Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Sergio Anastasi"'
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Akademický článek
miR‐205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling
Autor: Cristina Migliore, Elena Morando, Elena Ghiso, Sergio Anastasi, Vera P Leoni, Maria Apicella, Davide Cora', Anna Sapino, Filippo Pietrantonio, Filippo De Braud, Amedeo Columbano, Oreste Segatto, Silvia Giordano
Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-12 (2018)
Abstract The onset of secondary resistance represents a major limitation to long‐term efficacy of target therapies in cancer patients. Thus, the identification of mechanisms mediating secondary resistance is the key to the rational design of therap
Externí odkaz: https://doaj.org/article/f09ddfa6e2014b34a62b8a6110de7ae3
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3
Making sense of Cbp/p300 loss of function mutations in skin tumorigenesis
Autor: Stefano Alemà, Sergio Anastasi, Oreste Segatto
Publikováno v: The Journal of Pathology. 250:3-6
CBP and p300 are highly homologous lysine acetyltransferases involved in cell cycle regulation, DNA synthesis and DNA repair. Loss of function mutations of CBP and p300 are found in about one-third of cutaneous squamous cell carcinoma (cSCC) and ofte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47017e5a62ba3c5a5cfd2f317e5c979
https://doi.org/10.1002/path.5336
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5
HSP90 Inhibition Drives Degradation of FGFR2 Fusion Proteins: Implications for Treatment of Cholangiocarcinoma
Autor: Oreste Segatto, Jan B. Egan, Manuela Porru, Carlo Leonetti, Simonetta Buglioni, Carla Azzurra Amoreo, Loriana Castellani, Sergio Anastasi, Giulia Cristinziano, Stefano Alemà, Dante Lamberti, Mitesh J. Borad, Chang Xin Shi
Publikováno v: Hepatology. 69:131-142
About 15% of intrahepatic cholangiocarcinomas (ICCs) express constitutively active fibroblast growth factor receptor 2 (FGFR2) fusion proteins (FFs) generated by chromosomal translocations. FFs have been nominated as oncogenic drivers because adminis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8326d94822d0926e3b6159ccf8383a8
https://doi.org/10.1002/hep.30127
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6
Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics
Autor: Sergio Anastasi, Oreste Segatto, Dante Lamberti, Stefano Alemà
Publikováno v: Seminars in cell & developmental biology 50 (2016): 115–124. doi:10.1016/j.semcdb.2015.10.001
info:cnr-pdr/source/autori:Anastasi S, Lamberti D, Alemà S, Segatto O/titolo:Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics/doi:10.1016%2Fj.semcdb.2015.10.001/rivista:Seminars in cell & developmental biology/anno:2016/pagina_da:115/pagina_a:124/intervallo_pagine:115–124/volume:50
The ErbB signaling network instructs the execution of key cellular programs, such as cell survival, proliferation and motility, through the generation of robust signals of defined strength and duration. In contrast, unabated ErbB signaling disrupts t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550582fa3d5c29f41f32335d66967e99
https://doi.org/10.1016/j.semcdb.2015.10.001
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7
miR-205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling
Autor: Vera Piera Leoni, Maria Apicella, Sergio Anastasi, Elena Morando, Oreste Segatto, Elena Ghiso, Filippo de Braud, Amedeo Columbano, Silvia Giordano, Cristina Migliore, Anna Sapino, Filippo Pietrantonio, Davide Corà
Publikováno v: EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 10, Iss 9, Pp n/a-n/a (2018)
The onset of secondary resistance represents a major limitation to long‐term efficacy of target therapies in cancer patients. Thus, the identification of mechanisms mediating secondary resistance is the key to the rational design of therapeutic str
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d54923bf4ca7c091fcb612c468fda6
http://hdl.handle.net/2318/1671637
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9
A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation
Autor: Simona Polo, Oreste Segatto, Giulia Varsano, Stefano Alemà, Loriana Castellani, Elena Maspero, Costanza Ballarò, Yuri Frosi, Sergio Anastasi
Publikováno v: The Journal of Cell Biology
The EGFR kinase inhibitor RALT/MIG6 also functions as an endocytic adaptor to promote receptor internalization by scaffolding AP-2 and intersectins.
Signaling by epidermal growth factor receptor (EGFR) must be controlled tightly because aberrant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d28d3df4f6f66a8105a0803e86c62f7
https://doi.org/10.1083/jcb.201002032
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10
The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity
Autor: Stefano Alemà, Oreste Segatto, Maria Francesca Baietti, Y Frosi, Sergio Anastasi
Publikováno v: Oncogene (Basingstoke) 26 (2007): 7833–7846.
info:cnr-pdr/source/autori:Anastasi S., Baietti M.F., Frosi Y., Alemà S. and Segatto O./titolo:The evolutionarily conserved EBR module of RALT%2FMIG6 mediates suppression of the EGFR catalytic activity/doi:/rivista:Oncogene (Basingstoke)/anno:2007/pagina_da:7833/pagina_a:7846/intervallo_pagine:7833–7846/volume:26
Physiological signalling by the epidermal growth factor receptor (EGFR) controls developmental processes and tissue homeostasis, whereas aberrant EGFR activity drives oncogenic cell transformation. Under normal conditions, the EGFR must therefore gen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ccc628863440b37e7139c8d2856094
https://doi.org/10.1038/sj.onc.1210590
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