Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Sergio, Altamura"'
Autor:
Cristiana Lalli, Alessandra Guidi, Nadia Gennari, Sergio Altamura, Alberto Bresciani, Giovina Ruberti
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e0003484 (2015)
Schistosomiasis, one of the world's greatest neglected tropical diseases, is responsible for over 280,000 human deaths per annum. Praziquantel, developed in the 1970s, has high efficacy, excellent tolerability, few and transient side effects, simple
Externí odkaz:
https://doaj.org/article/7c1546abac3041a693a6dedb91c45ed7
Autor:
Barbara Attenni, Salvatore Avolio, Stefania Colarusso, Savina Malancona, Steven Harper, Sergio Altamura, Uwe Koch, Frank Narjes
Publikováno v:
ARKIVOC, Vol 2006, Iss 7, Pp 479-495 (2006)
Externí odkaz:
https://doaj.org/article/6fd050884f1a467ca80c8d6a6e846ba6
Autor:
Daniel O. Cicero, Elisabetta Bianchi, Leticia Toledo-Sherman, Ignacio Munoz-Sanjuan, Paola Fezzardi, Licia Tomei, Robert Pacifici, Alessia Santoprete, Alberto Bresciani, Celia Dominguez, Antonino Missineo, Larry Park, Raffaele Ingenito, Mauro Cerretani, Sergio Altamura, Steven J. Harper, Mariana Gallo
Publikováno v:
Archives of Biochemistry and Biophysics. 631:31-41
Mechanisms that activate innate antioxidant responses, as a way to mitigate oxidative stress at the site of action, hold much therapeutic potential in diseases, such as Parkinson's disease, Alzheimer's disease and Huntington's disease, where the use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23111e296eb4dd845228e78fe4f9832e
https://doi.org/10.1016/j.abb.2017.08.003
https://doi.org/10.1016/j.abb.2017.08.003
Autor:
Nadia Gennari, Emanuela Nizi, Steven J. Harper, Savina Malancona, Sergio Altamura, Edith Monteagudo, David Roberts, Ilaria Biancofiore, Paul Willis, Maria Vittoria Orsale, Ottavia Cecchetti, Antonella Cellucci, Ralph Laufer, Rita Graziani, Alberto Bresciani, Simona Ponzi, Jesus Maria Ontoria Ontoria, Maria Veneziano, Annalise Di Marco, Giacomo Paonessa, Vincenzo Summa, Federica Ferrigno
Publikováno v:
ACS medicinal chemistry letters. 7(5)
The identification of a new series of P. falciparum growth inhibitors is described. Starting from a series of known human class I HDAC inhibitors a SAR exploration based on growth inhibitory activity in parasite and human cells-based assays led to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd9996399049eb56ee09a08a1c03acc
https://pubmed.ncbi.nlm.nih.gov/27190592
https://pubmed.ncbi.nlm.nih.gov/27190592
Autor:
Matteo Andreini, Antonino Missineo, Alberto Bresciani, Paolo Visca, Sergio Altamura, Daniela Visaggio, Lorenzo Turcano, Emanuela Frangipani
Publikováno v:
SLAS discovery : advancing life sciences RD. 22(7)
Pseudomonas infections are common among hospitalized, immunocompromised, and chronic lung disease patients. These infections are recalcitrant to common antibacterial therapies due to inherent antibiotic resistance. To meet the need of new anti- Pseud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e24a57ef14fc36b421d798e13737198
https://pubmed.ncbi.nlm.nih.gov/28346095
https://pubmed.ncbi.nlm.nih.gov/28346095
Autor:
Sergio Altamura, Antonio Baldini, Monica Bisbocci, Gabriella Lania, Vincenza Colonna, Alberto Bresciani, Alessandra Francone
Publikováno v:
Scopus-Elsevier
Human Molecular Genetics
Human molecular genetics
(2017). doi:10.1093/hmg/ddx353
info:cnr-pdr/source/autori:Lania G, Bresciani A, Bisbocci M, Francone A, Colonna V, Altamura S, Baldini A./titolo:Vitamin B12 ameliorates the phenotype of a mouse model of DiGeorge syndrome./doi:10.1093%2Fhmg%2Fddx353/rivista:Human molecular genetics (Print)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume
25 (2016): 4369–4375. doi:10.1093/hmg/ddw267
info:cnr-pdr/source/autori:Lania G, Bresciani A, Bisbocci M, Francone A, Colonna V, Altamura S, Baldini A./titolo:Vitamin B12 ameliorates the phenotype of a mouse model of DiGeorge syndrome./doi:10.1093%2Fhmg%2Fddw267/rivista:Human molecular genetics (Print)/anno:2016/pagina_da:4369/pagina_a:4375/intervallo_pagine:4369–4375/volume:25
Human Molecular Genetics
Human molecular genetics
(2017). doi:10.1093/hmg/ddx353
info:cnr-pdr/source/autori:Lania G, Bresciani A, Bisbocci M, Francone A, Colonna V, Altamura S, Baldini A./titolo:Vitamin B12 ameliorates the phenotype of a mouse model of DiGeorge syndrome./doi:10.1093%2Fhmg%2Fddx353/rivista:Human molecular genetics (Print)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume
25 (2016): 4369–4375. doi:10.1093/hmg/ddw267
info:cnr-pdr/source/autori:Lania G, Bresciani A, Bisbocci M, Francone A, Colonna V, Altamura S, Baldini A./titolo:Vitamin B12 ameliorates the phenotype of a mouse model of DiGeorge syndrome./doi:10.1093%2Fhmg%2Fddw267/rivista:Human molecular genetics (Print)/anno:2016/pagina_da:4369/pagina_a:4375/intervallo_pagine:4369–4375/volume:25
Pathological conditions caused by reduced dosage of a gene, such as gene haploinsufficiency, can potentially be reverted by enhancing the expression of the functional allele. In practice, low specificity of therapeutic agents, or their toxicity reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65403d77703fedaac64046b8d33dc720
http://hdl.handle.net/11588/643539
http://hdl.handle.net/11588/643539
Autor:
Cristina Gardelli, Uwe Koch, Odalys Gonzalez-Paz, Barbara Pacini, Claudio Giuliano, Renzo Bazzo, Vincenzo Pucci, Joseph F. Leone, Kenneth A. Koeplinger, Michael Rowley, Frank Narjes, Sergio Altamura, Fabrizio Fiore, Malte Meppen, Ralph Laufer, Annalise Di Marco
Publikováno v:
European Journal of Medicinal Chemistry. 44:3765-3770
The currently approved treatment for hepatitis C virus infections is a combination of Ribavirin and pegylated Interferon. It leads to a sustained virologic response in approximately only half of the patients treated. For this reason there is an urgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93077b6796954614acb74a771114aabe
https://doi.org/10.1016/j.ejmech.2009.04.043
https://doi.org/10.1016/j.ejmech.2009.04.043
Autor:
Sergio Altamura, Giacomo Paonessa, Andrea Carfi, Marco Mattu, Linda Bartholomew, Giovanni Migliaccio, Antonella Cellucci, Raffaele De Francesco, Donald J. Graham, Steven W. Ludmerer, Gaetano Barbato, Edwin H. Rydberg
Publikováno v:
Journal of Molecular Biology. 390:1048-1059
Hepatitis C virus (HCV) exists in six major genotypes. Compared with the 1b enzyme, genotype 2b HCV polymerase exhibits a more than 100-fold reduction in sensitivity to the indole-N-acetamide class of non-nucleoside inhibitors. These compounds have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b94af0e7580d2caf7f29dabea8a221
https://doi.org/10.1016/j.jmb.2009.06.012
https://doi.org/10.1016/j.jmb.2009.06.012
Autor:
Caterina Ercolani, Frank Narjes, Ian Stansfield, Michael Rowley, Sergio Altamura, Uwe Koch, Claudio Giuliano, Giovanni Migliaccio, Raffaele De Francesco, Petra Neddermann, Immacolata Conte
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1779-1783
The RNA replication machinery of HCV is a multi-subunit membrane–associated complex. NS5A has emerged as an active component of HCV replicase, possibly involved in regulation of viral replication and resistance to the antiviral effect of interferon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa29c92a3fb0da018a48ef24b2764ec7
https://doi.org/10.1016/j.bmcl.2009.01.066
https://doi.org/10.1016/j.bmcl.2009.01.066
Autor:
Francesca Salvatori, Ilaria Lampronti, Igea Accardo, Alex Manicardi, Roberto Gambari, Giulia Montagner, Enrica Fabbri, Alessia Finotti, Chiara Gemmo, Monica Borgatti, Sergio Altamura, Giulia Breveglieri, Alberto Bresciani, Nicoletta Bianchi, Roberto Corradini
Publikováno v:
International Journal of Molecular Medicine
In the treatment of hemoglobinopathies, amending altered hemoglobins and/or globins produced in excess is an important part of therapeutic strategies and the selective inhibition of globin production may be clinically beneficial. Therefore the develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b7bb116cb2e7fc0293a950fd3bc0dc
http://hdl.handle.net/11392/2292621
http://hdl.handle.net/11392/2292621