HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels.

Autor: Miguel López-Dupla, Elsa Maymó-Masip, Esteban Martínez, Pere Domingo, Manuel Leal, Joaquim Peraire, Consuelo Viladés, Sergi Veloso, Mireia Arnedo, Sara Ferrando-Martínez, Raúl Beltrán-Debón, Verónica Alba, Josep Ma Gatell, Joan Vendrell, Francesc Vidal, Matilde R Chacón

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144789 (2015)

BACKGROUND AND OBJECTIVES:Obesity and HIV-1/HAART-associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an

Externí odkaz: https://doaj.org/article/17ffd967858d48e889e877a65311a2cf

Glutaminolysis and lipoproteins are key factors in late immune recovery in successfully treated HIV-infected patients

Autor: Enrique Bernal, Julià Blanco, Esther Rodríguez-Gallego, Manuel Leal, Félix Gutiérrez, Isaac Rosado-Sánchez, Pol Herrero, Fran Fanjul, Ricardo Pelazas, Francesc Vidal, Anna Rull, Miguel López-Dupla, Consuelo Viladés, Joaquim Peraire, Yolanda M. Pacheco, Sergi Veloso

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

The immunological, biochemical and molecular mechanisms associated with poor immune recovery are far from known, and metabolomic profiling offers additional value to traditional soluble markers. Here, we present novel and relevant data that could con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5e2bedbe1ddcf6e3410da7fad12371
https://doi.org/10.1042/cs20190111

High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients

Autor: Laia Reverté, Francesc Vidal, Andra Ceausu, Josep Mallolas, Carles Perpiñán, Alexy Inciarte, Jenifer Masip, Sergi Veloso, Verónica Alba, Pere Domingo, Judit Vidal-Gonzalez, Joaquim Peraire, Yolanda M. Pacheco, Anna Rull, Elena Yeregui, Montserrat Vargas, Anna Martí, Vicenç Falcó, Consuelo Viladés, Maria Peraire

Publikováno v: EBioMedicine
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
r-IIB SANT PAU: Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
EBioMedicine, Vol 62, Iss, Pp 103077-(2020)

© 2020 The Authors.
[Background]: The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4+ T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865c1c70fcaaf482bb32fd38da3c5dfb
https://pubmed.ncbi.nlm.nih.gov/33166788

A baseline metabolomic signature is associated with immunological CD4+ T-cell recovery after 36 months of antiretroviral therapy in HIV-infected patients

Autor: Roger Mallol, Xavier Correig, Manuel Leal, Yolanda M. Pacheco, Anna Rull, Nicolau Cañellas, Verónica Alba, Consuelo Viladés, Francesc Vidal, Esther Rodríguez-Gallego, Miguel López-Dupla, Raúl Beltrán-Debón, Joaquim Peraire, Sergi Veloso, Pere Domingo, Josep Gómez, Julià Blanco

Publikováno v: AIDS (London, England)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
AIDS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol

Altres ajuts: GLD13/00168 Altres ajuts: GLD14/293 Altres ajuts: PERIS/SLT002-16-00101 Poor immunological recovery in treated HIV-infected patients is associated with greater morbidity and mortality. To date, predictive biomarkers of this incomplete i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a60b062cfdb30d1e1acbc656d5166a6
http://europepmc.org/articles/PMC5844590

Leptin and adiponectin, but not IL18, are related with insulin resistance in treated HIV-1-infected patients with lipodystrophy

Autor: Xavier Escoté, Joaquim Peraire, Antoni Castro, Manuel Leal, Sergi Veloso, Pere Domingo, Consuelo Viladés, Victoria Ceperuelo-Mallafré, Miguel López-Dupla, Francesc Vidal, Joan-Josep Sirvent, Joan Vendrell, Cristóbal Richart, Montserrat Olona

Publikováno v: CYTOKINE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Instituto de Salud Carlos III (ISCIII)

Leptin, adiponectin and IL18 are adipokines related with obesity, insulin resistance and dyslipidemia in the general population. Treated HIV-1-infected patients with lipodystrophy may develop insulin resistance and proatherogenic dyslipidemia. We ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd5e7dc7b3233d0e58c129c79a828ea
https://doi.org/10.1016/j.cyto.2012.01.013