Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Sergio A. Rodriguez‐Aponte"'
Autor:
Neil C. Dalvie, Timothy R. Lorgeree, Yuchen Yang, Sergio A. Rodriguez-Aponte, Charles A. Whittaker, Joshua A. Hinckley, John J. Clark, Amanda M. Del Rosario, Kerry R. Love, J. Christopher Love
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract Background The yeast Komagataella phaffii is widely used for manufacturing recombinant proteins, but secreted titers of recombinant proteins could be improved by genetic engineering. In this study, we hypothesized that cellular resources cou
Externí odkaz:
https://doaj.org/article/85999b86316148c5b7e4f35b9ac6ca09
Autor:
Neil C. Dalvie, Christopher A. Naranjo, Sergio A. Rodriguez-Aponte, Ryan S. Johnston, J. Christopher Love
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-11 (2022)
Abstract Background Komagataella phaffii is a commonly used alternative host for manufacturing therapeutic proteins, in part because of its ability to secrete recombinant proteins into the extracellular space. Incorrect processing of secreted protein
Externí odkaz:
https://doaj.org/article/fe5f46864deb41008b8adbcc78977c74
Autor:
Gaurav Nagar, Siddharth Jain, Meghraj Rajurkar, Rakesh Lothe, Harish Rao, Sourav Majumdar, Manish Gautam, Sergio A. Rodriguez-Aponte, Laura E. Crowell, J. Christopher Love, Prajakta Dandekar, Amita Puranik, Sunil Gairola, Umesh Shaligram, Ratnesh Jain
Publikováno v:
Vaccines, Vol 11, Iss 10, p 1602 (2023)
SARS-CoV-2 spike protein is an essential component of numerous protein-based vaccines for COVID-19. The receptor-binding domain of this spike protein is a promising antigen with ease of expression in microbial hosts and scalability at comparatively l
Externí odkaz:
https://doaj.org/article/803238a4a29446febff56c33b9a18df2
Autor:
Sakshi Bajoria, Kawaljit Kaur, Ozan S. Kumru, Greta Van Slyke, Jennifer Doering, Hayley Novak, Sergio A. Rodriguez Aponte, Neil C. Dalvie, Christopher A. Naranjo, Ryan S. Johnston, Judith Maxwell Silverman, Harry Kleanthous, J. Christopher Love, Nicholas J. Mantis, Sangeeta B. Joshi, David B. Volkin
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 18, Iss 5 (2022)
Low-cost, refrigerator-stable COVID-19 vaccines will facilitate global access and improve vaccine coverage in low- and middle-income countries. To this end, subunit-based approaches targeting the receptor-binding domain (RBD) of SARS-CoV-2 Spike prot
Externí odkaz:
https://doaj.org/article/35022f23ff944bc2b948e4fb228bed37
RBD-VLP Vaccines Adjuvanted with Alum or SWE Protect K18-hACE2 Mice against SARS-CoV-2 VOC Challenge
Autor:
Ting Y. Wong, Brynnan P. Russ, Katherine S. Lee, Olivia A. Miller, Jason Kang, Melissa Cooper, Michael T. Winters, Sergio A. Rodriguez-Aponte, Neil C. Dalvie, Ryan S. Johnston, Nathaniel A. Rader, Zeriel Y. Wong, Holly A. Cyphert, Ivan Martinez, Umesh Shaligram, Saurabh Batwal, Rakesh Lothe, Rahul Chandrasekaran, Gaurav Nagar, Meghraj Rajurkar, Harish Rao, Justin R. Bevere, Mariette Barbier, J. Christopher Love, F. Heath Damron
Publikováno v:
mSphere, Vol 7, Iss 4 (2022)
ABSTRACT The ongoing COVID-19 pandemic has contributed largely to the global vaccine disparity. Development of protein subunit vaccines can help alleviate shortages of COVID-19 vaccines delivered to low-income countries. Here, we evaluated the effica
Externí odkaz:
https://doaj.org/article/7e59b729158c4ad3a17a90eef5a55568
Autor:
Neil C. Dalvie, Joseph R. Brady, Laura E. Crowell, Mary Kate Tracey, Andrew M. Biedermann, Kawaljit Kaur, John M. Hickey, D. Lee Kristensen, Alexandra D. Bonnyman, Sergio A. Rodriguez-Aponte, Charles A. Whittaker, Marina Bok, Celina Vega, Tarit K. Mukhopadhyay, Sangeeta B. Joshi, David B. Volkin, Viviana Parreño, Kerry R. Love, J. Christopher Love
Publikováno v:
Microbial Cell Factories, Vol 20, Iss 1, Pp 1-14 (2021)
Abstract Background Vaccines comprising recombinant subunit proteins are well-suited to low-cost and high-volume production for global use. The design of manufacturing processes to produce subunit vaccines depends, however, on the inherent biophysica
Externí odkaz:
https://doaj.org/article/41653df3a0e545ec8a33dc49cc46216b
Autor:
Sakshi Bajoria, Ozan S. Kumru, Jennifer Doering, Katherine Berman, Greta Van Slyke, Anneka Prigodich, Sergio A. Rodriguez-Aponte, Harry Kleanthous, J. Christopher Love, Nicholas J. Mantis, Sangeeta B. Joshi, David B. Volkin
Publikováno v:
Vaccines, Vol 11, Iss 6, p 1030 (2023)
Aluminum-salt vaccine adjuvants (alum) are commercially available as micron-sized particles with varying chemical composition and crystallinity. There are reports of enhanced adjuvanticity when the alum’s particle size is reduced to the nanometer r
Externí odkaz:
https://doaj.org/article/343ba8c292fa4103b310f647279e6dea
Autor:
Sergio A. Rodriguez‐Aponte, Christopher A. Naranjo, Ryan S. Johnston, Neil C. Dalvie, Laura E. Crowell, Sakshi Bajoria, Ozan S. Kumru, Sangeeta B. Joshi, David B. Volkin, J. Christopher Love
Publikováno v:
Biotechnology and Bioengineering.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8a61cd6f1594d836a91605f0d7ada5c
https://doi.org/10.1002/bit.28385
https://doi.org/10.1002/bit.28385
Autor:
Kerry R. Love, Andrew M. Biedermann, Isabella R. Gengaro, J. Christopher Love, Sergio A. Rodriguez-Aponte
Publikováno v:
Biotechnology and Bioengineering. 119:59-71
Developing media to sustain cell growth and production is an essential and ongoing activity in bioprocess development. Modifications to media can often address host or product-specific challenges, such as low productivity or poor product quality. For
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b09ba8ec21feb30cc87001c936953bb
https://doi.org/10.1002/bit.27947
https://doi.org/10.1002/bit.27947
Autor:
Sergio A. Rodriguez-Aponte, Neil C. Dalvie, Ting Y. Wong, Ryan S. Johnston, Christopher A. Naranjo, Sakshi Bajoria, Ozan S. Kumru, Kawaljit Kaur, Brynnan P. Russ, Katherine S. Lee, Holly A. Cyphert, Mariette Barbier, Harish D. Rao, Meghraj P. Rajurkar, Rakesh R. Lothe, Umesh S. Shaligram, Saurabh Batwal, Rahul Chandrasekaran, Gaurav Nagar, Harry Kleanthous, Sumi Biswas, Justin R. Bevere, Sangeeta B. Joshi, David B. Volkin, F. Heath Damron, J. Christopher Love
There is a continued need for sarbecovirus vaccines that can be manufactured and distributed in low- and middle-income countries (LMICs). Subunit protein vaccines are manufactured at large scales at low costs, have less stringent temperature requirem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ccf32630a7ae84f2a75bcce081265e
https://doi.org/10.1101/2022.09.14.507842
https://doi.org/10.1101/2022.09.14.507842
