Differential toxicity profile of secreted and processed α-Klotho expression over mineral metabolism and bone microstructure

Autor: Joan Roig-Soriano, Cristina Sánchez-de-Diego, Jon Esandi-Jauregui, Sergi Verdés, Carmela R. Abraham, Assumpció Bosch, Francesc Ventura, Miguel Chillón

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract The aging-protective gene α-Klotho (KL) produces two main transcripts. The full-length mRNA generates a transmembrane protein that after proteolytic ectodomain shedding can be detected in serum as processed Klotho (p-KL), and a shorter tran

Externí odkaz: https://doaj.org/article/6d0e213469a84004ae0d9ef85a56bf58

Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1G93A ALS Mice

Autor: Guillem Mòdol-Caballero, Mireia Herrando-Grabulosa, Sergi Verdés, Belén García-Lareu, Neus Hernández, Isaac Francos-Quijorna, Rubén López-Vales, Assumpció Bosch, Xavier Navarro

Publikováno v: Frontiers in Neurology, Vol 12 (2021)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting the neuromuscular system for which currently there is no effective therapy. Motoneuron (MN) degeneration involves several complex mechanisms, including surrounding gli

Externí odkaz: https://doaj.org/article/de3aa861366a46a9a56f3e37e6182c97

Therapeutic Role of Neuregulin 1 Type III in SOD1-Linked Amyotrophic Lateral Sclerosis

Autor: Mireia Herrando-Grabulosa, Xavier Navarro, Assumpció Bosch, Guillem Mòdol-Caballero, Lorena Ariza, Frédéric Brocard, Irene Sanchez-Brualla, Belén García-Lareu, Sergi Verdés

Publikováno v: Neurotherapeutics
Neurotherapeutics, 2020, 17 (3), pp.1048-1060. ⟨10.1007/s13311-019-00811-7⟩
Neurotherapeutics, Springer Verlag, 2020, 17 (3), pp.1048-1060. ⟨10.1007/s13311-019-00811-7⟩

Amyotrophic lateral sclerosis (ALS) is a devastating motoneuron (Mn) disease without effective cure currently available. Death of MNs in ALS is preceded by failure of neuromuscular junctions and axonal retraction. Neuregulin 1 (NRG1) is a neurotrophi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32408e3870617813efe423e41268b117
https://doi.org/10.1007/s13311-019-00811-7

Specific Expression of Glial-Derived Neurotrophic Factor in Muscles as Gene Therapy Strategy for Amyotrophic Lateral Sclerosis

Autor: Belén García-Lareu, Assumpció Bosch, Rubèn López-Vales, Xavier Navarro, Sergi Verdés, Miguel Chillón, Gemma Pagès, Mireia Herrando-Grabulosa, Guillem Mòdol-Caballero

Publikováno v: Neurotherapeutics

Glial cell line–derived neurotrophic factor (GDNF) is a powerful neuroprotective growth factor. However, systemic or intrathecal administration of GDNF is associated with side effects. Here, we aimed to avoid this by restricting the transgene expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a20c5886138274dbec136fc5778985
https://pubmed.ncbi.nlm.nih.gov/33786805

Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1 G93AALS Mice

Autor: Guillem Mòdol-Caballero, Mireia Herrando-Grabulosa, Sergi Verdés, Belén García-Lareu, Neus Hernández, Isaac Francos-Quijorna, Rubén López-Vales, Assumpció Bosch, Xavier Navarro

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientia
Frontiers in Neurology, Vol 12 (2021)
Frontiers in Neurology

Motoneuron; Neuregulin 1; Spinal cord Motoneurona; Neuregulina 1; Médula espinal Motoneurona; Neuregulina 1; Medul·la espinal Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting the neuromuscular system for which curr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e3a5a6011ede7f3bc47683f7f0d90c
https://ddd.uab.cat/record/267003