Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Sergi Castellano"'
Autor:
John R. Apps, Jose Mario Gonzalez-Meljem, Romain Guiho, Jessica C. Pickles, Eric Prince, Edward Schwalbe, Nikhil Joshi, Thomas J. Stone, Olumide Ogunbiyi, Jane Chalker, Akang Bassey, Georg Otto, Rosalind Davies, Debbie Hughes, Sebastian Brandner, Enrica Tan, Victoria Lee, Caroline Hayhurst, Cassie Kline, Sergi Castellano, Todd Hankinson, Timo Deutschbein, Thomas S. Jacques, Juan Pedro Martinez-Barbera
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract The two types of craniopharyngioma, adamantinomatous (ACP) and papillary (PCP), are clinically relevant tumours in children and adults. Although the biology of primary craniopharyngioma is starting to be unravelled, little is known about the
Externí odkaz:
https://doaj.org/article/0874ef81d5794b778ecf6f36f0dcbfe2
Autor:
Brais Bea-Mascato, Eduardo Gómez-Castañeda, Yara E. Sánchez-Corrales, Sergi Castellano, Diana Valverde
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-14 (2023)
Abstract Background Alström syndrome (ALMS) is a rare autosomal recessive disease that is associated with mutations in ALMS1 gene. The main clinical manifestations of ALMS are retinal dystrophy, obesity, type 2 diabetes mellitus, dilated cardiomyopa
Externí odkaz:
https://doaj.org/article/0f28d70848424b559a8a47c872a92d1d
Autor:
Vignesh Jayarajan, George T. Hall, Theodoros Xenakis, Neil Bulstrode, Dale Moulding, Sergi Castellano, Wei-Li Di
Publikováno v:
Cells, Vol 12, Iss 3, p 346 (2023)
Primary keratinocytes including keratinocyte stem cells (KSCs) can be cultured as epidermal sheets in vitro and are attractive for cell and gene therapies for genetic skin disorders. However, the initial slow growth of freshly isolated keratinocytes
Externí odkaz:
https://doaj.org/article/0305322fe49c4ab8a545bf67ed65af03
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Acute Myeloid Leukaemia (AML) is a phenotypically and genetically heterogenous blood cancer characterised by very poor prognosis, with disease relapse being the primary cause of treatment failure. AML heterogeneity arise from different genetic and no
Externí odkaz:
https://doaj.org/article/99f4e8c47ed04a738691e1948cb88a41
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008485 (2019)
Chimpanzees, humans' closest relatives, are in danger of extinction. Aside from direct human impacts such as hunting and habitat destruction, a key threat is transmissible disease. As humans continue to encroach upon their habitats, which shrink in s
Externí odkaz:
https://doaj.org/article/a0e752aa19c144d3998fbb7c92ec8a6f
Autor:
Meredyth G Ll Wilkinson, Dale Moulding, Thomas C R McDonnell, Michael Orford, Chris Wincup, Joanna Y J Ting, Georg W Otto, Restuadi Restuadi, Daniel Kelberman, Charalampia Papadopoulou, Sergi Castellano, Simon Eaton, Claire T Deakin, Elizabeth C Rosser, Lucy R Wedderburn
Publikováno v:
Annals of the Rheumatic Diseases. 82:658-669
ObjectivesTo define the host mechanisms contributing to the pathological interferon (IFN) type 1 signature in Juvenile dermatomyositis (JDM).MethodsRNA-sequencing was performed on CD4+, CD8+, CD14+and CD19+cells sorted from pretreatment and on-treatm
Autor:
George T. Hall, Sergi Castellano
Analysis of single-cell transcriptomes can identify cell populations more abundant in one sample or condition than another. However, existing methods to discover them suffer from either low discovery rates or high rates of false positives. We introdu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2830b72b11c062e59ac2e5a214ade2b9
https://doi.org/10.1101/2023.05.05.539427
https://doi.org/10.1101/2023.05.05.539427
Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase
Autor:
Jasmin Rees, Gaurab Sarangi, Qing Cheng, Martin Floor, Aida M Andrés, Baldomero Oliva Miguel, Jordi Villà-Freixa, Elias SJ Arnér, Sergi Castellano
Selenocysteine (Sec), the 21stamino acid specified by the genetic code, is a rare selenium-containing residue found in the catalytic site of selenoprotein oxidoreductases. Sec is analogous to the common cysteine (Cys) amino acid but its selenium atom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f2b8f0d9be65837ae98a2fa7dc2f31d
https://doi.org/10.1101/2023.01.03.522577
https://doi.org/10.1101/2023.01.03.522577
Autor:
Ilaria M. Michelozzi, Eduardo Gomez-Castaneda, Ruben V. C. Pohle, Ferran Cardoso Rodriguez, Jahangir Sufi, Pau Puigdevall Costa, Meera Subramaniyam, Efstratios Kirtsios, Ayad Eddaoudi, Si Wei Wu, Aleks Guvenel, Jonathan Fisher, Sara Ghorashian, Martin A. Pule, Christopher J. Tape, Sergi Castellano, Persis J. Amrolia, Alice Giustacchini
Publikováno v:
Blood advances.
We recently described a low-affinity second-generation CD19 chimeric antigen receptor (CAR) CAT that showed enhanced expansion, cytotoxicity, and antitumor efficacy compared with the high-affinity (FMC63-based) CAR used in tisagenlecleucel, in precli
Autor:
Brais Bea-Mascato, Eduardo Gómez-Castañeda, Yara E. Sánchez-Corrales, Sergi Castellano, Diana Valverde
BackgroundAlström syndrome (ALMS) is a rare autosomal recessive disease that is associated with mutations inALMS1gene. The main clinical manifestations of ALMS are retinal dystrophy, obesity, type 2 diabetes mellitus, dilated cardiomyopathy and mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b31b72aa70295fafe466b8b54fcc1f1a
https://doi.org/10.1101/2022.11.02.514847
https://doi.org/10.1101/2022.11.02.514847