Zobrazeno 1 - 10
of 339
pro vyhledávání: '"Sergi, Ferré"'
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 5, Pp 1409-1410 (2025)
Externí odkaz:
https://doaj.org/article/9a853a48a89a4290a4da55add065598e
Autor:
Marta Valle-León, Nil Casajuana-Martin, Claudia Llinas del Torrent, Josep Argerich, Laura Gómez-Acero, Kristoffer Sahlholm, Sergi Ferré, Leonardo Pardo, Francisco Ciruela
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 160, Iss , Pp 114327- (2023)
The striatal dopamine D2 receptor (D2R) is generally accepted to be involved in positive symptoms of schizophrenia and is a main target for clinically used antipsychotics. D2R are highly expressed in the striatum, where they form heteromers with the
Externí odkaz:
https://doaj.org/article/719ba51101504107881ca2cf73a00e28
Autor:
Laura I. Sarasola, Claudia Llinas del Torrent, Andrea Pérez-Arévalo, Josep Argerich, Nil Casajuana-Martín, Andy Chevigné, Víctor Fernández-Dueñas, Sergi Ferré, Leonardo Pardo, Francisco Ciruela
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113896- (2022)
Adenosine modulates neurotransmission through inhibitory adenosine A1 receptors (A1Rs) and stimulatory A2A receptors (A2ARs). These G protein-coupled receptors are involved in motor function and related to neurodegenerative diseases such as Parkinson
Externí odkaz:
https://doaj.org/article/3f7bb7c54d1648fc8f8283f76a91ab64
Autor:
Sergi Ferré, Annabelle M. Belcher, Jordi Bonaventura, César Quiroz, Marta Sánchez-Soto, Verònica Casadó-Anguera, Ning-Sheng Cai, Estefanía Moreno, Comfort A. Boateng, Thomas M. Keck, Benjamín Florán, Christopher J. Earley, Francisco Ciruela, Vicent Casadó, Marcelo Rubinstein, Nora D. Volkow
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The functional and pharmacological significance of the dopamine D4 receptor (D4R) has remained the least well understood of all the dopamine receptor subtypes. Even more enigmatic has been the role of the very prevalent human DRD4 gene polymorphisms
Externí odkaz:
https://doaj.org/article/296e48e160894ee886f69c1f180469c2
Autor:
Aaro V. Salminen, Stefan Clemens, Diego García-Borreguero, Imad Ghorayeb, Yuqing Li, Mauro Manconi, William Ondo, David Rye, Jerome M. Siegel, Alessandro Silvani, John W. Winkelman, Richard P. Allen, Sergi Ferré, the International Restless Legs Syndrome Study Group (IRLSSG)
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 8 (2022)
Our understanding of the causes and natural course of restless legs syndrome (RLS) is incomplete. The lack of objective diagnostic biomarkers remains a challenge for clinical research and for the development of valid animal models. As a task force of
Externí odkaz:
https://doaj.org/article/023de1a8a3c04fb99ab94efdb914cf93
Autor:
Attila Köfalvi, Estefanía Moreno, Arnau Cordomí, Ning-Sheng Cai, Victor Fernández-Dueñas, Samira G. Ferreira, Ramón Guixà-González, Marta Sánchez-Soto, Hideaki Yano, Verònica Casadó-Anguera, Rodrigo A. Cunha, Ana Maria Sebastião, Francisco Ciruela, Leonardo Pardo, Vicent Casadó, Sergi Ferré
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-21 (2020)
Abstract Background It has been hypothesized that heteromers of adenosine A2A receptors (A2AR) and cannabinoid CB1 receptors (CB1R) localized in glutamatergic nerve terminals mediate the integration of adenosine and endocannabinoid signaling involved
Externí odkaz:
https://doaj.org/article/7b04e035274446de8e3bed6703c6c493
Autor:
David Moreno-Delgado, Mar Puigdellívol, Estefanía Moreno, Mar Rodríguez-Ruiz, Joaquín Botta, Paola Gasperini, Anna Chiarlone, Lesley A Howell, Marco Scarselli, Vicent Casadó, Antoni Cortés, Sergi Ferré, Manuel Guzmán, Carmen Lluís, Jordi Alberch, Enric I Canela, Silvia Ginés, Peter J McCormick
Publikováno v:
eLife, Vol 9 (2020)
Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D1R over-activation, we present a strategy based on targeting complexes of D1
Externí odkaz:
https://doaj.org/article/e29f5e9398d54a2882b616c452b949ae
Autor:
Matilde S. Rodrigues, Samira G. Ferreira, César Quiroz, Christopher J. Earley, Diego García-Borreguero, Rodrigo A. Cunha, Francisco Ciruela, Attila Köfalvi, Sergi Ferré
Publikováno v:
Molecules, Vol 27, Iss 5, p 1489 (2022)
Brain iron deficiency (BID) constitutes a primary pathophysiological mechanism in restless legs syndrome (RLS). BID in rodents has been widely used as an animal model of RLS, since it recapitulates key neurochemical changes reported in RLS patients a
Externí odkaz:
https://doaj.org/article/84996bcbe2df4dbba35686e4de4c23b3
Publikováno v:
BioTechniques, Vol 65, Iss 1, Pp 9-14 (2018)
Protein complementation assays (PCA) are used as pharmacological tools, enabling a wide array of applications, ranging from studies of protein–protein interactions to second messenger effects. Methods to detect activities of G protein-coupled recep
Externí odkaz:
https://doaj.org/article/99b352e874484e2592c0a5f9724a88c4
Autor:
Gemma Navarro, Arnau Cordomí, Verónica Casadó-Anguera, Estefanía Moreno, Ning-Sheng Cai, Antoni Cortés, Enric I. Canela, Carmen W. Dessauer, Vicent Casadó, Leonardo Pardo, Carme Lluís, Sergi Ferré
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form
Externí odkaz:
https://doaj.org/article/ddb2e76a96254f8299931ae5586deefc