Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sergio Anastasi"'
Autor:
Cristina Migliore, Elena Morando, Elena Ghiso, Sergio Anastasi, Vera P Leoni, Maria Apicella, Davide Cora', Anna Sapino, Filippo Pietrantonio, Filippo De Braud, Amedeo Columbano, Oreste Segatto, Silvia Giordano
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-12 (2018)
Abstract The onset of secondary resistance represents a major limitation to long‐term efficacy of target therapies in cancer patients. Thus, the identification of mechanisms mediating secondary resistance is the key to the rational design of therap
Externí odkaz:
https://doaj.org/article/f09ddfa6e2014b34a62b8a6110de7ae3
Autor:
Maria Grazia Diodoro, Mitesh J. Borad, Simonetta Buglioni, Giulia Cristinziano, Oreste Segatto, Isabella Manni, Giandomenico Russo, Carla Azzurra Amoreo, Mattia Forcato, Gian Luca Grazi, Cristina Cristofoletti, Andrea Sacconi, Diana Giannarelli, Manuela Porru, Carlo Leonetti, Dante Lamberti, Silvia Giordano, Francesca Rollo, Sergio Anastasi
Publikováno v:
Journal of Hepatology. 75:351-362
Background & Aims About 15% of intrahepatic cholangiocarcinomas (iCCAs) express fibroblast growth factor receptor 2 (FGFR2) fusion proteins (FFs), usually alongside mutational inactivation of TP53, CDKN2A or BAP1. In FFs, FGFR2 residues 1-768 fuse to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239ebbaf680e94db5bedd56cfa8e9284
https://doi.org/10.1016/j.jhep.2021.02.032
https://doi.org/10.1016/j.jhep.2021.02.032
Publikováno v:
The Journal of Pathology. 250:3-6
CBP and p300 are highly homologous lysine acetyltransferases involved in cell cycle regulation, DNA synthesis and DNA repair. Loss of function mutations of CBP and p300 are found in about one-third of cutaneous squamous cell carcinoma (cSCC) and ofte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47017e5a62ba3c5a5cfd2f317e5c979
https://doi.org/10.1002/path.5336
https://doi.org/10.1002/path.5336
Autor:
Oreste Segatto, Cristina Cristofoletti, Giandomenico Russo, Diana Giannarelli, Isabella Manni, Carla Azzurra Amoreo, Andrea Sacconi, Mattia Forcato, Gian Luca Grazi, Manuela Porru, Sergio Anastasi, Simonetta Buglioni, Giulia Cristinziano, Maria Grazia Diodoro, Mitesh J. Borad, Silvia Giordano, Carlo Leonetti, Dante Lamberti, Francesca Rollo
Background and aimsAbout 15% of intrahepatic cholangiocarcinoma (iCCA) express fibroblast growth factor receptor 2 (FGFR2) fusion proteins (FFs), most often in concert with mutationally inactivated TP53, CDKN2A or BAP1. FFs span residues 1-768 of FGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0115570d627d89e13f8cc88b009ec467
https://doi.org/10.1101/2020.05.20.106104
https://doi.org/10.1101/2020.05.20.106104
Autor:
Oreste Segatto, Jan B. Egan, Manuela Porru, Carlo Leonetti, Simonetta Buglioni, Carla Azzurra Amoreo, Loriana Castellani, Sergio Anastasi, Giulia Cristinziano, Stefano Alemà, Dante Lamberti, Mitesh J. Borad, Chang Xin Shi
Publikováno v:
Hepatology. 69:131-142
About 15% of intrahepatic cholangiocarcinomas (ICCs) express constitutively active fibroblast growth factor receptor 2 (FGFR2) fusion proteins (FFs) generated by chromosomal translocations. FFs have been nominated as oncogenic drivers because adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8326d94822d0926e3b6159ccf8383a8
https://doi.org/10.1002/hep.30127
https://doi.org/10.1002/hep.30127
Publikováno v:
Seminars in cell & developmental biology 50 (2016): 115–124. doi:10.1016/j.semcdb.2015.10.001
info:cnr-pdr/source/autori:Anastasi S, Lamberti D, Alemà S, Segatto O/titolo:Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics/doi:10.1016%2Fj.semcdb.2015.10.001/rivista:Seminars in cell & developmental biology/anno:2016/pagina_da:115/pagina_a:124/intervallo_pagine:115–124/volume:50
info:cnr-pdr/source/autori:Anastasi S, Lamberti D, Alemà S, Segatto O/titolo:Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics/doi:10.1016%2Fj.semcdb.2015.10.001/rivista:Seminars in cell & developmental biology/anno:2016/pagina_da:115/pagina_a:124/intervallo_pagine:115–124/volume:50
The ErbB signaling network instructs the execution of key cellular programs, such as cell survival, proliferation and motility, through the generation of robust signals of defined strength and duration. In contrast, unabated ErbB signaling disrupts t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550582fa3d5c29f41f32335d66967e99
https://doi.org/10.1016/j.semcdb.2015.10.001
https://doi.org/10.1016/j.semcdb.2015.10.001
Autor:
Vera Piera Leoni, Maria Apicella, Sergio Anastasi, Elena Morando, Oreste Segatto, Elena Ghiso, Filippo de Braud, Amedeo Columbano, Silvia Giordano, Cristina Migliore, Anna Sapino, Filippo Pietrantonio, Davide Corà
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 10, Iss 9, Pp n/a-n/a (2018)
EMBO Molecular Medicine, Vol 10, Iss 9, Pp n/a-n/a (2018)
The onset of secondary resistance represents a major limitation to long‐term efficacy of target therapies in cancer patients. Thus, the identification of mechanisms mediating secondary resistance is the key to the rational design of therapeutic str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d54923bf4ca7c091fcb612c468fda6
http://hdl.handle.net/2318/1671637
http://hdl.handle.net/2318/1671637
Autor:
Sergio Anastasi
Publikováno v:
Hepatology. 69:925-925
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6da6cbf6fa94744a0d36c993e378da9e
https://doi.org/10.1002/hep.30502
https://doi.org/10.1002/hep.30502
Autor:
Simona Polo, Oreste Segatto, Giulia Varsano, Stefano Alemà, Loriana Castellani, Elena Maspero, Costanza Ballarò, Yuri Frosi, Sergio Anastasi
Publikováno v:
The Journal of Cell Biology
The EGFR kinase inhibitor RALT/MIG6 also functions as an endocytic adaptor to promote receptor internalization by scaffolding AP-2 and intersectins.
Signaling by epidermal growth factor receptor (EGFR) must be controlled tightly because aberrant
Signaling by epidermal growth factor receptor (EGFR) must be controlled tightly because aberrant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d28d3df4f6f66a8105a0803e86c62f7
https://doi.org/10.1083/jcb.201002032
https://doi.org/10.1083/jcb.201002032
Publikováno v:
Oncogene (Basingstoke) 26 (2007): 7833–7846.
info:cnr-pdr/source/autori:Anastasi S., Baietti M.F., Frosi Y., Alemà S. and Segatto O./titolo:The evolutionarily conserved EBR module of RALT%2FMIG6 mediates suppression of the EGFR catalytic activity/doi:/rivista:Oncogene (Basingstoke)/anno:2007/pagina_da:7833/pagina_a:7846/intervallo_pagine:7833–7846/volume:26
info:cnr-pdr/source/autori:Anastasi S., Baietti M.F., Frosi Y., Alemà S. and Segatto O./titolo:The evolutionarily conserved EBR module of RALT%2FMIG6 mediates suppression of the EGFR catalytic activity/doi:/rivista:Oncogene (Basingstoke)/anno:2007/pagina_da:7833/pagina_a:7846/intervallo_pagine:7833–7846/volume:26
Physiological signalling by the epidermal growth factor receptor (EGFR) controls developmental processes and tissue homeostasis, whereas aberrant EGFR activity drives oncogenic cell transformation. Under normal conditions, the EGFR must therefore gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ccc628863440b37e7139c8d2856094
https://doi.org/10.1038/sj.onc.1210590
https://doi.org/10.1038/sj.onc.1210590