Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sergi Guixé-Muntet"'
Autor:
Radhika Joshi, Veronika Brezani, Gabrielle M. Mey, Sergi Guixé-Muntet, Marti Ortega-Ribera, Yuan Zhuang, Adam Zivny, Sebastian Werneburg, Jordi Gracia-Sancho, Gyongyi Szabo
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract The pathological role of interferon signaling is emerging in neuroinflammatory disorders, yet, the specific role of Interferon Regulatory Factor 3 (IRF3) in neuroinflammation remains poorly understood. Here, we show that global IRF3 deficien
Externí odkaz:
https://doaj.org/article/a6777c870b7d4b4d97a8c4e5b7383a1a
Autor:
Kang Zheng, Fengjie Hao, Sandra Medrano-Garcia, Chaobo Chen, Feifei Guo, Laura Morán-Blanco, Sandra Rodríguez-Perales, Raúl Torres-Ruiz, María Isabel Peligros, Javier Vaquero, Rafael Bañares, Manuel Gómez del Moral, José R. Regueiro, Eduardo Martínez-Naves, Mohamed Ramadan Mohamed, Rocío Gallego-Durán, Douglas Maya, Javier Ampuero, Manuel Romero-Gómez, Albert Gilbert-Ramos, Sergi Guixé-Muntet, Anabel Fernández-Iglesias, Jordi Gracia-Sancho, Mar Coll, Isabel Graupera, Pere Ginès, Andreea Ciudin, Jesús Rivera-Esteban, Juan M. Pericàs, María Dolores Frutos, Bruno Ramos Molina, José María Herranz, Matías A. Ávila, Yulia A. Nevzorova, Edgar Fernández-Malavé, Francisco Javier Cubero
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-12 (2023)
Abstract Progressive hepatic damage and fibrosis are major features of chronic liver diseases of different etiology, yet the underlying molecular mechanisms remain to be fully defined. N-RAS, a member of the RAS family of small guanine nucleotide-bin
Externí odkaz:
https://doaj.org/article/01a591f664c741c59cc9c983321052fd
Autor:
Eric Felli, Sonia Selicean, Sergi Guixé-Muntet, Cong Wang, Jaume Bosch, Annalisa Berzigotti, Jordi Gracia-Sancho
Publikováno v:
JHEP Reports, Vol 5, Iss 11, Pp 100869- (2023)
Summary: The interplay between mechanical stimuli and cellular mechanobiology orchestrates the physiology of tissues and organs in a dynamic balance characterized by constant remodelling and adaptative processes. Environmental mechanical properties c
Externí odkaz:
https://doaj.org/article/e7268437beb74121a264f4a0f32d53a0
Autor:
Jordi Gracia‐Sancho, Nicolò Manicardi, Martí Ortega‐Ribera, Raquel Maeso‐Díaz, Sergi Guixé‐Muntet, Anabel Fernández‐Iglesias, Diana Hide, Héctor García‐Calderó, Zoe Boyer‐Díaz, Patricia C. Contreras, Alfred Spada, Jaime Bosch
Publikováno v:
Hepatology Communications, Vol 3, Iss 7, Pp 987-1000 (2019)
In cirrhosis, liver microvascular dysfunction is a key factor increasing hepatic vascular resistance to portal blood flow, which leads to portal hypertension. De‐regulated inflammatory and pro‐apoptotic processes due to chronic injury play import
Externí odkaz:
https://doaj.org/article/5e9aa8e0b22b4f6ab1c1ba7332d46118
Autor:
Sergi Guixé-Muntet, Martí Ortega-Ribera, Cong Wang, Sonia Selicean, Ion Andreu, Jenny Z. Kechagia, Constantino Fondevila, Pere Roca-Cusachs, Jean-François Dufour, Jaime Bosch, Annalisa Berzigotti, Jordi Gracia-Sancho
Publikováno v:
JHEP Reports, Vol 2, Iss 5, Pp 100145- (2020)
Background & Aims: Liver stiffness is increased in advanced chronic liver disease (ACLD) and accurately predicts prognosis in this population. Recent data suggest that extracellular matrix stiffness per se may modulate the phenotype of liver cells. W
Externí odkaz:
https://doaj.org/article/5cbdcdbe08844848a5d130ec84778d74
Autor:
Albert Gibert-Ramos, David Sanfeliu-Redondo, Peio Aristu-Zabalza, Ana Martínez-Alcocer, Jordi Gracia-Sancho, Sergi Guixé-Muntet, Anabel Fernández-Iglesias
Publikováno v:
Cancers, Vol 13, Iss 22, p 5719 (2021)
The liver sinusoids are a unique type of microvascular beds. The specialized phenotype of sinusoidal cells is essential for their communication, and for the function of all hepatic cell types, including hepatocytes. Liver sinusoidal endothelial cells
Externí odkaz:
https://doaj.org/article/82e69200b4194c729f1fdff4d3c56886
Autor:
Fernanda Cristina de Mesquita, Sergi Guixé-Muntet, Anabel Fernández-Iglesias, Raquel Maeso-Díaz, Sergi Vila, Diana Hide, Martí Ortega-Ribera, José Luís Rosa, Juan Carlos García-Pagán, Jaime Bosch, Jarbas Rodrigues de Oliveira, Jordi Gracia-Sancho
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Hepatic stellate cells (HSC) play a key role in the development of chronic liver disease (CLD). Liraglutide, well-established in type 2 diabetes, showed anti-inflammatory and anti-oxidant properties. We evaluated the effects of liraglutide o
Externí odkaz:
https://doaj.org/article/900702cceaa04c7381a0e86421ce63a4
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 11 (2018)
Portal hypertension represents one of the major clinical consequences of chronic liver disease, having a deep impact on patients’ prognosis and survival. Its pathophysiology defines a pathological increase in the intrahepatic vascular resistance as
Externí odkaz:
https://doaj.org/article/6184159a51ff4e24bd9758cf2bea3c37
Autor:
Maria Guarino, Pavitra Kumar, Andrea Felser, Luigi M. Terracciano, Sergi Guixé-Muntet, Bostjan Humar, Michelangelo Foti, Jean-Marc Nuoffer, Marie V. St-Pierre, Jean-François Dufour
Publikováno v:
Cancers, Vol 12, Iss 6, p 1407 (2020)
Non-alcoholic fatty liver disease (NAFLD) leads to steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma. For sedentary patients, lifestyle interventions combining exercise and dietary changes are a cornerstone of treatment. However, the ben
Externí odkaz:
https://doaj.org/article/6fc0f7d4dd61411cb33f285ec42ff87c
Autor:
Sergi Guixé‐Muntet, Louise Biquard, Gyongyi Szabo, Jean‐François Dufour, Frank Tacke, Sven Francque, Pierre‐Emmanuel Rautou, Jordi Gracia‐Sancho
Publikováno v:
Alimentary pharmacology and therapeutics
Background Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors known to regulate glucose and fatty acid metabolism, inflammation, endothelial function and fibrosis. PPAR isoforms have been extensively studie