Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Sergio C, Oliveira"'
Autor:
Vinícius M. Borges, Fábio V. Marinho, Christiane V. A. Caldeira, Nina M. G. P. de Queiroz, Sergio C. Oliveira
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Bacillus Calmette-Guérin (BCG) is the first line treatment for bladder cancer and it is also proposed for melanoma immunotherapy. BCG modulates the tumor microenvironment (TME) inducing an antitumor effective response, but the immune mechanisms invo
Externí odkaz:
https://doaj.org/article/30d522c2b4fd484682eb797e4c3bab77
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionGuanylate-binding proteins (GBPs) are produced in response to pro-inflammatory signals, mainly interferons. The most studied cluster of GBPs in mice is on chromosome 3. It comprises the genes for GBP1-to-3, GBP5 and GBP7. In humans, all G
Externí odkaz:
https://doaj.org/article/dd71e6ad182341d1b6fcfcc627d69d26
Autor:
Keyla S. G. de Sá, Luana A. Amaral, Tamara S. Rodrigues, Adriene Y. Ishimoto, Warrison A. C. de Andrade, Leticia de Almeida, Felipe Freitas-Castro, Sabrina S. Batah, Sergio C. Oliveira, Mônica T. Pastorello, Alexandre T. Fabro, Dario S. Zamboni
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Here, de Sá et al. show that Gasdermin-D is transiently activated in Leishmania-infected macrophages and promotes NLRP3 inflammasome activation, but not cell death. Gasdermin-D is cleaved into a noncanonical fragment, indicating that Leishmania subv
Externí odkaz:
https://doaj.org/article/1a83c20a305e4205a732e3e7fc4d594d
Autor:
Iván M. Alonso Paiva, Raiany A. Santos, Camila B. Brito, Mariana C. Ferrero, Juan Manuel Ortiz Wilczyñski, Eugenio A. Carrera Silva, Sergio C. Oliveira, Pablo C. Baldi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Despite the importance of the respiratory route for Brucella transmission, the lung immune response to this pathogen is scarcely characterized. We investigated the role of the cGAS/STING pathway of microbial DNA recognition in the control of respirat
Externí odkaz:
https://doaj.org/article/a63781fdbf924b1f99536cf78d642812
Autor:
Ana Carolina V. S. C. de Araujo, Fábio Mambelli, Rodrigo O. Sanches, Fábio V. Marinho, Sergio C. Oliveira
Publikováno v:
Pathogens, Vol 12, Iss 12, p 1386 (2023)
The bacillus Calmette–Guérin (BCG) is an attenuated bacterium derived from virulent Mycobacterium bovis. It is the only licensed vaccine used for preventing severe forms of tuberculosis in children. Besides its specific effects against tuberculosi
Externí odkaz:
https://doaj.org/article/4171cf10c5e84be78e55f3cd731b01b8
Autor:
Erika S. Guimarães, Marco Túlio R. Gomes, Rodrigo C. O. Sanches, Kely Catarine Matteucci, Fábio V. Marinho, Sergio C. Oliveira
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Endoplasmic reticulum (ER) stress plays a major role in several inflammatory disorders. ER stress induces the unfolded protein response (UPR), a conserved response broadly associated with innate immunity and cell metabolic function in various scenari
Externí odkaz:
https://doaj.org/article/1798356106eb4976bb88487db7c9a0e4
Autor:
Henry L. Gomez, Juan E. Bargallo-Rocha, Roberto J. Billinghurst, Aníbal R. Núñez De Pierro, Federico A. Coló, Lisandro L. B. Gil, Carola Allemand, Ignacio L. McLean, Mauricio Lema-Medina, Fernando Herazo-Maya, Francisco J. Terrier, Raquel G. Cwilich, Mauricio Leon, Silvia G. Falcon, Roberto E. Castaño, Sergio C. Oliveira, Debbie M. Jakubowski, Calvin Chao
Publikováno v:
JCO Global Oncology, Vol , Iss 7, Pp 1364-1373 (2021)
PURPOSEWe present a physician survey of the impact of 21-gene Breast Recurrence Score test results on treatment decisions in clinical practice in Latin America.METHODSThis prospective survey enrolled consecutive patients at 14 sites in Argentina, Col
Externí odkaz:
https://doaj.org/article/d419e7ed949e4df185a1e6c2f84e999c
Autor:
André Mattar, Guilherme R. Fonseca, Murilo B. A. Romão, Jorge Y. Shida, Vilmar M. de Oliveira, Maria C. S. Bastos, Fabio Bagnoli, Jose F. Rinaldi, Monica M. Á. Stiepcich, Maria A. L. G. da Silva, Debbie M. Jakubowski, Calvin Chao, Sergio C. Oliveira, Luiz H. Gebrim
Publikováno v:
JCO Global Oncology, Vol , Iss 7, Pp 1003-1011 (2021)
PURPOSEWe evaluated the impact of 21-gene test results on treatment decisions for patients with early-stage breast cancer treated under the public health care system in Brazil, Sistema Único de Saúde.METHODSEligible patients treated at Hospital Pé
Externí odkaz:
https://doaj.org/article/3bf8a39fc7094683939444319dace9c1
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Programmed cell death (PCD) is an important mechanism of innate immunity against bacterial pathogens. The innate immune PCD pathway involves the molecules caspase-7 and caspase-8, among others. Brucella abortus is a gram-negative bacterium that cause
Externí odkaz:
https://doaj.org/article/724788a135614e9db551fd8b22acfb80
Autor:
Nina M. G. P. de Queiroz, Fabio V. Marinho, Ana Carolina V. S. C. de Araujo, Julia S. Fahel, Sergio C. Oliveira
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Bacillus Calmette-Guerin (BCG) is the only FDA approved first line therapy for patients with nonmuscle invasive bladder cancer. The purpose of this study is to better understand the role of innate immune pathways involved in BCG immunotherap
Externí odkaz:
https://doaj.org/article/ca8937a512814b7b960d747443ddfd12