Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Sergio, Valente"'
Autor:
Matteo Cassandri, Antonella Porrazzo, Silvia Pomella, Beatrice Noce, Clemens Zwergel, Francesca Antonella Aiello, Francesca Vulcano, Luisa Milazzo, Simona Camero, Deborah Pajalunga, Massimo Spada, Valeria Manzi, Giovanni Luca Gravina, Silvia Codenotti, Michela Piccione, Miriam Tomaciello, Michele Signore, Giovanni Barillari, Cinzia Marchese, Alessandro Fanzani, Biagio De Angelis, Concetta Quintarelli, Christopher R. Vakoc, Eleanor Y. Chen, Francesca Megiorni, Franco Locatelli, Sergio Valente, Antonello Mai, Rossella Rota, Francesco Marampon
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-20 (2024)
Abstract Radiotherapy (RT) plays a critical role in the management of rhabdomyosarcoma (RMS), the prevalent soft tissue sarcoma in childhood. The high risk PAX3-FOXO1 fusion-positive subtype (FP-RMS) is often resistant to RT. We have recently demonst
Externí odkaz:
https://doaj.org/article/d2578a217b0d469480a398078bb622c7
Autor:
Marie Villares, Nelly Lourenço, Ivan Ktorza, Jérémy Berthelet, Aristeidis Panagiotou, Aurélie Richard, Angélique Amo, Yulianna Koziy, Souhila Medjkane, Sergio Valente, Rossella Fioravanti, Catherine Pioche-Durieu, Laurent Lignière, Guillaume Chevreux, Antonello Mai, Jonathan B. Weitzman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Intracellular pathogens develop elaborate mechanisms to survive within the hostile environments of host cells. Theileria parasites infect bovine leukocytes and cause devastating diseases in cattle in developing countries. Theileria spp. have
Externí odkaz:
https://doaj.org/article/af10ac47463d420890df3492e022ad1c
Autor:
Michela Terri, Pilar Sandoval, Giulio Bontempi, Claudia Montaldo, Henar Tomero-Sanz, Valeria de Turris, Flavia Trionfetti, Lucía Pascual-Antón, Irene Clares-Pedrero, Cecilia Battistelli, Sergio Valente, Clemens Zwergel, Antonello Mai, Laura Rosanò, Miguel Ángel del Pozo, Miguel Sánchez-Álvarez, Carlos Cabañas, Marco Tripodi, Manuel López-Cabrera, Raffaele Strippoli
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-24 (2024)
Abstract Background Peritoneal metastasis, which accounts for 85% of all epithelial ovarian carcinoma (EOC) metastases, is a multistep process that requires the establishment of adhesive interactions between cancer cells and the peritoneal membrane.
Externí odkaz:
https://doaj.org/article/c0bff25f461d43e3bfdafed5446dc3a7
Autor:
Flavia Trionfetti, Claudia Montaldo, Ivan Caiello, Giulio Bontempi, Michela Terri, Marta Tiberi, Vanessa Marchant, Alessandro Domenici, Paolo Menè, Marco Cordani, Clemens Zwergel, Giusi Prencipe, Marta Ruiz-Ortega, Sergio Valente, Antonello Mai, Marco Tripodi, Raffaele Strippoli
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Infectious peritonitis is a leading cause of peritoneal functional impairment and a primary factor for therapy discontinuation in peritoneal dialysis (PD) patients. Although bacterial infections are a common cause of peritonitis episodes, emerging ev
Externí odkaz:
https://doaj.org/article/f9646b558a1344f187e41e3deecc332e
Autor:
Michele Aventaggiato, Tania Arcangeli, Enza Vernucci, Federica Barreca, Luigi Sansone, Laura Pellegrini, Elena Pontemezzo, Sergio Valente, Rossella Fioravanti, Matteo Antonio Russo, Antonello Mai, Marco Tafani
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 810 (2024)
Cancer cells modulate their metabolism, creating an acidic microenvironment that, in turn, can favor tumor progression and chemotherapy resistance. Tumor cells adopt strategies to survive a drop in extracellular pH (pHe). In the present manuscript, w
Externí odkaz:
https://doaj.org/article/870ea823724141e3aba48739c49b7c86
Autor:
Flavia Trionfetti, Tonino Alonzi, Giulio Bontempi, Michela Terri, Cecilia Battistelli, Claudia Montaldo, Federica Repele, Dante Rotili, Sergio Valente, Clemens Zwergel, Giulia Matusali, Fabrizio Maggi, Delia Goletti, Marco Tripodi, Antonello Mai, Raffaele Strippoli
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
BackgroundDespite the significant progress achieved in understanding the pathology and clinical management of SARS-CoV-2 infection, still pathogenic and clinical issues need to be clarified. Treatment with modulators of epigenetic targets, i.e., epid
Externí odkaz:
https://doaj.org/article/31d5bba3c72849e2ab6a5faf175fe1bc
Autor:
Rossella Fioravanti, Veronica Rodriguez, Jonatan Caroli, Ugo Chianese, Rosaria Benedetti, Elisabetta Di Bello, Beatrice Noce, Clemens Zwergel, Davide Corinti, Dolores Viña, Lucia Altucci, Andrea Mattevi, Sergio Valente, Antonello Mai
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 973-985 (2022)
As regioisomers/bioisosteres of 1a, a 4-phenylbenzamide tranylcypromine (TCP) derivative previously disclosed by us, we report here the synthesis and biological evaluation of some (hetero)arylbenzoylamino TCP derivatives 1b-6, in which the 4-phenyl m
Externí odkaz:
https://doaj.org/article/93fcd4f9950b49e69e71b43501b4fcde
Autor:
Giulio Bontempi, Michela Terri, Sabrina Garbo, Claudia Montaldo, Davide Mariotti, Veronica Bordoni, Sergio Valente, Clemens Zwergel, Antonello Mai, Alessandra Marchetti, Alessandro Domenici, Paolo Menè, Cecilia Battistelli, Marco Tripodi, Raffaele Strippoli
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-14 (2022)
Abstract Histone acetylation/deacetylation play an essential role in modifying chromatin structure and in regulating cell plasticity in eukaryotic cells. Therefore, histone deacetylase (HDAC) pharmacological inhibitors are promising tools in the ther
Externí odkaz:
https://doaj.org/article/4ea5b060a1634e27aad97db27700af5b
Autor:
Giulia Stazi, Ludovica Taglieri, Alice Nicolai, Annalisa Romanelli, Rossella Fioravanti, Stefania Morrone, Manuela Sabatino, Rino Ragno, Samanta Taurone, Marcella Nebbioso, Raffaella Carletti, Marco Artico, Sergio Valente, Susanna Scarpa, Antonello Mai
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/893e76ca84e042c89d1c43513000141b
Autor:
Alessandra Renzini, Nicoletta Marroncelli, Giorgia Cavioli, Silvia Di Francescantonio, Laura Forcina, Alessandro Lambridis, Eros Di Giorgio, Sergio Valente, Antonello Mai, Claudio Brancolini, Claudia Giampietri, Alessandra Magenta, Francesca De Santa, Sergio Adamo, Dario Coletti, Viviana Moresi
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 2, Pp 1339-1359 (2022)
Abstract Background Histone deacetylase 4 (HDAC4) is a stress‐responsive factor that mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles between the nucleus and the cytoplasm; however, HDAC4 cytoplasmic functions ha
Externí odkaz:
https://doaj.org/article/b13dd0516d8141bda44390f624641d8b