Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sergii Gladchuk"'
Autor:
Pei Meng, Hina Dalal, Yilun Chen, Christian Brueffer, Sergii Gladchuk, Miguel Alcaide, Anna Ehinger, Lao H. Saal
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract HER2/ERBB2 evaluation is necessary for treatment decision-making in breast cancer (BC), however current methods have limitations and considerable variability exists. DNA copy number (CN) evaluation by droplet digital PCR (ddPCR) has compleme
Externí odkaz:
https://doaj.org/article/f860143035084445832901bac01327da
Autor:
Hina Dalal, Malin Dahlgren, Sergii Gladchuk, Christian Brueffer, Sofia K. Gruvberger-Saal, Lao H. Saal
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Estrogen receptor alpha (ERα, encoded by ESR1) is a well-characterized transcription factor expressed in more than 75% of breast tumors and is the key biomarker to direct endocrine therapies. On the other hand, much less is known about estr
Externí odkaz:
https://doaj.org/article/d4846f6f066d4b8e98d670e12b1413cf
Autor:
Christian Brueffer, Sergii Gladchuk, Christof Winter, Johan Vallon‐Christersson, Cecilia Hegardt, Jari Häkkinen, Anthony M George, Yilun Chen, Anna Ehinger, Christer Larsson, Niklas Loman, Martin Malmberg, Lisa Rydén, Åke Borg, Lao H Saal
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp n/a-n/a (2020)
Abstract Breast cancer is a disease of genomic alterations, of which the panorama of somatic mutations and how these relate to subtypes and therapy response is incompletely understood. Within SCAN‐B (ClinicalTrials.gov: NCT02306096), a prospective
Externí odkaz:
https://doaj.org/article/36861d41d6c2406c82e4c1a71682a95f
Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer
Autor:
Malin, Dahlgren, Anthony M, George, Christian, Brueffer, Sergii, Gladchuk, Yilun, Chen, Johan, Vallon-Christersson, Cecilia, Hegardt, Jari, Häkkinen, Lisa, Rydén, Martin, Malmberg, Christer, Larsson, Sofia K, Gruvberger-Saal, Anna, Ehinger, Niklas, Loman, Åke, Borg, Lao H, Saal
Publikováno v:
JNCI Cancer Spectrum
Background More than three-quarters of primary breast cancers are positive for estrogen receptor alpha (ER; encoded by the gene ESR1), the most important factor for directing anti-estrogenic endocrine therapy (ET). Recently, mutations in ESR1 were id
Autor:
Jari Häkkinen, Cecilia Hegardt, Niklas Loman, Johan Vallon-Christersson, Lisa Rydén, Anthony M. George, Christian Brueffer, Christer Larsson, Lao H. Saal, Christof Winter, Sergii Gladchuk, Martin Malmberg, Yilun Chen, Åke Borg, Anna Ehinger
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 10, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 10, Pp n/a-n/a (2020)
Breast cancer is a disease of genomic alterations, of which the panorama of somatic mutations and how these relate to subtypes and therapy response is incompletely understood. Within SCAN‐B (ClinicalTrials.gov: NCT02306096), a prospective study elu
Autor:
Lao H. Saal, Jari Häkkinen, Christer Larsson, Cecilia Hegardt, Anna Ehinger, Sofia Gruvberger, Malin Dahlgren, Christian Brueffer, Anthony M. George, Johan Vallon-Christersson, Åke Borg, Sergii Gladchuk, Martin Malmberg, Yilun Chen, Niklas Loman, Lisa Rydén
Publikováno v:
Cancer Research. 80:CT074-CT074
Background: More than three-quarters of primary breast cancers are positive for estrogen receptor alpha (ER; encoded by the gene ESR1), the most important factor for directing anti-estrogenic endocrine therapy. Although mutation in ESR1 is known as a
Autor:
Lao H. Saal, Niklas Loman, Christian Brueffer, Christof Winter, Cecilia Hegardt, Christer Larsson, Åke Borg, Johan Vallon-Christersson, Anna Ehinger, Anthony M. George, Lisa Rydén, Sergii Gladchuk, Jari Häkkinen, Martin Malmberg, Yilun Chen
Publikováno v:
Journal of Clinical Oncology. 38:518-518
518 Background: Breast cancer is a disease of genomic alterations, of which the complete panorama of somatic mutations and how these relate to molecular subtypes and therapy response is incompletely understood. The Sweden Cancerome Analysis Network-B