Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Sergio Adamo"'
Autor:
Alessandra Renzini, Nicoletta Marroncelli, Giorgia Cavioli, Silvia Di Francescantonio, Laura Forcina, Alessandro Lambridis, Eros Di Giorgio, Sergio Valente, Antonello Mai, Claudio Brancolini, Claudia Giampietri, Alessandra Magenta, Francesca De Santa, Sergio Adamo, Dario Coletti, Viviana Moresi
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 2, Pp 1339-1359 (2022)
Abstract Background Histone deacetylase 4 (HDAC4) is a stress‐responsive factor that mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles between the nucleus and the cytoplasm; however, HDAC4 cytoplasmic functions ha
Externí odkaz:
https://doaj.org/article/b13dd0516d8141bda44390f624641d8b
Autor:
Eva Pigna, Elena Simonazzi, Krizia Sanna, Krzysztof Marian Bernadzki, Tomek Proszynski, Constantin Heil, Daniela Palacios, Sergio Adamo, Viviana Moresi
Publikováno v:
EBioMedicine, Vol 40, Iss , Pp 717-732 (2019)
Background: Histone deacetylase 4 (HDAC4) has been proposed as a target for Amyotrophic Lateral Sclerosis (ALS) because it mediates nerve-skeletal muscle interaction and since its expression in skeletal muscle correlates with the severity of the dise
Externí odkaz:
https://doaj.org/article/4f0df91a0ba54f9ba7cda7a5a676e4d9
Autor:
Valentina Di Felice, Rosario Barone, Eleonora Trovato, Daniela D’Amico, Filippo Macaluso, Claudia Campanella, Antonella Marino Gammazza, Vera Muccilli, Vincenzo Cunsolo, Patrizia Cancemi, Gabriele Multhoff, Dario Coletti, Sergio Adamo, Felicia Farina, Francesco Cappello
Publikováno v:
Cells, Vol 11, Iss 9, p 1406 (2022)
Currently, no commercially available drugs have the ability to reverse cachexia or counteract muscle wasting and the loss of lean mass. Here, we report the methodology used to develop Physiactisome—a conditioned medium released by heat shock protei
Externí odkaz:
https://doaj.org/article/a6fd71659ea948c09164606318511f7e
Publikováno v:
European Journal of Translational Myology (2020)
The neurohypophyseal hormones vasopressin and oxytocin were invested, in recent years, with novel functions upon striated muscle, regulating its differentiation, trophism, and homeostasis. Recent studies highlight that these hormones not only target
Externí odkaz:
https://doaj.org/article/9c941846bd38421da1fd4255c2746fa7
Autor:
Nicoletta Marroncelli, Marzia Bianchi, Marco Bertin, Silvia Consalvi, Valentina Saccone, Marco De Bardi, Pier Lorenzo Puri, Daniela Palacios, Sergio Adamo, Viviana Moresi
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Skeletal muscle exhibits a high regenerative capacity, mainly due to the ability of satellite cells to replicate and differentiate in response to appropriate stimuli. Epigenetic control is effective at different stages of this process. It ha
Externí odkaz:
https://doaj.org/article/8222ae1687854e2c9eb12bbfa1421b9b
Autor:
Eva Pigna, Alessandra Renzini, Emanuela Greco, Elena Simonazzi, Stefania Fulle, Rosa Mancinelli, Viviana Moresi, Sergio Adamo
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-16 (2018)
Abstract Background Denervation triggers numerous molecular responses in skeletal muscle, including the activation of catabolic pathways and oxidative stress, leading to progressive muscle atrophy. Histone deacetylase 4 (HDAC4) mediates skeletal musc
Externí odkaz:
https://doaj.org/article/503e835243a449b8ac98d928a0ac1f8c
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is a key intracellular mediator of a variety of metabolically relevant hormones and cytokines, including the interleukin-6 (IL-6) family of cytokines. The JAK/STAT
Externí odkaz:
https://doaj.org/article/3864b655fe05409cbab9e567447c655f
Autor:
Alexandra Baccam, Alexandra Benoni-Sviercovich, Marco Rocchi, Viviana Moresi, Marilia Seelaender, Zhenlin Li, Sergio Adamo, Zhigang Xue, Dario Coletti
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Activin negatively affects muscle fibers and progenitor cells in aging (sarcopenia) and in chronic diseases characterized by severe muscle wasting (cachexia). High circulating activin levels predict poor survival in cancer patients. However, the rela
Externí odkaz:
https://doaj.org/article/9a7d89b216c54a50bbd87bdeea3cb6f3
Publikováno v:
Frontiers in Physiology, Vol 9 (2019)
Externí odkaz:
https://doaj.org/article/f72d1d80395c4f74a2369b015a5a4d9f
Autor:
Emanuele Berardi, Luca Madaro, Biliana Lozanoska-Ochser, Sergio Adamo, Lieven Thorrez, Marina Bouche, Dario Coletti
Publikováno v:
Diagnostics, Vol 11, Iss 1, p 116 (2021)
Body weight loss, mostly due to the wasting of skeletal muscle and adipose tissue, is the hallmark of the so-called cachexia syndrome. Cachexia is associated with several acute and chronic disease states such as cancer, chronic obstructive pulmonary
Externí odkaz:
https://doaj.org/article/6b8398d464dd4c4896a4833b634fe082