndrome characterized by the activation of the innate immune
Externí odkaz:
https://doaj.org/article/f256616a7b8d4637bd51e9ca8d87a202
Autor:
Sergio D. Catz, Kersi Pestonjamasp, Elsa Meneses-Salas, Catherine C. Hedrick, Raquel Carvalho Gontijo, Jenny E. Gunton, Mahalakshmi Ramadass, Gennaro Napolitano, Nadia R Zgajnar, Jennifer L. Johnson, William B. Kiosses, Yanfang Peipei Zhu, Farhana Rahman, Jinzhong Zhang, Marta Perego
Publikováno v:
Journal of Leukocyte Biology. 110:629-649
Despite the important function of neutrophils in the eradication of infections and induction of inflammation, the molecular mechanisms regulating the activation and termination of the neutrophil immune response is not well understood. Here, the funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2b789e55788f36115359e9261777eb
https://doi.org/10.1002/jlb.2hi0421-123r
https://doi.org/10.1002/jlb.2hi0421-123r
Autor:
Gennaro Napolitano, Jennifer L. Johnson, Farhana Rahman, Mahalakshmi Ramadass, Sergio D. Catz, Jing He, Jinzhong Zhang
Publikováno v:
Autophagy. 15:1738-1756
Several lines of evidence support the occurrence of cross-regulation between the endocytic pathway and autophagy, but the molecular mechanisms regulating this process are not well-understood. Here, we show that the calcium sensor UNC13D regulates the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4174592653448553bdde019a5ced9501
https://doi.org/10.1080/15548627.2019.1596475
https://doi.org/10.1080/15548627.2019.1596475
Autor:
Mahalakshmi Ramadass, Alex Marki, Jennifer L. Johnson, William B. Kiosses, Jinzhong Zhang, Sergio D. Catz, Kersi Pestonjamasp, Dennis Wolf, Klaus Ley
Publikováno v:
J Leukoc Biol
Neutrophil chemotaxis is essential in responses to infection and underlies inflammation. In neutrophils, the small GTPase Rac1 has discrete functions at both the leading edge and in the retraction of the trailing structure at the cell’s rear (uropo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6362bef70e9960744789f2019c52f67b
https://doi.org/10.1002/jlb.1vma0818-320r
https://doi.org/10.1002/jlb.1vma0818-320r
Autor:
Mu-qing Yang, Catherine J. Baty, Adrian E. Morelli, Mara Sullivan, Sergio D. Catz, Michel Calderon, William J. Shufesky, Mohna Bandyopadhyay, Todd V. Brennan, Martin H. Oberbarnscheidt, Rao Chen, Furong Zeng, Zhizhao Chen, Geza Erdos, Adriana T. Larregina, Donna B. Stolz, Simon C. Watkins, Roberta Pelanda, Geoffrey Camirand
Publikováno v:
Sci Transl Med
Despite the role of donor-specific antibodies (DSAs) in recognizing major histocompatibility complex (MHC) antigens and mediating transplant rejection, how and where recipient B cells in lymphoid tissues encounter donor MHC antigens remains unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c9c529e239358cc9252d9aeee79c2f
https://europepmc.org/articles/PMC8939235/
https://europepmc.org/articles/PMC8939235/
