Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sergii Krysenko"'
Autor:
Sergii Krysenko, Wolfgang Wohlleben
Publikováno v:
Microorganisms, Vol 12, Iss 8, p 1571 (2024)
The natural soil environment of Streptomyces is characterized by variations in the availability of nitrogen, carbon, phosphate and sulfur, leading to complex primary and secondary metabolisms. Their remarkable ability to adapt to fluctuating nutrient
Externí odkaz:
https://doaj.org/article/252e4cf7cb1744a5a875a0e249a1fc91
Autor:
Susann Schulz, Christoph Schall, Thilo Stehle, Christian Breitmeyer, Sergii Krysenko, Agnieszka Mitulski, Wolfgang Wohlleben
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Tacrolimus (FK506) is a macrolide widely used as immunosuppressant to prevent transplant rejection. Synthetic production of FK506 is not efficient and costly, whereas the biosynthesis of FK506 is complex and the level produced by the wild type strain
Externí odkaz:
https://doaj.org/article/096f27afd2ae4dfd99fa4e7826c58555
Autor:
Sergii Krysenko, Wolfgang Wohlleben
Publikováno v:
Medical Sciences, Vol 10, Iss 3, p 40 (2022)
Nitrogen is an essential element required for bacterial growth. It serves as a building block for the biosynthesis of macromolecules and provides precursors for secondary metabolites. Bacteria have developed the ability to use various nitrogen source
Externí odkaz:
https://doaj.org/article/373ff41aa97446afb296c4e2218f9b4a
Autor:
Sergii Krysenko, Arne Matthews, Nicole Okoniewski, Andreas Kulik, Melis G. Girbas, Olga Tsypik, Christian Stephan Meyners, Felix Hausch, Wolfgang Wohlleben, Agnieszka Bera
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Streptomyces coelicolor is a Gram-positive soil bacterium with a high metabolic and adaptive potential that is able to utilize a variety of nitrogen sources. However, little is known about the utilization of the alternative nitrogen source e
Externí odkaz:
https://doaj.org/article/01dd08b98bc744a2b1d7d75139ece7d2
Autor:
Agnieszka Bera, Sergii Krysenko, Nicole Okoniewski, Andreas Kulik, Arne Matthews, Jan Grimpo, Wolfgang Wohlleben
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Streptomyces coelicolor M145 was shown to be able to grow in the presence of high concentrations of polyamines, such as putrescine, cadaverine, spermidine, or spermine, as a sole nitrogen source. However, hardly anything is known about polyamine util
Externí odkaz:
https://doaj.org/article/0311c4045bb04e579ac3b975364c923f
Autor:
Rafat Amin, Mirita Franz-Wachtel, Yvonne Tiffert, Martin Heberer, Mohamed Meky, Yousra Ahmed, Arne Matthews, Sergii Krysenko, Marco Jakobi, Markus Hinder, Jane Moore, Nicole Okoniewski, Boris Macek, Wolfgang Wohlleben, Agnieszka Bera
Publikováno v:
Frontiers in Molecular Biosciences, Vol 3 (2016)
Soil-dwelling Streptomyces bacteria such as S. coelicolor have to constantly adapt to the nitrogen (N) availability in their habitat. Thus, strict transcriptional and post-translational control of the N-assimilation is fundamental for survival of thi
Externí odkaz:
https://doaj.org/article/438fec285f9c46f286eb64a723334808
Autor:
Susann Schulz, Håvard Sletta, Kristin Fløgstad Degnes, Sergii Krysenko, Alicia Williams, Silje Malene Olsen, Kai Vernstad, Agnieszka Mitulski, Wolfgang Wohlleben
Publikováno v:
Applied Microbiology and Biotechnology. 107:2871-2886
Abstract FK-506 is a potent immunosuppressive macrocyclic polyketide with growing pharmaceutical interest, produced by Streptomyces tsukubaensis. However, due to low levels synthesized by the wild-type strain, biotechnological production of FK-506 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e1229799a891dabbd97487f67098f69
https://doi.org/10.1007/s00253-023-12473-9
https://doi.org/10.1007/s00253-023-12473-9
Autor:
Sergii Krysenko, Wolfgang Wohlleben
Publikováno v:
BIOspektrum. 28:23-26
Streptomycetes have to cope with fluctuating nitrogen conditions in soil. Key enzymes in nitrogen metabolism in streptomycetes are the two glutamine synthetases (GSs), GlnA and GlnII. We demonstrated that GlnA3 and GlnA4, proteins previously annotate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21e44977d9ac8e89e7645028129efdd8
https://doi.org/10.1007/s12268-022-1685-x
https://doi.org/10.1007/s12268-022-1685-x
Autor:
Patrick L. Purder, Christian Meyners, Sergii Krysenko, Jonathan Funk, Wolfgang Wohlleben, Felix Hausch
Publikováno v:
Chembiochem : a European journal of chemical biology. 23(19)
γ‐Glutamylamine synthetases are an important class of enzymes that play a key role in glutamate‐based metabolism. Methionine sulfoximine (MSO) is a well‐established inhibitor for the archetypal glutamine synthetase (GS) but inhibitors for most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8278e439e02fcf3366deb513f86a69
https://pubmed.ncbi.nlm.nih.gov/35976722
https://pubmed.ncbi.nlm.nih.gov/35976722
Publikováno v:
Microbial Physiology. 31:233-247
Soil bacteria from the genus Streptomyces, phylum Actinobacteria, feature a complex metabolism and diverse adaptations to environmental stress. These characteristics are consequences of variable nutrition availability in the soil and allow survival u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f32467ad05d0ae23e49704db481cfd2
https://doi.org/10.1159/000516644
https://doi.org/10.1159/000516644