Exploring the RNase A scaffold to combine catalytic and antimicrobial activities. Structural characterization of RNase 3/1 chimeras

Autor: Pablo Fernández-Millán, Sergi Vázquez-Monteagudo, Ester Boix, Guillem Prats-Ejarque

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

Design of novel antibiotics to fight antimicrobial resistance is one of the first global health priorities. Novel protein-based strategies come out as alternative therapies. Based on the structure-function knowledge of the RNase A superfamily we have

Externí odkaz: https://doaj.org/article/4a5b2b93fb574fb381e6e1dce4ed1812

Structure-Based Design of an RNase Chimera for Antimicrobial Therapy

Autor: Guillem Prats-Ejarque, Helena Lorente, Clara Villalba, Raúl Anguita, Lu Lu, Sergi Vázquez-Monteagudo, Pablo Fernández-Millán, Ester Boix

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 95, p 95 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 95
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Altres ajuts: Fundació La Marató de TV3/TV3-201803-10 Bacterial resistance to antibiotics urges the development of alternative therapies. Based on the structure-function of antimicrobial members of the RNase A superfamily, we have developed a hybri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c0db414e4e45b966a61003ff7a3ae2
https://www.mdpi.com/1422-0067/23/1/95