Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function.

Autor: Fernando Aprile-Garcia, Michael W Metzger, Marcelo Paez-Pereda, Herbert Stadler, Matías Acuña, Ana C Liberman, Sergio A Senin, Juan Gerez, Esteban Hoijman, Damian Refojo, Mišo Mitkovski, Markus Panhuysen, Walter Stühmer, Florian Holsboer, Jan M Deussing, Eduardo Arzt

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0151862 (2016)

The P2X7 receptor is a member of the P2X family of ligand-gated ion channels. A single-nucleotide polymorphism leading to a glutamine (Gln) by arginine (Arg) substitution at codon 460 of the purinergic P2X7 receptor (P2X7R) has been associated with m

Externí odkaz: https://doaj.org/article/c7a2c0f6da22409e92bac38cbfde733e

Crosstalk of BMP-4 and RA signaling pathways on Pomc gene regulation in corticotrophs

Autor: Mariana Fuertes, Josefina Rosmino, Leandro Eduardo Nieto, Eduardo Arzt, Sergio A. Senin

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Retinoic acid (RA), an active metabolite of Vitamin A, and bone morphogenetic protein 4 (BMP-4) pathways control the transcription of pro-opiomelanocortin (Pomc), the precursor of ACTH. We describe a novel mechanism by which RA and BMP-4 act together

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5bed11794d262a51272c9be0f6444a
https://jme.bioscientifica.com/view/journals/jme/63/3/JME-19-0059.xml

The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51

Autor: Fernando Aprile-Garcia, Eduardo Arzt, María Antunica-Noguerol, Theo Rein, Florian Holsboer, Maia L. Budziñski, J Druker, Ana C. Liberman, M C Sokn, Nils C. Gassen, Sergio A. Senin

FK506-binding protein 51 (FKBP51) regulates the activity of the glucocorticoid receptor (GR), and is therefore a key mediator of the biological actions of glucocorticoids. However, the understanding of the molecular mechanisms that govern its activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70127f83fbb70df6eff4f748be21eef9
https://www.nature.com/articles/cdd201644

B-Raf and CRHR1 internalization mediate biphasic ERK1/2 activation by CRH in hippocampal HT22 cells

Autor: Eduardo Arzt, Juan José Bonfiglio, Christoph W. Turck, Sergio A. Senin, Damiana Giacomini, Florian Holsboer, Giuseppina Maccarrone, Damian Refojo, Carolina Inda, Susana Silberstein

Publikováno v: Mol. Endocrinol. 2013;27(3):491-510
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

CRH is a key regulator of neuroendocrine, autonomic, and behavioral response to stress. CRH-stimulated CRH receptor 1 (CRHR1) activates ERK1/2 depending on intracellular context. In a previous work, we demonstrated that CRH activates ERK1/2 in limbic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706250b927b8a48ce8bdc9d4fe070de5